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Pixelated-polarization-camera-based polarimetry system for wide real-time optical rotation measurement
摘要： Chirality is an essential consideration in the field of life sciences and pharmaceutical industry because most biomolecules and pharmaceuticals are chiral, and optical rotation measurement is a simple and efficient means for identification, purity test and content detection of chiral materials. However, there are some drawbacks in existing methods, such as small measurement range, non-real-time performance, low measurement accuracy and resolution. This paper presents a novel system to implement optical rotation measurement, and pixelated polarization cameras and Stokes parameters are employed in the system. The polarization information of linearly polarized incident light can be recorded and extracted by a pixelated polarization camera and Stokes parameters respectively. Experiments demonstrate that the proposed system has the necessary advantages for optical rotation measurement, such as real time, wide range ( ?90 ° ～ +90 °), high accuracy ( ±4 ×10?6 °) and high resolution ( 6 ×10?11 °). Thus, this measurement system has great practical prospects in the hospital clinical diagnosis, chemical research, sugar production and pharmaceutical industry.
关键词： pixelated micropolarizer array,optical rotation,chiral drug,polarimetry,Stokes parameters
更新于2025-11-25 10:30:42
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Absolute Configuration Assignment from Optical Rotation Data by Means of Biphenyl Chiroptical Probes
摘要： A novel non-empirical approach for the assignment of absolute configuration of chiral 2-alkyl substituted carboxylic acids and primary amines by [a]D measurements has been developed. The method requires the conversion of the chiral acids or amines into the corresponding 4,4'-disubstituted biphenylamides or biphenylazepines, respectively. In these derivatives a central-to-axial chirality transfer induces a preferred torsion in the biphenyl moiety revealed by the sign of the biphenyl A band in the ECD spectrum. By 4,4'-substitution on the biphenyl moiety a redshift of the A band is obtained, leading to an increase of its relative contribution to optical rotation. This allows to reliably establish a direct correlation between the [a]D sign, the biphenyl twist and, then, the substrate absolute configuration. This approach thus constitutes a really practical and reliable method to assign the absolute configuration of chiral carboxylic acids and primary amines by simple and straightforward [a]D measurement, readily obtainable by a routine instrumentation like the polarimeter.
关键词： optical rotation,circular dichroism,biphenyls,absolute configuration,chiroptical probes
更新于2025-09-19 17:15:36
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Conformer Pair Contributions to Optical Rotations in a Series of Chiral Linear Aliphatic Alcohols
摘要： The chain length effect of four chiral aliphatic alcohols, (S)-2-butanol, (S)-2-pentanol, (S)-2-hexanol and (S)-2-heptanol, on their specific optical rotations(OR) was studied experimentally and theoretically via quantum theory. Many conformations of each chiral alcohol exist as conformer pairs in solution. The OR sum from these pairs of conformers has much smaller contributions to OR values than that contributed by the most stable conformation. These four alcohols’ OR values were also investigated using the matrix model, which employs each substituent’s comprehensive mass, radii, electronegativity and symmetry number as the elements in the matrix. These are all particle properties. This matrix determinant is proportional to its OR values within a closely related structural series of chiral compounds. The experimental OR values and the matrix determinants of these four alcohols were compared with the predicted OR values obtained from quantum theory wave functions. The ORs predicted by the matrix method, which is based on particle function statistics, agreed with the results from quantum theory. The agreement between OR predictions by the matrix method and DFT calculations illustrates the wave-particle duality of polarized light that is operating in these predictions.
关键词： Absolute configuration,Optical rotation,Quantum computation,Matrix model,Conformer pair
更新于2025-09-09 09:28:46
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Breaking the Energy-Symmetry-Based Propagation Growth Blockade in Magneto-Optical Rotation
摘要： The magneto-optical polarization rotation effect has myriad applications in many research areas spanning the scientific spectrum, including space and interstellar research, nanotechnology, material science, biomedical imaging, and subatomic particle research. In the nonlinear magneto-optical rotation (NMOR) effect, the angle of rotation of a linearly polarized optical field in a magnetized medium is dependent upon its intensity. However, typical NMOR signals of conventional single-beam Λ-scheme atomic magnetometers are peculiarly small, requiring sophisticated magnetic shielding and high-frequency phase-sensitive detection. Here, we show the presence of an energy-symmetry-based propagation growth blockade that undermines the NMOR effect in conventional single-beam Λ-scheme atomic magnetometers. We further demonstrate, both experimentally and theoretically, an inelastic wave-mixing technique that breaks this NMOR blockade, resulting in more-than-2-orders-of-magnitude enhancement of the NMOR signal power amplitude that cannot be achieved with conventional single-beam Λ-scheme atomic magnetometers. This technique, demonstrated here with substantially reduced light intensities at near-room temperatures, may lead to many applications, especially in the field of biomagnetism and high-resolution low-field magnetic imaging.
关键词： atomic magnetometers,wave-mixing,magneto-optical rotation,biomagnetism,nonlinear magneto-optical rotation,magnetic imaging
更新于2025-09-04 15:30:14