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Digital Pulse Oximetry for the Screeing of Lower Extremity Arterial Disease
摘要： The aim of the study was to investigate the usefulness of a handheld digital pulse oximetry in the detection of lower extremity arterial disease. A Retrospective study was performed in 45 patients with lower extremity arterial disease. We compared the accuracy of a handheld digital pulse oximetry and the ankle brachial index (ABI). Digital pulse oximetry was conducted for 42 patients with 84 limbs to measure the SaO2 of their index fingers and big toes in supine position. The ABI was defined as abnormal if it was less than 0.9. Pulse oximetry of big toes was defined as abnormal if the SPO2 was less than 96% or it was more than 2% lower than that of the index finger. Digital pulse oximetry had a sensitivity of 47%(95% CI, 34-60%) and specificity of 86%(95% CI, 64-96%). ABI had a sensitivity of 49%(95% CI, 34-64%) and specificity of 95%(95% CI, 72-99%). Positive predictive values were 91%(95% CI, 74-98%) for digital pulse oximetry and 96%(95% CI, 77-99%) for ABI. Negative predictive values were 37%(95% CI, 24-51%) for digitial pulse oximetry and 43%(95% CI, 25-72%) for ABI. In 22 cases with acute ischemicwere the sensitivity 73%, the specifity 100%, the positive predictive value 100% and the negative predictive value 79%. Handheld digital pulse oximetry of the big toes seems as accurate as ABI to detect lower extremity arterial diseases. The combination of both will help to distinguish low extremity arterial disease and spinal radiculopathy.
关键词： pulse oximetry,ankle brachial index,arterial disease
更新于2025-09-04 15:30:14
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Reliability and Determinants of Retinal Vessel Oximetry Measurements in Healthy Eyes
摘要： PURPOSE. To assess the reliability and determinants of retinal vessel oximetry measurements with the Oxymap T1 Retinal Oximeter in normal Asian eyes. METHODS. Subjects older than 40 years without a history of stroke and heart disease were recruited from a community-based clinic. Subjects underwent standardized systemic and ocular examinations. Normal eyes were de?ned as eyes without major eye diseases such as age-related macular degeneration, glaucoma, or retinopathy. Retinal vessel oximetry levels were measured by using the Oxymap T1 Retinal Oximeter. Intra- and intergrader reliability of retinal vessel oximetry measurements were assessed by using 50 images. Intravisit repeatability of retinal vessel oximetry measurements was assessed by using 20 paired images. Univariable linear regression was performed to examine the associations between retinal vessel oximetry measurements and systemic determinants. RESULTS. A total of 118 retinal oximetry images were included in the ?nal analysis. Intra- (intraclass correlation coef?cient [ICC] values: 0.89–0.99) and intergrader (ICC values: 0.77–0.94) reliability, and intravisit (ICC values: 0.85–0.96) repeatability were both high. In the linear regression analysis, older age was associated with reduced overall retinal venular oximetry levels (b: (cid:2)2.61%; 95% con?dence interval [CI]: (cid:2)4.92 to (cid:2)0.29) and reduced inferior–nasal retinal venular oximetry levels (b: (cid:2)3.53%; 95% CI: (cid:2)6.07 to (cid:2)0.99). CONCLUSIONS. The Oxymap Retinal Oximeter allows reliable and repeatable retinal vessel oximetry measurements. Age is the main factor that in?uences retinal venular oximetry levels and should be taken into account when retinal oximetry measurements are interpreted.
关键词： retinal oximetry,functional imaging,retinal oxygen saturation
更新于2025-09-04 15:30:14
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Changes in cerebral oxygenation and cerebral blood flow during hemodialysis – A simultaneous near-infrared spectroscopy and positron emission tomography study
摘要： Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO2) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [15O]H2O positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO2 and CBF. In 12 patients aged (cid:2) 65 years, NIRS and PET were performed simultaneously: before (T1), early after start (T2), and at the end of hemodialysis (T3). Between T1 and T3, the relative change in frontal rSO2 (DrSO2) was (cid:3)8 (cid:4) 9% (P ? 0.001) and (cid:3)5 (cid:4) 11% (P ? 0.08), whereas the relative change in frontal gray matter CBF (DCBF) was (cid:3)11 (cid:4) 18% (P ? 0.009) and (cid:3)12 (cid:4) 16% (P ? 0.007) for the left and right hemisphere, respectively. DrSO2 and DCBF were weakly correlated for the left (r 0.31, P ? 0.4), and moderately correlated for the right (r 0.69, P ? 0.03) hemisphere. The Bland-Altman plot suggested underestimation of DCBF by NIRS. Divergent associations of pH, pCO2 and arterial oxygen content with rSO2 were found compared to corres- ponding associations with CBF. In conclusion, NIRS could be a proxy to PET to detect intradialytic CBF changes, although NIRS and PET capture different physiological parameters of the brain.
关键词： cerebral oximetry,hemodialysis,water-PET,Brain perfusion,NIRS
更新于2025-09-04 15:30:14