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Spectroscopy of Oxygen-Sensitive Material for Measuring Contact Lens Oxygen Transmissibility
摘要： Purpose: Oxygen permeability or transmissibility is a crucial parameter for contact lenses to ensure that extended wear will not induce corneal hypoxia. This work tests a new method of using the oxidation of cysteamine, an oxygen-sensitive chemical, to quantify the oxygen transmissibility of current commercial contact lenses and contact lenses loaded with vitamin E. Methods: 3D printing was used to modify eye drop bottles and quartz cuvettes to create systems that allowed insertion of a contact lens in between the cysteamine solution and air. Both systems were exposed to atmospheric conditions where the only path of entry for oxygen was through the contact lens. The entering oxygen reacted with cysteamine, and the rate of cysteamine oxidation was measured using UV-vis spectrophotometry. The rate was then stoichiometrically related to oxygen transmissibility. Results: The eye drop method predicted transmissibility values within 9% of established, commercial values. The cuvette method predicted values within 10% of established values for silicone hydrogel lenses without any correction factor and within 11% for poly-hydroxyethyl-methacrylate lenses after correcting for oxygen entering the system. Incorporation of 20% (w/w) vitamin E into Acuvue? Oasys? lenses did not have a significant impact on the oxygen transmissibility. Conclusions: Both methods presented in this work can reliably measure oxygen transmissibility of contacts lenses or other materials. Further improvements in manufacturing could lead to improved accuracy and reliability, allowing wider use of this method for quantifying the oxygen transport in contact lenses.
关键词： oxidation,oxygen permeability,spectrophotometry,3D printing,contact lens
更新于2025-09-23 15:23:52
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Contact Lenses || Contact Lens Materials
摘要： The chapter provides an overview of contact lens materials, focusing on their development, properties, and the ocular response they elicit. It discusses the evolution from glass and PMMA to silicone hydrogels, highlighting the importance of oxygen permeability, wettability, and mechanical properties in lens design. The chapter also explores the challenges in achieving biocompatibility and comfort, the impact of lens materials on ocular health, and the future directions in materials development to address issues like dry eye and the ageing ocular surface.
关键词： Oxygen Permeability,Dry Eye,Ocular Response,Ageing Anterior Eye,Silicone Hydrogels,Contact Lens Materials,Biocompatibility
更新于2025-09-04 15:30:14