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Endowing Light-Inert Aqueous Surfactant Two-Phase System with Photo Responsiveness by Introducing a Trojan Horse
摘要： The ability to modulate the phase behavior of aqueous surfactant two-phase (ASTP) system reversibly with light is of great importance in both fundamental and applied science. Thus far, most of the light-responsive ASTP systems are based on covalent-modification of the component molecules. In this article, we for the first time achieve photo-responsiveness in a light-inert ASTP system by physically introducing a photo-trigger with the aid of an Trojan Horse. The ATPS system formed with sodium laurate (SL) and dodecyl tributyl amomium (DBAB) doesn’t show light responsiveness by physically mixing a light responsive azobenzene compound, 2-(4-(phenyldiazenyl)phenoxy)actate sodium (Azo). However, in the presence of the host-guest complex SL@β-CD formed with β-CD and sodium laurate (SL), the ASTP turns quickly into a homogenous suspension under visible light, which recovers to the original ASTP state again under 365 nm UV irradiation. Because the SL@β-CD complex exists harmonically with the ASTP, it can be viewed as a “Trojan horse” that becomes fatal only when the encapsulated SL is triggered to release. In the presence of the Trojan horse, the photo-responsiveness of the ASTP can be manipulated reversibly by alternatively exerting UV and visible light. Using this strategy, we are able to collect trace amount of oily components from water. The current strategy points out that it is possible to achieve light-responsiveness in light-inert systems with physical method, which may have profound impact both on the fundamental and applied science.
关键词： Cyclodextrin,Azobenzene,Trojan horse,Host-Guest Interaction,Aqueous surfactant two-phase system,Photo-Responsive
更新于2025-11-25 10:30:42
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A novel near-infrared light responsive 4D printed nanoarchitecture with dynamically and remotely controllable transformation
摘要： Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed, self-assembly structures with the ability to transform over time. However, one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart, dynamic capabilities to spatiotemporally and instantly control the shape-transformation process. Here, we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer, allowing the 4D printed object to achieve a dynamic and remote controlled, on-time and position shape transformation. A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation, and the feasibility of photothermal stimulation for modulating neural stem cell behaviors. This novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR), but can also provide a potential method for building complex self-morphing objects for widespread applications.
关键词： brain,4D printing,dynamically and remotely controllable,neural stem cell,near-infrared light responsive,graphene
更新于2025-11-21 11:08:12
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Highly Sensitive and Selective Fluorescent Sensor based on a Multi-Responsive Ultrastable Amino-Functionalized Zn(II)-MOF for Hazardous Chemicals
摘要： A microscale amino-functionalized Zn(II)-MOF, namely [Zn(NH2-bdc)(4,4’-bpy)] (1) (NH2-H2bdc = 2-amino-1,4-benzenedicarboxylic acid and 4,4’-bpy = 4,4’-bipyridine), has been successfully synthesized, structurally characterized and further utilized as multi-responsive fluorescent sensor for highly sensitive and selective detection of Cr(VI) and 2,4,6-trinitrophenol (TNP). Compound 1 features non-porous 5-fold interpenetrated 3D framework with the Lewis basic sites including the uncoordinated amino and carboxylate groups on the framework for anchoring and recognizing the guest. 1 exhibits not only excellent water and thermal stability but also tolerance to acidic and basic media over an extensive pH range of 2-12. This ultrastable material can sensitively and selectively detect Cr2O7 2- and CrO4 2- in water based on the luminescent quenching with relatively low limits of detection (2.21 μM for CrO4 2- and 1.30 μM for Cr2O7 2-). Moreover, the unprecedented solvent-dependent luminescent response of 1 as a fluorescent probe for high-efficiency TNP detection was observed. Significantly, 1 not only displays high sensitive fluorescent enhancement upon TNP binding in ethanol but also exhibits fluorescent quenching toward TNP in water with very low limits of detection of 4.47 nM and 0.32 μM in ethanol and water, respectively. This work reports the first example of the utilization of MOF as a sensor for the detection of TNP based on dual responsive luminescence. Importantly, 1 can be simply and rapidly regenerated, displaying excellent recyclability after the sensing experiments.
关键词： Multi-responsive fluorescent sensors,Fluorescent quenching,Metal-organic framework,2,4,6-trinitrophenol,Fluorescent enhancement,Cr(VI)
更新于2025-11-19 16:46:39
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Perfluorocarbon-Loaded and Redox-Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy
摘要： The wide clinical application of photodynamic therapy (PDT) is hampered by poor water solubility, low tumor selectivity, and nonspecific activation of photosensitizers, as well as tumor hypoxia which is common for most solid tumors. To overcome these limitations, tumor-targeting, redox-activatable, and oxygen self-enriched theranostic nanoparticles are developed by synthesizing chlorin e6 (Ce6) conjugated hyaluronic acid (HA) with reducible disulfide bonds (HSC) and encapsulating perfluorohexane (PFH) within the nanoparticles (PFH@HSC). The fluorescence and phototoxicity of PFH@HSC nanoparticles are greatly inhibited by a self-quenching effect in an aqueous environment. However, after accumulating in tumors through passive and active tumor-targeting, PFH@HSC appear to be activated from “OFF” to “ON” in photoactivity by the redox-responsive destruction of the vehicle’s structure. In addition, PFH@HSC can load oxygen within lungs during blood circulation, and the oxygen dissolved in PFH is slowly released and diffuses over the entire tumor, finally resulting in remarkable tumor hypoxia relief and enhancement of PDT efficacy by generating more singlet oxygen. Taking advantage of the excellent imaging performance of Ce6, the tumor accumulation of PFH@HSC can be monitored by fluorescent and photoacoustic imaging after intravenous administration into tumor-bearing mice. This PFH@HSC nanoparticle might have good potential for dual imaging-guided PDT in hypoxic solid tumor treatment.
关键词： tumor hypoxia,hyaluronic acid nanoparticles,perfluorocarbon,redox-responsive,photodynamic therapy
更新于2025-11-19 16:46:39
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Photo-Controlled Release of Metal Ions Using Triazoline-Containing Amphiphilic Copolymers
摘要： Photo-controlled release that shows quick response and high spatial/temporal accuracy has become attractive given its potential applications for biomedicines. A few metal complexes are known for detoxification, sterilization, diagnosis and treatment of diseases; but, the encapsulation and control release of those metal ions using polymer micelles are challenging. We report an interesting photo-controlled release of metal ions via photo-responsible triazoline-containing amphiphilic polymers. Amphiphilic random copolymers of glycidyl methacrylate and oligo(ethylene oxide) methyl ether methacrylate were prepared through free radical copolymerization. The glycidyl pendants were converted to azide, followed by a 1,3-dipolar cycloaddition reaction to form triazoline with norbornene. The resulting random copolymers containing triazoline formed micelles with a critical micellar concentration (CMC) of 7.68×10-3 mg/mL. The triazoline moieties could coordinate to transition metal ions, e.g. Co2+, thus to encapsulate the metal ions to the core of micelles. Photo-induced denitrogenation of triazoline was able to disrupt the coordination of Co2+ and triazoline, therefore leading to the release of Co2+. Solution viscosity, UV-vis/NMR spectroscopy and TEM were used to show that the coordination and release of Co2+ ions were successful upon exposure to light. The photo-controlled release profile was found to be linearly dependent on the irradiation time, which is potentially useful for the delivery of essential ions in vivo.
关键词： Light responsive,Amphiphilic polymers,Micelles,Triazoline,Photo-controlled release
更新于2025-11-19 16:46:39
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A pH-responsive zinc (II) metalated porphyrin for enhanced photodynamic/photothermal combined cancer therapy; 一种用于增强光动力/光热协同肿瘤治疗的酸性 刺激响应锌(II)金属卟啉化合物;
摘要： The acidic tumor microenvironment is triggered by glycolysis in hypoxic condition, which can motivate the pH-responsive system to build certain triggers for efficiently tumor-targeted phototherapy. Additionally, the metalated porphyrin structures are widely studied in biomedical applications due to the favorable properties of high singlet oxygen quantum yield as well as strong fluorescence imaging ability. Herein, a pH-responsive zinc (II) metalated porphyrin (P-4) was designed and synthesized for amplifying cancer photodynamic/photothermal therapy with excellent fluorescence quantum yield (67.4%), superb singlet oxygen quantum yield (84.3%) and desired photothermal conversion efficiency (30.0%). In vitro, the self-assembled P-4 nanoparticles can specifically target to lysosome subcellular site and realize protonated process of dibutaneaminophenyl (DBAP) groups with high photo toxicity. Under single 660 nm laser illumination, the tumor can be ablated completely with no side effects in vivo. This work demonstrates that the pH-responsive P-4 nanoparticles provide a new avenue for highly efficient cancer combination therapy.
关键词： porphyrin,pH-responsive,NIR absorbance,photothermal therapy,photodynamic therapy
更新于2025-11-14 15:29:11
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Green Synthesis of Carrier-Free Curcumin Nanodrugs for Light-activated Breast Cancer Photodynamic Therapy
摘要： Photodynamic therapy (PDT) is a promising procedure for breast cancer therapy. Curcumin (Cur), a hydrophobic polyphenol derived from the spice turmeric, has been considered as a potential photosensitizer for PDT with evoked immune response, excellent safety, and low cost. However, the translation of curcumin in clinical cancer therapy suffers from an insufficient therapeutic dose in tumor tissues due to its poor solubility and low bioavailability. In this study, carrier-free curcumin nanodrugs (Cur NDs) were prepared without using any toxic solvents through a facile and green reprecipitation method. Cur NDs exhibited distinct optical properties, light-sensitive drug release behavior, resulting in increased reactive oxygen species (ROS) generation and PDT efficacy on breast cancer cells compared with free Cur. Furthermore, cell apoptosis during Cur-based PDT was concomitant with the activation of the ROS-mediated JNK/caspase-3 signaling pathway. Overall, our carrier-free Cur nanodrugs may be promising candidates for facilitating the efficacy and safety of PDT against breast cancer.
关键词： Carrier-free,Curcumin,Light-responsive drug release,Breast cancer,Photodynamic therapy
更新于2025-11-14 15:26:12
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Ammonia-Responsive Luminescence of Ln3+-β-diketonate Complex Encapsulated within Zeolite Y
摘要： Assembling Ln3+(HPBAn) (Ln = Eu or Tb, HPBA = N-(2-pyridinyl)benzoylacetamide) in the cavities of zeolite Y (ZY) via the “ship-in-a-bottle” strategy leads to the formation of novel luminescent composite, Ln(HPBAn)@ZY, whose luminescence can be easily modulated by ammonia on the basis of the energy level variation of HPBA after deprotonation process. Additionally the bimetallic complex doping sample, Eu0.5Tb0.5(HPBAn)@ZY, show great potential as self-referencing luminescent sensor for detecting low ammonia concentration of 10?12–0.25 wt%.
关键词： zeolite Y,luminescence,Ln3+-β-diketonate complex,ammonia-responsive
更新于2025-11-14 15:18:02
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Multi-stimuli Responsive Supramolecular Gels Based on a D-π-A Structural Cyanostilbene Derivative with Aggregation Induced Emission Properties
摘要： Developing multi-stimuli responsive fluorescent gel materials in a single system remains challenging. Gelator molecules with classical fluorophores suffer from aggregation-caused quenching (ACQ) effect, limiting their applications further. Herein, a novel V-shaped cyanostilbene-based molecule (BAPBIA) with aggregation induced emission (AIE) characteristics and great gelation ability was synthesized and was found to exhibit multi-stimuli responsive behaviors. Reversible gel-sol phase transitions together with emission quenching are realized in response to external stimuli including heating, light and fluoride ion. Especially, the introduction of dimethylaniline group (donor) and cyano group (acceptor) generates a D-π-A structure, further leading to an intramolecular charge transfer (ICT) effect, which enlarges the emission contrast with the variations of the distribution of charge. Thus, upon trifluoroacetic acid (TFA) triggered protonation of dimethylaniline group, not only gel-sol transition but also emission color switching (yellow-to-blue) is achieved due to the loss of the ICT effect. This work paves an easy way to construct fully reversible multi-stimuli responsive fluorescence modulation smart materials.
关键词： supramolecular gels,aggregation induced emission,multi-stimuli responsive,fluorescence switching,cyanostilbene derivative
更新于2025-11-14 15:14:40
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Scaling effects on the optical properties of patterned nano-layered shape memory films
摘要： Nano-layered films of PVAc/PU systems were fabricated by forced assembly coextrusion method. The bulk shape memory properties of PVAc/PU systems were utilized to program nanoscale patterns such as diffraction grating which exhibit iridescence after patterning. A hot embossing process has been utilized to imprint diffraction grating patterns as nano-scale information onto the surface of the thin multilayer films. Three levels of hierarchy i.e. layer thickness, spacing and heights of patterns, governs the functionality of the patterned multilayer film. The time and temperature dependent viscoelastic shape memory behavior determines the opto-mechanical tunability of the film. Mechanical switching of the patterns also leads to optical switching of the films which corresponds to their efficiency of information retrieval. The recovery of patterns as well as the diffractive property depends on the layer thickness (l) of films and heights of patterns (h0). The results illustrate that the higher ratio of h0/l better is the recovery of the grating patterns and the corresponding diffractive properties. This scaling effect enables versatile applications in information security by tuning the layer structure of the multilayer shape memory films.
关键词： scaling effect,shape memory film,pattern programming,hot embossing,multilayer film,information security,diffractive optical element,thermal responsive optics
更新于2025-10-22 19:40:53