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Azobenzene-based small molecular photoswitches for protein modulation
摘要： Molecular photoswitches are a class of chemical structures that can readily isomerize between distinct geometries upon irradiation with light. Molecular photoswitches are utilized to control protein structure and function with temporal and spatial precision. In this review, we summarize the recent progress in the development of azobenzene-based molecular photoswitches and their applications in the photocontrol of protein structure and function. For clarity of discussion, we divide the known photoswitchable proteins into different categories: protein motifs, ion channels, receptors, and enzymes. Basic approaches and considerations for the structure-guided design of photoswitchable ligands are discussed. The applications and limitations of current photoswitches are also discussed.
关键词： protein modulation,molecular design,azobenzene,photocontrol,photoswitches
更新于2025-09-19 17:15:36
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Substituent Effect on Metastable‐State Photoacids: Design, Synthesis and Evaluation of their Photochemical Properties
摘要： Recently, metastable-state photoacids have been widely used to control proton transfer in numerous chemical and biological processes as well as applications with visible light. Generally, substituent groups have great influence on photochemical properties of molecules, which will further affect their applications. Yet, substituent effect on the metastable-state photoacid has not been studied systematically. In this work, sixteen metastable-state photoacid derivatives were designed and synthesized based on their substituents involving a large range of σ-π electron-donor-acceptor capability. Substituent effects main on their color display (or maximum absorption peak(s)), solubility, pKa(s), dark-/photo-acidity, photosensitivity and relaxation kinetic(s) were investigated in detail. This study will be conducive to targetedly design and synthesize promising photoacids as well as to apply their photo-controlled proton-release processes in functional materials/devices.
关键词： visible-light-response,metastable-state photoacid,pH photocontrol,substituent effect,chemical dynamics
更新于2025-09-09 09:28:46