[IEEE 2018 IEEE International Ultrasonics Symposium (IUS) - Kobe, Japan (2018.10.22-2018.10.25)] 2018 IEEE International Ultrasonics Symposium (IUS) - Simulation of Photoacoustic Imaging of Red Blood Cell Aggregation Using a Numerical Model of Pulsatile Blood Flow

摘要： Photocatalytic imaging of blood flow using a pulsed laser diode of semiconductor blood flow aggregation and oxygenation saturation (sO2) estimation. During blood flow aggregation, the oxygen saturation of the blood flow is affected by the interaction between red blood cell (RBC) aggregation and the oxygen saturation (sO2) [1-7]. The mechanism of the aggregation is not yet fully understood. To date, two models, namely the bridging and depletion models, are proposed for explaining the kinetics of RBC aggregation [20-21]. Using the proposed models, new efforts have been published to investigate the kinetics of RBC aggregation [22-24]. In this paper, a simple particle motion model in two-dimensional (2D) space was introduced to understand the photothermal imaging of blood flow aggregation from the flow model. The flow model consisted of 125 elements spaced at 10 μm center-to-center, yielding a lateral length of 22.0 mm. The incident laser fluence was less than 10 mJ/cm2, below the safety limit by the American National Standards Institute (ANSI) for these wavelengths. The photothermal power (PTP) was computed from the flow model at each time step, and the simulated PTP was compared to the measured PTP in vivo. From the comparison, the kinetics of RBC aggregation was studied.