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oe1(光电查) - 科学论文

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?? 中文（中国） ▾

  • Efficacy of microneedling versus fractional Er:YAG laser in facial rejuvenation

    摘要： Background: Microneedling and fractional lasers have been used in facial rejuvenation with acceptable results and low adverse effects. Aims: To compare the efficacy of microneedling with fractional Er:YAG in facial skin rejuvenation. Patients/Methods: This study was planned as a split-face clinical trial. Volunteers were randomly allocated to receive three monthly treatments on each side of the face, one with fractional Er:YAG laser and one with microneedling. The assessments included investigating clinical outcomes by two blinded dermatologists accompanied by measuring skin biophysical characteristics including cutaneous resonance running time (CRRT) and transepidermal water loss (TEWL). Moreover, possible adverse effects, downtime, and patients' satisfaction were recorded at baseline, 1 month after each treatment, and 3 months after the last treatment session. The protocol was approved by the Iranian Registry of Clinical Trials (IRCT20160820029436N3). Results: Of the 32 selected volunteers, 24 subjects completed the study. The clinical assessment showed a significant improvement of the face appearance along with a significant reduction in dyschromia, and periorbital wrinkling (P-value < .05), with both procedures without any considerable difference between two methods. Moreover, the patients showed substantial satisfaction with both modalities with no statistically significant difference. Mean TEWL and CRRT values also decreased significantly in both groups with no considerable difference. The downtime was significantly shorter in the microneedling-treated side. There were no long-lasting or severe adverse effects after treatment with both methods. Conclusion: Microneedling and fractional Er:YAG laser have comparable efficacy in facial rejuvenation, but little downtime of the former makes it preferable for many patients.

    关键词： facial rejuvenation,fractional Er:YAG laser,wrinkle,microneedling

    更新于2025-09-23 15:21:01

  • The use of Carboxytherapy alone or in combination with fractional CO2 laser for facial rejuvenation: A splita??face comparative study

    摘要： Background A wide variety of minimally invasive treatments are available for skin aging. Recently carbon dioxide therapy (CDT) or carboxytherapy was used in many cosmetic indications including facial rejuvenation. Objective To compare the efficacy of CDT alone versus combined CDT and fractional CO2 laser in management of facial aging. Methods Twenty-Five female patients with bilateral and symmetrical facial aging were included in the study. The right (Rt) hemiface received 8 sessions of CDT whereas the left (Lt) side was treated with combined technique (6 sessions of CDT and 2 sessions of fractional CO2 in between. Clinical and objective evaluation using 3D skin analysis, histological and morphometric analysis were performed. Results Clinical evaluation demonstrated that all patients (100%) were satisfied with no significant difference between both sides of the face (p>0.05). Regarding texture and pigmentation improvement, the Lt side (combined) showed significant improvement compared to the Rt side (p<0.05). Using Antera 3D camera, there was a significant difference (p<0.05) in 3D improvement percent in textural changes while there was no significant difference (p>0.05) in the 3D percent of wrinkles improvement between both sides. The Lt. side showed more significant increase in epidermal thickness after treatment when compared to the Rt. side (p<0.05) with evident neocollagen formation. Conclusion Carboxytherapy is an easy, safe, simple and a relatively effective method for facial rejuvenation with minimal downtime. Better results were achieved when used in combination with fractional CO2 laser.

    关键词： skin aging,minimally invasive treatments,fractional CO2 laser,facial rejuvenation,Carboxytherapy

    更新于2025-09-23 15:21:01

  • Face and neck rejuvenation using an improved non-ablative fractional high power 1064-nm Q-switched Nd:YAG Laser: clinical results in 16 women

    摘要： Objective: To evaluate the safety and efficacy of a specific treatment protocol using a new and improved non-ablative fractional high-power 1064-nm Q-switched Nd:YAG laser for face and neck rejuvenation. Methods: Sixteen women, aged 30 to 60 years old, were selected to undergo three consecutive treatment sessions with this new laser at maximum energy (2,400 mJ/pulse, Clear Lift laser?-Harmony XL-Pro, Alma Lasers Ltd.). Face and neck were treated in eight patients, respectively. Each treatment used the same protocol. The efficacy was evaluated by the therapist (TS), the patient (PS), and two separate independent experts who were blind to the study (E1 and E2). Results: According to E1 and E2, the mean reduction in signs of skin aging on a Global Esthetic Improvement Scale was 30-40%. Using a 0–10 points scale, TS and PS mean (range) satisfaction rates were 9.0 (8–10); 9.2 (6–10) for the face and 8.7 (8–10); 8.0 (3–10), for the neck, respectively. The procedure was practically painless, no significant adverse effects were observed, and the patients returned to their daily and work activities without downtime. Conclusion: This laser was safe and effective for face and neck minimally invasive rejuvenation, with excellent results using our usual routine use conditions.

    关键词： fractionated laser,resurfacing,Q-Switched Nd:YAG laser,Skin rejuvenation,non-ablative laser

    更新于2025-09-23 15:19:57

  • Novel Use of Nona??Invasive Devices and Microbiopsies to Assess Facial Skin Rejuvenation Following Laser Treatment

    摘要： Patient‐reported outcomes and blinded observer rating scales are subjective and unreliable but are extensively utilized to evaluate cosmetic office‐based treatments, including ablative lasers. This study aims to assess the practicality of using non‐invasive and minimally invasive methods for objective skin assessment following a skin rejuvenation treatment. Twelve patients received a single 1,470/2,940 nm laser treatment for facial rejuvenation. Assessments were performed before treatment, and 7 days, 3 weeks, and 3 months post‐treatment. Images were taken with the VISIA Skin Analysis System to measure wrinkles, textures, pores, ultraviolet (UV) spots, brown spots, red areas, and porphyrins. Other non‐invasive skin measurements—high‐resolution ultrasonography, optical coherence tomography, transepidermal water loss and BTC 2000—were used to measure epidermal/dermal thickness, blood flow, surface roughness, wrinkle depth, attenuation coefficient, elasticity, viscoelasticity. Microbiopsies (0.33 mm in diameter or the equivalent of a 23‐gauge needle) were collected for histology and gene expression of tissue rejuvenation. Significant improvement in facial skin aesthetics after laser treatment was recorded in UV spots, brown spots and pores after 3 weeks and in UV spots and brown spots after 3 months. The dermal attenuation coefficient decreased significantly at 3 weeks, while blood flow 0.5 to 0.7 mm below the skin surface increased significantly between 5 days and 3 weeks following treatment. Epidermal hyaluronic acid expression assessed by immunostaining and expression of inflammatory genes were elevated at 7 days post‐treatment compared with untreated or 3 months post‐treatment. There were no statistically significant changes in collagen or elastin‐related genes between groups at the studied parameters. Non‐invasive devices can be effectively used to provide objective measurements of skin structure, pigmentation, blood flow, and elasticity to assess the efficacy of facial skin rejuvenation treatments. Furthermore, microbiopsies can objectively evaluate facial skin rejuvenation without scarring. Using non‐invasive skin imaging, a single treatment with the 1,470/2,940 nm laser was observed to be effective in improving skin appearance after 3 months, namely in reducing UV spots and brown spots, without significant changes in the tissue at the molecular level, as assessed by microbiopsy.

    关键词： non‐invasive,laser ablation,microbiopsy,skin biopsy,skin rejuvenation,skin imaging

    更新于2025-09-23 15:19:57

  • A Randomized, Splita??Face, Doublea??Blind Comparison Trial Between Fractionated Frequencya??Doubled 1064/532a??nm Picosecond Nd:YAG Laser and Fractionated 1927a??nm Thulium Fiber Laser for Facial Photorejuvenation

    摘要： Fractionated lasers are a popular therapeutic option for facial photorejuvenation. In this study, we compare the safety, tolerability, and efficacy of a fractionated frequency‐doubled 1064/532 nm picosecond Nd:YAG fractionated picosecond laser (FPL) versus a fractionated 1927 nm thulium fiber laser (TFL) for facial rejuvenation. This was a double‐blind, randomized, split‐face comparison study involving 20 subjects. Facial halves were randomized to receive either FPL or TFL treatment. Three treatments were delivered at 1‐month intervals. Subjects were followed up for 1, 3, and 6 months post‐final treatment session and evaluated by blinded, non‐treating investigators for dyspigmentation, erythema, keratosis, texture, and rhytids on a standardized scale. Subjects also recorded a quantitative daily diary rating healing progress for 14 days after every treatment session. Statistically significant improvements in elastosis, erythema, keratosis, dyschromia, and skin texture were noted in both treatment groups. There were no significant differences detected in clinical efficacy between the two groups. Subject daily diaries revealed statistically significant differences in tolerability during the immediate 14‐day post‐operative recovery period. The facial half treated with FPL displayed significantly less redness on days 3 and 4; significantly less swelling on day 5; significantly less crusting on days 1 through 9; significantly less peeling on days 3 through 9; and significantly less itch on days 4 and 7. There were no unexpected adverse effects observed. Both FPL and TFL are safe and effective treatment options for facial rejuvenation. FPL may be associated with significantly less downtime.

    关键词： photodamage,laser induced optical breakdown,photothermolysis,thulium fiber,picosecond laser,photoacoustolysis,Nd:YAG,holographic lens,clinical trial,rejuvenation

    更新于2025-09-19 17:13:59

  • [IEEE 2019 International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON) - Novosibirsk, Russia (2019.10.21-2019.10.27)] 2019 International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON) - Theoretical Substantiation for the Original Technique of Photodynamic Fractional Laser Photothermolysis (PFLP) for Dermatology, based on Intradermal Transport of Photosensibilisers

    摘要： This review demonstrates the progress, current status and problems of photodynamic therapy and laser photothermolysis for various skin diseases and rejuvenation. These new minimally invasive technologies are detailed from the points of view of their advantages and disadvantages. Particular attention is paid to complications, associated with prolonged dermal phototoxicity after insufficient intravenous intradermal penetration of photosensibilisers after local application to skin. Finding a compromise between phototoxicity and insufficiency of local photosensibilisation we've developed a technical approach employed to overcome of limitations associated with targeted delivery of photosensibilisers into deep dermal layers. Intradermal delivery of photosensibilisers through so-called microthermal zones or dermal micropores, formed by focused pulse-periodic radiation of fiber laser, previously never used for photodynamic therapy of dermal disorders.

    关键词： photodynamic therapy,intradermal transport,rejuvenation,drug delivery,skin diseases,photothermolysis

    更新于2025-09-19 17:13:59

  • Application du laser en uro-gynécologie?: alerte?!

    摘要： Le laser a e′te′ adopte′ avec un succe` s relatif pour le remodelage tissulaire des cicatrices et des rides. Par extension, ces re′ sultats ont conduit les industriels a` proposer son application dans un sous-groupe : ? le rajeunissement vulvovaginal ? inte′ grant pe?le-me?le l’atrophie vaginale, le lichen vulvovaginal, l’incontinence urinaire et le prolapsus ge′ nital. L’atrophie vaginale lie′ e a` l’hypoestroge′ nisme est reconnue comme une cause de morbidite′ des femmes me′ nopause′ es. En 2014, la de′ finition du ? syndrome ge′ nito-urinaire de la me′ nopause ? (GSM). Les modi?cations pre′ sente′ es apre` s laser sont compatibles avec des modi?cations d’une le′ sion thermique et les re′ sultats histologiques de′ ?nitifs n’ont pas de′ montre′ qu’ils induisaient la restauration de la fonction sexuelle. Dans la dysfonction sexuelle, une approche focalise′ e sur la ? muqueuse vaginale ? semble limite′ e et insuf?sante [1]. Les e′ tudes disponibles sur l’utilisation du laser pour traiter l’atrophie vaginale n’ont dans l’ensemble pas fourni de preuves suf?santes de l’ef?cacite′ et de la se′ curite′ a` long terme (niveau de preuve 3b, grade de recommandation C).

    关键词： Female urinary incontinence,Cosmetology,Marketting,Vaginal rejuvenation,Laser

    更新于2025-09-16 10:30:52

  • Fractional 1,927?nm Thulium Laser Plus Photodynamic Therapy Compared and Combined for Photodamaged Décolleté Skin: A Side‐by‐Side Randomized Controlled Trial

    摘要： Background and Objectives: Décolleté photodamage is a common condition typically treated with light and energy‐based devices. This study investigated the efficacy and safety of a fractional 1,927 nm thulium laser (TL) alone and combined with photodynamic therapy (PDT). Study Design/Materials and Methods: In a 12‐week follow‐up study, participant décolletés were divided into four treatment areas and randomized to receive a single treatment with field‐directed TL, PDT, combination TL‐PDT, or lesion‐directed curettage control. All actinic keratoses (AKs) underwent lesion‐directed curettage before randomization. TL was delivered at 20 mJ/mb, 500 mJ/cm2 fluence, 5 W, and 8 (n = 6 pts.) or 16 (n = 6 pts.) passes. PDT was performed with 16% methyl aminolevulinate (MAL) creme incubated for 3 h, followed by red light‐emitting diode light at 37 J/cm2. Outcome measures included clinical assessment of overall photodamage and specific subcomponents, assisted by optical coherence tomography (OCT) imaging. Results: Twelve women with moderate to severe photodamage on the décolleté and a cumulative total of 184 thin grade I AKs were included. Field‐directed treatments TL and combination TL‐PDT equally improved the overall photodamage, mottled pigmentation, and rhytides compared with lesion‐directed control (P < 0.05). The skin texture improved by TL alone and was further improved by combining TL and PDT (P < 0.05). Median AK complete responses were similar for field‐directed interventions TL‐PDT (100%), TL (90%), PDT (82%), and lesion‐directed curettage control (52%) (P = 0.464). Patients presented with mild local skin responses, slightly more pronounced when combining TL with PDT versus individual treatments (P < 0.05). No scarring or adverse events were observed. Conclusions: The 1,927 nm fractional thulium laser is an effective, tolerable, and safe field‐directed treatment for décolleté photodamage. Provided alone, TL proved to be as effective as combined TL‐PDT for overall photodamage, while a greater improvement in skin texture was achieved using TL and PDT in combination.

    关键词： décolleté,optical coherence tomography,skin photodamage,thulium laser,non‐ablative laser,actinic keratosis,skin rejuvenation,photodynamic therapy

    更新于2025-09-12 10:27:22

  • Topical Nanofat Biocrème Improves Aesthetic Outcomes of Nonablative Fractionated Laser Treatment: A Preliminary Report

    摘要： Background: Improvements in skin erythema and elasticity have been seen with topical application of platelet-rich plasma after fractional laser treatment. Nanofat, when injected in small needles into the dermis has shown improvements in tissue thickness, discoloration and wrinkle depth. Objective: To evaluate improvements in skin following a nonablative fractional laser (FXD) treatment combined with the application of a novel topical nanofat biocrème, called neo-U. Methods: Fifty patients were treated with a nonablative FXD followed by application of a topical nanofat biocrème. Harvested fat was processed into nanofat, which was compounded with a transdermal liposomal delivery vector to produce a topical biocrème. In two patients, post-auricular skin punch biopsies were performed pre/post-treatment and examined for histological changes. Photos of a historical group treated with only the FXD laser were compared to photos of the patients treated with topical nanofat biocrème and a FXD laser. Results: Findings from postauricular skin biopsies show the skin exposed to FXD with nanofat biocrème had more elastin fibers and a slight increase in the thickness of the epidermis. Patients having FXD plus nanofat biocrème had a statistically significant improvement in the degree of wrinkles, nasolabial fold depth and texture compared to historical controls. Conclusions: Transdermal delivery of nanofat topical biocrème applied after fractional laser treatment can serve as a delivery system to improve fine lines, depth of nasolabial folds and overall texture of the tissue to a greater degree than laser resurfacing alone.

    关键词： fractional laser,nanofat,transdermal delivery,skin rejuvenation,biocrème

    更新于2025-09-11 14:15:04

  • Reflections on the Er:YAG Laser Used in “Nonthermal Mode” to Rejuvenate Skin

    摘要： CO2 and Er:YAG lasers are both actively used for laser skin rejuvenation, both ablative and microablative. Despite seeming similarities in efficiency of their radiation’s absorption by soft tissues, these lasers may have completely different effects on skin: tissue vaporization with CO2 laser radiation always assumes existence of areas with irreversible thermal effects such as coagulation, dehydration, carbonization, and vaporization. If Er:YAG and vaporization is used for the same purpose, same thermal damage areas may be obtained but smaller in size. However, in case of sufficiently high energy density and short duration of pulses, an ablation mode may be implemented, in the case in which areas of irreversible thermal changes are contained within vaporization zone. Thus, underlying layers of irradiated tissue are not thermally damaged.

    关键词： ablation mode,cavitation,Er:YAG laser,microablation,CO2 laser,skin rejuvenation,thermal damage

    更新于2025-09-11 14:15:04