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Growth, spectroscopic, diode-pumped mid-infrared laser properties of Er:GSAG crystal
摘要： A great potential mid-infrared laser crystal of heavily Er3+ doped GSAG crystal with high optical quality is successfully grown by Cz method. The crystal quality of Er:GSAG crystal is determined by XRC. The structure parameters of Er:GSAG crystal are obtained by the X-ray Rietveld refinement method (a=b=c=12.3196?). The absorption cross section at 961nm and 967 nm are 0.381 × 10-21 cm2 and 0.414 × 10-21 cm2, respectively. The 962 nm laser diode end-pumped Er:GSAG laser operated at 2828 nm is demonstrated for the first time. The performance of Er:GSAG laser is investigated in great detail. A maximum output power of Er:GSAG laser is 410 mW when pumped by 962 nm LD at 300 Hz and 0.5 ms. Simulating results display the highest temperatures of Er:GSAG laser spot is 345.8 K, indicating a small thermal lensing effect of Er:GSAG crystal. Besides, the laser performance of Er:GSAG crystals which irradiate by different doses of gamma-ray are used to investigated its potential for working in the radiation resistance environment. The results show the relatively minor differences on the Er:GSAG lasers performance, indicating a great potential of Er:GSAG crystal in radiant environment application.
关键词： Er:GSAG,Mid-infrared laser,Radiation resistant,Crystal structure,Absorption spectrum
更新于2025-09-11 14:15:04
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Efficacy of Multiple Dexamethasone Intravitreal Implants for Refractory Retinal Vein Occlusion-Related Macular Edema and Effect of Prior Vitrectomy
摘要： Purpose: To evaluate the efficacy of dexamethasone intravitreal implants (DEX implant) in patients with treatment-resistant macular edema (ME) owing to branch and central retinal vein occlusion (BRVO/CRVO), and the influence of prior vitrectomy on this treatment. Methods: Multicenter retrospective chart review was performed on 40 CRVO and 32 BRVO eyes with persistent ME despite intravitreal anti-vascular endothelial growth factor agents and/or intravitreal triamcinolone, and/or laser therapy. Each patient received ?1 dexamethasone 700 lg implant between March 2011 and December 2015. Thirteen patients underwent prior vitrectomy. Data were collected on best-corrected visual acuity (BCVA), central macular thickness (CMT), time to relapse, and adverse events. Results: At the end of follow-up, BRVO eyes had a lesser CMT reduction from baseline compared to CRVO eyes (-122.50 – 152.47 mm and -202.26 – 194.09 mm, respectively). Neither BRVO nor CRVO eyes had a (P = 0.7041 and P = 0.7027, respectively). Vitrectomized and nonvitrectomized eyes sustained BCVA benefit the study with -192.46 – 172.62 mm and -164.02 – 180.36 mm, respectively, at final follow-up. Similar time to relapse of 24.4 – 6.5 and 23.3 – 13.5 weeks, respectively, was observed. By the end of follow-up, BCVA had only improved in vitrectomized eyes. However, multivariable regression analyses showed no significant association between vitrectomy status and CMT or BCVA change after the first and last injection. Cataract formation and ocular hypertension occurred in 25% and 17%, respectively. Conclusions: Multiple DEX implant are effective in reducing CMT in patients resistant to previous treatments and appear to be similarly effective in vitrectomized and nonvitrectomized eyes.
关键词： macular edema,vitrectomy,dexamethasone,retinal vein occlusion,Ozurdex,treatment-resistant
更新于2025-09-11 14:15:04
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A Synthetic Fluorescent Nanoplatform Based on Benzoxaborole for Broad-Spectrum Inhibition of Bacterial Adhesion to Host Cells
摘要： The rising prevalence of antibiotic-resistant bacteria pathogens has attracted increasing concern in the whole world. The anti-adhesion strategy without triggered bacterial resistance is currently considered a promising alternative to treat bacteria-induced infections. Here, we developed a novel bacteria-binding florescent polymeric nanoplatform for non-lethal anti-adhesion therapy of bacterial infections. This versatile platform will allow simultaneous bacterial agglutination and fluorescent reporting for both Gram-positive and Gram-negative bacteria by taking advantage of strong interaction between the benzoxaborole groups and diol moieties on bacterial surfaces. Furthermore, impressive performance of inhibiting biofilm formation was entirely shown in the generic cell-binding glues. The trapping nanoparticles were capable of taking invasive bacteria pathogens away from the infected host cells with negligible damage to neither bacterial nor host cells, which will not trigger drug resistance, indicating a far-reaching future of the potential application for anti-adhesion therapy of whole-bacterial infection diseases.
关键词： biofilm inhibition,fluorescent polymeric nanoplatform,anti-adhesion therapy,benzoxaborole,antibiotic-resistant bacteria
更新于2025-09-10 09:29:36
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Effects of inclination angle on surface roughness and corrosion properties of selective laser melted 316L stainless steel
摘要： Balling effect is an inevitable defect during Selective laser melting (SLM) process, and it deteriorates the mechanical and corrosion properties of the resulting parts. In this work, the SLM process is used with various inclination angles to fabricate samples. The deep relationship between the selective laser melting process and the corrosion properties of the as-SLM fabricated parts is established to understand the effect of the inclination angle on the surface roughness, microstructure evolution, and corrosion properties of 316L stainless steel components. Results show that the Ra value of fabricated parts increased with increasing inclination angles. Inclination angles play an important role in balling and defect formation. Fabricated parts exhibit a wide passive region in salty environments. The corrosion resistance of the SLM samples after polishing is decreased comparing to that of the unpolished which attribute to porosity and balling behavior. The typical corrosion characterization of polished surface is pitting and localized corrosion, and it mainly origin of pores and balling. Meanwhile, balling behavior accelerated corrosion rates of non-polished parts.
关键词： Selective laser melting,Inclination angles,Surface roughness,Corrosion resistant
更新于2025-09-09 09:28:46
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Radiation-induced loss of silica optical fibres with fluorine-doped cladding
摘要： The effect of gamma-irradiation of the fluorine-doped silica depressed cladding graded-index fibre (DCGIF) has been researched. New mechanism of the non-bridging oxygen hole centers (NBOHC) defect formation, conditioned by different mobility of diffusion counter flows of fluorine and oxygen at the core-cladding interface, has been proposed. Using silica tubes with 0.02 wt% of OH groups and hydrogen in free state in MCVD-technology of DCGIF fabrication completely eliminates the NBOHC absorption at the wavelength of 630 nm. However, gamma-irradiation of such fibres results in anomalously high attenuation level in the visible range of optical spectrum. It was established that irradiation of DCGIF leads to light scattering which is probably due to the appearance of optical inhomogeneities in the glass matrix.
关键词： fibre optics,Rayleigh scattering,fibre design and fabrication,radiation-resistant optical fibres
更新于2025-09-09 09:28:46
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Back-Channel-Etched Thin-Film Transistors With Tunable Acid-Resistant Zr-Doped Indium Oxide Active Layer
摘要： In this paper, a tunable acid-resistant Zr-doped indium oxide (ZrInO) semiconductor material was developed. Detailed studies showed that the acid resistance of ZrInO thin films is tunable and increases with the increase in annealing temperature. Taking advantage of this special property, we successfully fabricated back-channel-etched (BCE) thin-film transistors (TFTs) based on the tunable acid-resistant ZrInO thin film. ZrInO-TFTs with BCE structure exhibited excellent electrical performance with a saturation mobility of 21.4 cm2V?1s?1, a subthreshold swing of 0.28 V/decade, and an on/off current ratio of 1.0 × 107. These results envision that the developed ZrInO semiconductor with tunable acid resistance has a good prospect for the channel layer of BCE-TFTs.
关键词： oxide semiconductor,Anodic Al2O3,tunable acid-resistant Zr-doped indium oxide (ZrInO),back-channel etch (BCE),thin-film transistors (TFTs)
更新于2025-09-09 09:28:46
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A Photon-Responsive Antibacterial Nanoplatform for Synergistic Photothermal-/Pharmaco- Therapy of Skin Infection
摘要： Abuse of antibiotics and their residues in the environment result in the emergence and prevalence of drug-resistant bacteria and lead to serious health problems. Herein, a photon-controlled antibacterial platform that can efficiently kill drug-resistant bacteria and avoid the generation of new bacterial resistance was designed by encapsulating black phosphorus quantum dots (BPQDs) and pharmaceutical inside a thermal-sensitive liposome. The antibacterial platform can release pharmaceutical in a spatial-, temporal- and dosage-controlled fashion since the BPQDs can delicately generate heat under near-infrared (NIR) light stimulation to disrupt the liposome. This user-defined delivery of drug can greatly reduce the antibiotic dosage, thus avoiding the indiscriminate use of antibiotics and preventing the generation of superbugs. Moreover, by coupling the photothermal effect with antibiotics, this antibacterial platform achieved a synergistic photothermal-/pharmaco- therapy with significantly improved antibacterial efficiency towards drug-resistant bacteria. The antibacterial platform was further employed to treat antibiotic-resistant bacteria-caused skin abscess and it displayed excellent antibacterial activity in vivo, promising its potential clinical applications. Additionally, the antibacterial mechanism was further investigated. The developed photon-controlled antibacterial platform can open new possibilities for avoiding bacterial resistance and efficiently killing antibiotic-resistant bacteria, making it valuable in fields ranging from anti-infective therapy to precision medicine.
关键词： black phosphorus,drug-resistant bacteria,skin abscess,liposome,photothermal therapy
更新于2025-09-09 09:28:46
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Improvement in infected wound healing in type 1 diabetic rat by the synergistic effect of photobiomodulation therapy and conditioned medium
摘要： We investigated the effects of photobiomodulation therapy (PBMT) and conditioned medium (CM) of human bone marrow mesenchymal stem cells (hBM‐MSC) individually and/or in combination on the stereological parameters and the expression of basic fibroblast growth factor (bFGF), hypoxia‐inducible factor (HIF‐1α), and stromal cell–derived factor‐1α (SDF‐1α) in a wound model infected with methicillin‐resistant Staphylococcus aureus (MRSA) in diabetic rats. CM was provided by culturing hBM‐MSCs. Type 1 diabetes mellitus (T1DM) was induced in 72 rats, divided into four groups, harboring 18 rats each: group 1 served as a control group, group 2 received PBMT, group 3 received CM, and group 4 received CM + PBMT. On days 4, 7, and 15, six animals from each group were euthanized and the skin samples were separated for stereology examination and gene expression analysis by real‐time polymerase chain reaction. In the CM + PBMT, CM, and PBMT groups, significant decreases were induced in the number of neutrophils (1460 ± 93, 1854 ± 138, 1719 ± 248) and macrophages (539 ± 69, 804 ± 63, 912 ± 41), and significant increases in the number of fibroblasts (1073 ± 116, 836 ± 75, 912 ± 41) and angiogenesis (15 230 ± 516, 13 318 ± 1116, 14 041 ± 867), compared with those of the control group (2690 ± 371, 1139 ± 145, 566 ± 90, 12 585 ± 1219). Interestingly, the findings of the stereological examination in the CM + PBMT group were statistically more significant than those in the other groups. In the PBMT group, in most cases, the expression of bFGF, HIF‐1α, and SDF‐1α, on day 4 (27.7 ± 0.14, 28.8 ± 0.52, 27.5 ± 0.54) and day 7 (26.8 ± 1.4, 29.6 ± 1.4, 28.3 ± 1.2) were more significant than those in the control (day 4, 19.3 ± 0.42, 25.5 ± 0.08, 22.6 ± 0.04; day 7, 22.3 ± 0.22, 28.3 ± 0.59, 24.3 ± 0.19) and other treatment groups. The application of PBMT + CM induced anti-inflammatory and angiogenic activities, and hastened wound healing process in a T1 DM model of MRSA infected wound.
关键词： stereology,diabetes mellitus,diabetic foot ulcer,methicillin‐resistant staphylococcal aureus,low‐level laser therapy,phobiomodulation therapy,human bone marrow mesenchymal stem cell‐conditioned medium,real‐time PCR,rat
更新于2025-09-04 15:30:14
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Bend resistant large mode area fiber with step-index core and single trench
摘要： A novel bend resistant large mode area ?ber with step-index core and single trench in the cladding is proposed. Numerical results demonstrate that the largest e?ective mode area reaches up to 2460 μm2 at the wavelength of 2 μm when the bend radius is only 10 cm. To achieve the better performance of single mode, the loss ratio of the lowest loss of higher order mode to the highest loss of fundamental mode can reach up to 886 with a fundamental mode bend loss lower than 0.0083 dB/m through optimizing structure parameters. The circular symmetry of ?ber structure makes it insensitive to the bending direction. Furthermore, this ?ber structure can be also used to develop bend resistant large mode area ?ber with high performance at the wavelengths of 1.06 μm and 1.55 μm. Due to large mode area, good single mode properties, small bend radius and insensitivity to bend direction, this ?ber has the potential application for compact high power ?ber lasers.
关键词： Bend resistant,Large mode area ?bers,Loss ratio,Single mode
更新于2025-09-04 15:30:14
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Regenerated fiber Bragg grating sensing system for ultrasonic detection in a 900 °C environment
摘要： Heat-resistant composites, such as ceramic matrix composites (CMCs) and heat-resistant carbon fiber reinforced plastics (CFRPs), are expected to be used for aircraft engine parts. The development of reliable heat-resistant composite materials requires the use of nondestructive test (NDT) techniques for evaluating the progression of damage during material testing at elevated temperatures. Furthermore, structural health monitoring (SHM) technologies that operate under harsh environments are expected to be realized for monitoring heat-resistant composite structures. To provide potential solutions for the establishment of such technologies, this research developed a heat-resistant ultrasonic sensor based on a regenerated fiber-optic Bragg grating (RFBG). First, we fabricated an RFBG by annealing a normal FBG sensor. Because the RFBG exhibits high heat resistance at temperatures of 1000 °C, the sensor achieved stable ultrasonic detection at an elevated temperature. In addition, we attempted to use a π-phase-shifted FBG (PSFBG) as the seed grating to construct an ultrasonic sensor with enhanced performance. As a result, the R(PS)FBG sensor possessed a very short effective gauge length and achieved a broad frequency response to ultrasonic waves with frequencies greater than 1.5 MHz. The broadband detectability enables the R(PS)FBG sensor to acquire an accurate response to ultrasonic waves. Hence, we believe the regenerated Bragg grating-based ultrasonic sensors can contribute to establishing an effective nondestructive evaluation method for composite materials, thereby enabling a structural health monitoring system for a composite-made structure operating under extreme high-temperature environments.
关键词： structural health monitoring (SHM),ultrasonic detection,nondestructive test (NDT),regenerated fiber-optic Bragg grating (RFBG),high-temperature environment,Heat-resistant composites
更新于2025-09-04 15:30:14