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Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy
摘要： Objective: To assess the recurrent rate, mean survival time, and risk factors associated with recurrent painful bullous keratopathy (BK) after primary treatment with phototherapeutic keratectomy. Methods: Medical records from 72 patients (72 eyes) who had phototherapeutic keratectomy for painful BK were evaluated. Data for sex, age, duration of BK, associated ocular and systemic diseases (hypertension, diabetes mellitus, ischemic heart disease, asthma, dyslipidemia, and rheumatoid arthritis), frequency and degree of pain (grade 1–3), visual acuity, corneal thickness, intraocular pressure, and laser setting were extracted and analyzed. Results: The mean age of the patients was 64.2±11.4 years. The mean preoperative duration of BK was 15.0±11.0 months. Most patients had pseudophakic BK (69.40%). Majority of the cases had grade 3 degree of pain (48.60%). Glaucoma and hypertension were markedly found among these patients (51.40% and 19.40%, respectively). Preoperative mean intraocular pressure and corneal thickness were 13.70±4.95 mmHg and 734.1±83.80 μm, respectively. The mean laser diameter and depth were 8.36±1.22 mm and 38.89±8.81 μm, respectively. Systemic disease was significantly associated with the risk for developing recurrent painful BK (P=0.022, hazard ratio [HR] 1.673, 95% confidence interval [CI] 1.08–2.58). The overall recurrent rate was 51%. The average duration time of recurrent painful BK was 17.3±12.9 months (range 1–50 months). The median survival time before recurrence was 29.0±6.6 months. Conclusion: Systemic disease was found to be the only risk factor significantly associated with the development of recurrent painful BK. Low recurrent rate and long mean survival time showed that phototherapeutic keratectomy was effective in relieving recurrent painful BK and can be used as an alternative procedure for patients waiting for corneal transplantation.
关键词： mean survival time,phototherapeutic keratectomy,PTK,recurrent painful,bullous keratopathy,risk factor
更新于2025-09-04 15:30:14
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[IEEE 2018 IEEE International Conference on Environment and Electrical Engineering and 2018 IEEE Industrial and Commercial Power Systems Europe (EEEIC / I&CPS Europe) - Palermo (2018.6.12-2018.6.15)] 2018 IEEE International Conference on Environment and Electrical Engineering and 2018 IEEE Industrial and Commercial Power Systems Europe (EEEIC / I&CPS Europe) - Simplified Assessment of Blue Light Emissions based on Photometric Measurements
摘要： The human-luminous environment interaction is a topic of interest to the scientific community from the perspectives of comfort and health. The widespread introduction of innovative lighting sources, often justified by energy-saving reasons, poses new challenges for evaluating their emissions and estimating their photobiological effects. In this paper, the results of a measurement campaign to characterize the artificial optical radiation emitted by LED sources suitable for replacing traditional sources used in general lighting are discussed and compared with similar results obtained for fluorescent tubes. The evaluation methods described and the measurement results shown in this paper can be useful for those who regularly perform risk assessments of work environments.
关键词： General lighting systems,Risk group classification,Artificial optical radiation,LED sources,Blue light emission
更新于2025-09-04 15:30:14
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Risk analysis using meteorological weather factors in solar energy conversion systems
摘要： We propose a methodology for conducting simulations of operational scenarios for energy projects based on photovoltaic generation systems. It considers several documented facts about time series of weather, such as strong seasonality and structural breaks, which the previous literature has not explored in depth. Our proposal uses public weather time series, which are usually recorded by meteorological observatories. This makes our approach a suitable strategy for any firm interested in applying it to its own data and projects. This approach also allows the user to set an appropriate level of confidence for the scenarios depending on her interests.
关键词： renewable energy sources,photovoltaic systems,risk measurement,structural breakpoints,horizontal solar radiation
更新于2025-09-04 15:30:14
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Flow cytometry for fast screening and automated risk assessment in systemic light-chain amyloidosis
摘要： Early diagnosis and risk stratification are key to improve outcomes in light-chain (AL) amyloidosis. Here we used multidimensional-flow-cytometry (MFC) to characterize bone marrow (BM) plasma cells (PCs) from a series of 166 patients including newly-diagnosed AL amyloidosis (N = 94), MGUS (N = 20) and multiple myeloma (MM, N = 52) vs. healthy adults (N = 30). MFC detected clonality in virtually all AL amyloidosis (99%) patients. Furthermore, we developed an automated risk-stratification system based on BMPCs features, with independent prognostic impact on progression-free and overall survival of AL amyloidosis patients (hazard ratio: ≥ 2.9;P ≤ .03). Simultaneous assessment of the clonal PCs immunophenotypic protein expression profile and the BM cellular composition, mapped AL amyloidosis in the crossroad between MGUS and MM; however, lack of homogenously-positive CD56 expression, reduction of B-cell precursors and a predominantly-clonal PC compartment in the absence of an MM-like tumor PC expansion, emerged as hallmarks of AL amyloidosis (ROC-AUC = 0.74;P < .001), and might potentially be used as biomarkers for the identification of MGUS and MM patients, who are candidates for monitoring pre-symptomatic organ damage related to AL amyloidosis. Altogether, this study addressed the need for consensus on how to use flow cytometry in AL amyloidosis, and proposes a standardized MFC-based automated risk classification ready for implementation in clinical practice.
关键词： bone marrow,plasma cells,light-chain amyloidosis,risk assessment,flow cytometry
更新于2025-09-04 15:30:14