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Impedimetric sensor for tyramine based on gold nanoparticle doped-poly(8-anilino-1-naphthalene sulphonic acid) modified gold electrodes
摘要： A novel impedimetric sensor for the determination of tyramine (Tyr), a biogenic amine, on the surface of gold nanoparticle-poly-(8-anilino-1-napthalene sulphonic acid), AuNP-PANSA modified gold electrode (AuE) is presented for the first time. The AuNP were successfully synthesized by a green synthesis method. Their characterization and optimization were conducted using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, electrochemical impedance spectroscopy and cyclic voltammetry. Under optimal conditions, the impedimetric sensor revealed a relatively broad linear range from 0.8 to 80 μM similar to more complex architectures found in the literature and the limit of detection of 0.04 μM was the lowest achieved until now. In order to test the reliability of the proposed method, real sample application studies were conducted using dairy products and fermented drinks. It was found that the sensor presented a good selectivity and recovery. Furthermore, the impedimetric sensor shows good reproducibility, stability, selectivity and very small interferences which augur well for its application in food safety control processes.
关键词： electrochemical impedance detection,food safety control,impedimetric sensor,biogenic amine,tyramine
更新于2025-09-09 09:28:46
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Intraoperative Thermography of the Electrical Stimulation Mapping: A Safety Control Study
摘要： A standard procedure for continuous intraoperative monitoring of the integrity of the corticospinal tracts by eliciting muscle responses is the electric stimulation mapping (ESM). However, standard ESM protocols are ineffective in 20% of young children. We have developed a novel, highly efficient paradigm consisting of short-time burst (30 ms) of high frequency (500 Hz) and high peak current (≤100 mA), which may cause local tissue overheating. The presented safety control study was therefore designed. The infrared thermography camera captured to-be-resected cortex of 13 patients in vivo during ESM. Thermograms were image processed to reveal discrete ESM thermal effect of currents from 10 to 100 mA. Peak 100 mA currents induced a maximal increase in temperature of 3.1 °C, 1.23 ± 0.72 °C in average. The warming correlated with stimulating electrode resistance (p < 0.001). The measurement uncertainty was estimated ±1.01 °C for the most skeptical conditions. The histopathological evaluation of stimulated tissue (performed in all cases) did not show any destructive changes. Our study demonstrates the ability of the thermographic camera to measure the discrete thermal effect of the ESM. The results provide evidence for the safety of the proposed protocol for full range currents with minimal risk of brain tissue damage.
关键词： neurosurgery,safety control,Electrical stimulation mapping,thermography,thermal effect,in vivo
更新于2025-09-09 09:28:46