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Test–Retest Repeatability of Microperimetry at the Border of Deep Scotomas
摘要： PURPOSE. The purpose of this study was to examine the test–retest repeatability of microperimetric sensitivity at the border of deep scotomas. METHODS. Thirty normal participants underwent two examinations, each on the Macular Integrity Assessment (MAIA) microperimeter and on the MP-1 microperimeter (four examinations in total). A customized stimulus pattern allowed microperimetric sensitivity to be measured at the border of the optic nerve head (ONH), which acted as a model for the border of a deep scotoma—and also at the macular and peripapillary region. RESULTS. There were no significant changes in average point-wise sensitivity (PWS) values between the two examinations for all three regions using the MAIA microperimeter (P ≥ 0.262). The PWS coefficient of repeatability (CoR) was ±12.99 dB at the border of the ONH, which was significantly larger than points in the macular and peripapillary regions (P > 0.001). A significant decrease in average PWS, using the MP-1 microperimeter at the macular and peripapillary region (P < 0.001), meant that the PWS CoR could not be determined in these regions. No significant changes in average PWS were observed at the border of the ONH (P = 0.223), and the PWS CoR was ±7.52 dB in this region. CONCLUSIONS. Microperimetric test–retest repeatability at the border of a deep scotoma was worse than at other areas of normal retina, and this highlights the limitation of applying a single estimate of test–retest repeatability to determine whether significant functional decline has occurred at the border of a deep scotoma.
关键词： repeatability,test–retest,microperimetry,scotoma
更新于2025-09-19 17:15:36
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Analyse glaukombedingter Makulaver?nderungen mittels optischer Koh?renztomografie
摘要： Background In glaucoma, progressive retinal nerve fibre loss can be measured in the peripapillary and macular regions using optical coherence tomography (OCT). The goal of this study was to evaluate the impact of glaucoma on all measurable retinal layers using the spectral domain OCT (SD-OCT). Materials and Methods SD-OCT scans using automated retinal layer segmentation were performed in both eyes of primary open-angle glaucoma patients with strictly monocular absolute visual field scotoma in the central 10° of their visual field. The same measurements were performed in one eye per person in a healthy age-matched control group. The mean thickness of all retinal layers in the central 24 × 24° of the macular region was compared between groups. Results SD-OCT scans were performed in 24 eyes of 12 glaucoma patients (10 female, 2 male) with a mean age of 72.3 ± 8.1 years and in 12 eyes of 12 healthy controls (9 female, 3 male) with a mean age of 66.0 ± 7.6 years. Statistically significant thickness differences between the glaucomatous and the healthy eyes could be demonstrated for the retinal nerve fibre layer, the ganglion cell layer, the inner plexiform layer and the complete retinal thickness, with lower mean thicknesses in the glaucoma group. Conclusion Using SD-OCT, single retinal layers of the macular region can be scanned and measured automatically. In glaucoma, a decrease in thickness of the inner retinal layers containing ganglion cells and their axons or dendrites could be demonstrated compared to healthy eyes. No corresponding difference in thickness could be found for the outer retinal layers using SD-OCT measurements.
关键词： scotoma,retina,glaucoma,optical coherence tomography,macula
更新于2025-09-19 17:15:36
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Progressive Visusminderung bei Zapfendystrophie. Spurensuche im Makula-OCT und Multifokal-ERG; Progressive loss of vision in cone dystrophy. Search for evidence with macular OCT and multifocal ERG;
摘要： A 53-year-old patient consulted our practice clinic complaining of progressive visual loss, increased glare sensitivity and color sense disorder. Extensive diagnostic investigation, including multifocal ERG (mfERG) and macular thickness map with the help of optical coherence tomography (OCT), supported the suspected diagnosis of a cone dystrophy. There are, however, no established therapeutic options. A diagnostic confirmation by means of molecular genetics was not successful.
关键词： Molecular genetics,Central scotoma,Glare sensitivity,Macular thickness map,Color sense disorder
更新于2025-09-04 15:30:14