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Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks
摘要： Current methods for cancer detection rely on tissue biopsy, chemical labeling/staining, and examination of the tissue by a pathologist. Though these methods continue to remain the gold standard, they are non-quantitative and susceptible to human error. Fourier transform infrared (FTIR) spectroscopic imaging has shown potential as a quantitative alternative to traditional histology. However, identification of histological components requires reliable classification based on molecular spectra, which are susceptible to artifacts introduced by noise and scattering. Several tissue types, particularly in heterogeneous tissue regions, tend to confound traditional classification methods. Convolutional neural networks (CNNs) are the current state-of-the-art in image classification, providing the ability to learn spatial characteristics of images. In this paper, we demonstrate that CNNs with architectures designed to process both spectral and spatial information can significantly improve classifier performance over per-pixel spectral classification. We report classification results after applying CNNs to data from tissue microarrays (TMAs) to identify six major cellular and acellular constituents of tissue, namely adipocytes, blood, collagen, epithelium, necrosis, and myofibroblasts. Experimental results show that the use of spatial information in addition to the spectral information brings significant improvements in the classifier performance and allows classification of cellular subtypes, such as adipocytes, that exhibit minimal chemical information but have distinct spatial characteristics. This work demonstrates the application and efficiency of deep learning algorithms in improving the diagnostic techniques in clinical and research activities related to cancer.
关键词： tissue classification,spatial features,convolutional neural networks,deep learning,spectral features,FTIR histology
更新于2025-09-19 17:15:36
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Spatial–Spectral Feature Fusion Coupled with Multi-Scale Segmentation Voting Decision for Detecting Land Cover Change with VHR Remote Sensing Images
摘要： In this article, a novel approach for land cover change detection (LCCD) using very high resolution (VHR) remote sensing images based on spatial–spectral feature fusion and multi-scale segmentation voting decision is proposed. Unlike other traditional methods that have used a single feature without post-processing on a raw detection map, the proposed approach uses spatial–spectral features and post-processing strategies to improve detecting accuracies and performance. Our proposed approach involved two stages. First, we explored the spatial features of the VHR remote sensing image to complement the insu?ciency of the spectral feature, and then fused the spatial–spectral features with di?erent strategies. Next, the Manhattan distance between the corresponding spatial–spectral feature vectors of the bi-temporal images was employed to measure the change magnitude between the bi-temporal images and generate a change magnitude image (CMI). Second, the use of the Otsu binary threshold algorithm was proposed to divide the CMI into a binary change detection map (BCDM) and a multi-scale segmentation voting decision algorithm to fuse the initial BCDMs as the ?nal change detection map was proposed. Experiments were carried out on three pairs of bi-temporal remote sensing images with VHR remote sensing images. The results were compared with those of the state-of-the-art methods including four popular contextual-based LCCD methods and three post-processing LCCD methods. Experimental comparisons demonstrated that the proposed approach had an advantage over other state-of-the-art techniques in terms of detection accuracies and performance.
关键词： very high resolution,spatial–spectral features,bi-temporal remote sensing images,land cover change detection,multi-scale segmentation
更新于2025-09-11 14:15:04
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Introduction to Special issue on Geologic Remote Sensing
摘要： Herein we provide an overview of science and technology involved in remote sensing, and outlines some practical constraints in applications to geological problems. We further summarize diagnostic spectral features of important geological material that can be detected using satellite- and air-borne remote sensing. Finally, the papers contained in the special issue are briefly introduced.
关键词： Geologic Remote Sensing,Spectral Features,Hyperspectral Remote Sensing,LANDSAT,ASTER
更新于2025-09-09 09:28:46