NOVEL MATRIX SUBLIMATION DEVICE FOR MALDI MASS SPECTROMETRY IMAGING

摘要： Sublimation is a widely used method for matrix deposition in imaging mass spectrometry experiments. Still, most of the time standard glass sublimators are used for this purpose, which do not enable optimal matrix deposition reproducibility, compromising inter-experiment comparison of the results. Here we present an in-house designed stainless steel sublimator in which the parameters that have the strongest influence over matrix deposition reproducibility can be easily monitored. Using sections of human colon biopsies we demonstrate the capabilities of this new prototype.