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Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density
摘要： Purpose: To assess the relationship between combined serum lutein and zeaxanthin (L+Z) concentration and macular pigment optical density (MPOD), and to investigate the effect of L+Z+docosahexaenoic acid (DHA) dietary supplementation on the spatial distribution of MPOD. Methods: Twenty healthy fellow eyes with unilateral wet age-related macular degeneration or chronic central serous chorioretinopathy were included. All participants received a dietary supplement for 6 months that contained 20 mg L, 1 mg Z, and 200 mg DHA. The best-corrected visual acuity and contrast sensitivity (CS) were measured at baseline and at 1, 3, and 6 months. Serum L+Z concentrations were measured at baseline and at 3 months. MPOD was calculated at each time point using fundus autofluorescent images. Results: Serum L+Z concentration was correlated with MPOD at 1°–2° eccentricity at baseline (r=0.63, P=0.003) and 3 months (r=0.53, P=0.015). Serum L+Z concentration increased by a factor of 2.3±1.0 (P<0.0001). At 6 months, MPOD was significantly higher compared to the baseline level at 0°–0.25° (P=0.034) and 0.25°–0.5° (P=0.032) eccentricity. CS improved after 3 or 6 months of L+Z+DHA supplementation (P<0.05). Conclusion: Juxtafoveal MPOD was associated with serum L+Z concentration. Foveal MPOD was increased by L+Z+DHA dietary supplementation.
关键词： fundus autofluorescence,spatial distribution,supplement
更新于2025-09-23 15:22:29
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Development of sulfur doped carbon quantum dots for highly selective and sensitive fluorescent detection of Fe2+ and Fe3+ ions in oral ferrous gluconate samples
摘要： Sulfur-doped carbon quantum dots (S-CQDs) with stable blue fluorescence were synthesized through a facile one-step hydrothermal method by using ascorbic acid and thioglycolic acid as carbon and sulfur sources. The prepared S-CQDs exhibited a sensitive and selective response to Fe3+ ions in comparison with Fe2+ and other metal ions, In the presence of adequate H2O2, Fe2+ was completely transformed to Fe3+ that is the determinable form of iron ions, and the difference in the change of the fluorescence intensity of S-CQDs before and after adding H2O2 was used for detection of Fe2+ ions, respectively. Under the optimum experimental conditions, the fluorescence intensity of S-CQDs gradually decreased with increasing of Fe3+ concentration ranging from 0 to 200 mM. Good linearity was achieved over the range of 0-200 mM. The detection limit of the developed method was 0.050 mM for Fe3+. The recoveries of Fe2+ spiked in real samples ranged from 98.2% to 112.4%. Finally, the proposed S-CQDs integrated with Fenton system was applied to the detection of Fe2+ and Fe3+ ions in oral ferrous gluconate samples, which presents potential applications in the speciation and determination of Fe2+ and Fe3+ ions in complex samples.
关键词： Fluorescence quenching,Iron supplement,Iron,Sulfur co-doped,Carbon quantum dot
更新于2025-09-19 17:13:59
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A Dermonutrient Containing Special Collagen Peptides Improves Skin Structure and Function: A Randomized, Placebo-Controlled, Triple-Blind Trial Using Confocal Laser Scanning Microscopy on the Cosmetic Effects and Tolerance of a Drinkable Collagen Supplement
摘要： The purpose of this randomized, placebo-controlled, triple-blind trial on 60 healthy female volunteers was to assess the cosmetic effects on skin quality of a food supplement containing special collagen peptides together with acerola extract, vitamin C, vitamin E, biotin, and zinc after an intake of 12 weeks (Elasten(cid:2), QUIRIS Healthcare, Germany). To reduce assessment bias maximally and increase the accuracy and objectivity of the outcomes, the trial design was triple blinded in a manner that neither the subjects nor the person administering the products nor the person who assessed the primary outcomes knew which subjects had received the test product and which had received the placebo. The expert grader assessing the confocal laser scanning microscopy images was additionally blinded regarding the time when the image was taken (on days 1 or 85). The objective, blinded, and validated image analyses using confocal laser scanning microscopy showed a signi?cant improvement of the collagen structure of facial skin (primary endpoint) after intake of the test product, while no improvements were found after intake of the placebo. The proven positive nutritional effect on the collagen structure was fully consistent with positive subjective evaluations of relevant skin parameters such as elasticity, crinkliness/wrinkliness, and evenness in different body areas such as face, hands, de′collete′, neck, backside, legs, and belly, all serving as secondary endpoints. The test product was found to be safe and very well tolerated. A cosmetically relevant improvement of the facial skin was demonstrated after administration of the collagen supplement.
关键词： dermonutrient,antiaging,skin beauty,collagen peptides,dermal collagen structure,oral collagen supplement
更新于2025-09-19 17:13:59
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Fabrication of Sb2Se3 thin film solar cells by co-sputtering of Sb2Se3 and Se targets
摘要： Antimony selenide (Sb2Se3) has attracted scientific interest due to its many advantages such as its appropriate band gap, non-toxicity, element abundance, and high absorption coefficient (> 105 cm?1). However, selenium (Se) is easily lost at high vapor pressures, thus leading to Se vacancies and increased recombination centers in films. In this work, Sb2Se3 films with good crystallinity were fabricated by co-sputtering of Sb2Se3 and Se targets with a substrate temperature of 350 °C and without a subsequent annealing process. The crystal structural properties, surface morphology, and optical and electrical properties of films with different Se contents were explored. Finally, we fabricated solar cells with a structure of FTO/CdS/Sb2Se3/Au and achieved an efficiency up to 3.47%.
关键词： Thin film,Selenium supplement,Co-sputtering,Sb2Se3
更新于2025-09-11 14:15:04