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Retinal vascular density evaluated by optical coherence tomography angiography in macular telangiectasia type 2
摘要： Purpose To evaluate the retinal and choroidal vascular changes through optical coherence tomography angiography (OCTA) in patients with macular telangiectasia type 2 (MacTel 2). Methods Our study included 20 patients (40 eyes) with MacTel 2, and age-matched and sex-matched 18 subjects (36 eyes) in the control group. Fundus color photographs, fundus autofluorescence, fundus fluorescein angiography, spectral-domain optical coherence tomography and OCTA were performed. Foveal vascular density and parafoveal vascular density (PFVD), and foveal retinal thickness and parafoveal retinal thickness, choroidal thickness (CT) and retinal ganglion cell–inner plexiform layer (GCIPL) were compared between MacTel 2 patients and normal age-matched controls. Results The retinal whole vascular density and PFVD of the deep plexus were significantly lower in patients with MacTel 2 than that of the control group (56.93% vs. 58.54%, p = 0.003; and 60.38% vs. 61.66%, p = 0.045). The foveal avascular zone (FAZ) of the deep plexus was significantly enlarged in patients with MacTel 2 than that of the control group (0.44 vs. 0.36, p = 0.009). There was a positive and statistically significant correlation between the FAZ of the superficial and deep plexus and CT in patients with MacTel 2. There was a positive and statistically significant correlation between retinal whole, parafoveal temporal quadrant vascular density of the superficial and deep plexus and GCIPL thickness in patients with MacTel 2. Conclusions Our study demonstrated that important retinal vascular density and FAZ changes in MacTel 2 occur in the deep capillary plexus of the retina.
关键词： Macular telangiectasia type 2,Vascular density,Choroidal thickness,Retinal ganglion cell–inner plexiform layer,Optical coherence tomography angiography
更新于2025-09-23 15:23:52
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Swept source optical coherence tomography analysis of choroidal thickness in macular telangiectasia type 2: a case-control study
摘要： Purpose There has been a recent interest in the association of macular telangiectasia (MacTel) type 2 with central serous choroidopathy and other pachychoroid disorders. This study was performed to assess the subfoveal choroidal thickness (SFCT) in patients with MacTel type 2 and compare it with healthy controls using swept source optical coherence tomography (SS-OCT). Methods It was a retrospective case-control study performed at a tertiary eye care center. The cases constituted patients with MacTel type 2 detected over the last 2 years (April 2016 to March 2018). The controls were healthy adults with no posterior segment pathology. The patients were evaluated with color fundus photography, SS-OCT (Triton, Topcon Inc., Oakland, New Jersey, USA) and fundus fluorescein angiography. The cases were staged based on Gass and Blodi classification. SFCT was compared between the two groups. Results Sixty-five eyes of 33 patients with MacTel were included. The controls consisted of 61 eyes of 33 healthy age-matched (p = 0.81) and sex-matched (p = 0.31) adults. The mean SFCT in cases (353.0 ± 91.2 μm) was higher than controls (289.2 ± 69.0 μm), and this difference was statistically significant (p = 0.0001). The mean SFCT was different in various stages: 346.6 ± 86.3 μm (stage 2), 334.6 ± 90.2 μm (stage 3), 374.6 ± 94.0 μm (stage 4), and 294.8 ± 68.8 μm (stage 5), though this was not statistically significant (p = 0.28). Conclusions The choroid in MacTel type 2 patients was significantly thickened as compared to controls. SFCT may vary as the structural changes worsen over time.
关键词： Macular telangiectasia type 2,Swept source optical coherence tomography,Subfoveal choroidal thickness,Enhanced depth imaging
更新于2025-09-23 15:22:29
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A new technique for the treatment of nasal telangiectasia using atmospheric plasma (voltaic arc dermabrasion): Postoperative pain assessment by thermal infrared imaging
摘要： Background: Nasal telangiectasias are superficial, small vessels in the ala nasi and nasolabial crease with a varying origin. They represent an unaesthetic condition, frustrating patients who frequently request their removal. Microsclerotherapy, electrosurgery, different types of laser therapy, needle-assisted electrocoagulation, and TRASER therapy have been described for treating this condition. Aims: The aim of this study is to describe a novel technique that removes nasal telengectiasias using voltaic arc dermabrasion (VAD). Patients/Methods: Voltaic arc dermabrasion treatment was used to remove nasal telangiectasia in 23 patients. The post-treatment condition was monitored by means of photographic records and the evaluation of erythema, pain score, patient and surgeon satisfaction, and skin temperature. The timing points were 1, 4, 6 days and 1 year after treatment. Results: Patients referred a moderate pain during the treatment that ceased at the end of the procedure. Moderate erythema and punctiform fine crusting were present in all patients that lasted until the 6th day after treatment. No other adverse effects were observed. After 1-year, the mean patient and surgeon satisfaction scores were 2.90 and 3.00 ± 0.3, respectively. A single treatment was effective in 85% of the patients and no recurrences were recorded for one year. The skin temperature increased about 18.2 ± 3.2°C during the treatment but returned to basal values in about 20 seconds in most of the patients. Conclusion: Voltaic arc dermabrasion treatment is a viable, easy to use, and inexpensive tool for successful nasal telangiectasia removal, with minimal post-treatment discomfort.
关键词： nasal telangiectasia,plasma,voltaic arc dermabrasion,atmospheric plasma
更新于2025-09-23 15:21:01
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State of the art on cryo-laser cryo-sclerotherapy in lower limb venous aesthetic treatment
摘要： Here we describe a combination of neodymium:yttrium-aluminium-garnet 1064-nm laser emission and injection of 75% dextrose solution to treat lower limb reticular veins. The strategy is known as cryo-laser cryo-sclerotherapy. Preliminary outcomes are reported, showing ecchymosis in up to 30% of cases and intravenous thrombus in 14%. A satisfactory vessel elimination is found in 86% of cases. No improvement or worsening was reported in 14% of patients. The paper provides technical details with the aim of promoting homogeneity in future data collection, so fostering publication of long-term effectiveness and related comparative evaluation with sclerotherapy and laser treatment alone.
关键词： Cryo-laser,Aesthetic phlebology,Sclerotherapy,CLaCS,Laser,Augmented reality,Cryo-sclerotherapy,Telangiectasia,Reticular veins,Score 9-1,Spider veins
更新于2025-09-23 15:19:57
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A retrospective analysis for facial telangiectasia treatment using pulsed dye laser and intense pulsed light configured with different wavelength bands
摘要： Background: Facial telangiectasia is one of the common skin vascular lesions characterized by dilated cutaneous vasculatures. The variety of diameters and difference in depths of lesional blood vessels are the major challenges for effective treatments for Facial telangiectasia. Aims: To compare the efficacy and safety profiles of pulsed dye laser (PDL, 595 nm) with intense pulsed light (IPL) configured by three different wavelength bands in the treatment for facial telangiectasia in Asian populations. Patients/Methods: A retrospective analysis of hospital records and review on photographs were performed for those subjects with facial telangiectasia (n = 160) who were treated in our department from January 2017 to January 2019. Patients were received two sessions of one of the four following laser treatments: PDL (595 nm, n = 38), IPL with M22 vascular filter (530‐650 nm and 900‐1200 nm, n = 39), M22 560 (560‐1200 nm, n = 42), and M22 590 (590‐1200 nm, n = 41). Results: The patients in all the four groups showed an overall and significant improvement of indexes of lesional severity and subjective discomfort as well as improvement score of facial telangiectasia after treatment as compared to baseline. In addition, PDL (595 nm) and IPL with vascular filter (530‐650 nm and 900‐1200 nm) treatments showed significantly better indexes of lesional severity, subjective discomfort, and improvement score of facial telangiectasia as compared with other two treatments. Conclusion: Light devices with various wavelength ranges showed different efficacies of treatment for facial telangiectasia, among which PDL (595 nm) and IPL with M22 vascular filter (530‐650 nm and 900‐1200 nm) had similar and the best clinical efficacy as compared to IPL with other wavelength bands.
关键词： pulsed dye laser,intense pulse light,facial telangiectasia,efficacy,retrospective analysis
更新于2025-09-19 17:13:59
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Photodynamic Therapy Versus Glucose for the Treatment of Telangiectasia: A Randomised Controlled Study in a Rabbit Ear Model
摘要： This experimental animal study shows that photodynamic therapy (PDT) of telangiectasia signi?cantly reduces the treated vein length and area temperature without causing severe histological damage, such as necrosis or ulceration. These preliminary ?ndings should stimulate further tests using this new approach for the treatment of telangiectasia.
关键词： Hypertonic glucose solution,Photodynamic therapy,Telangiectasia,Rabbit ear model
更新于2025-09-16 10:30:52
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[IEEE 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) - Munich, Germany (2019.6.23-2019.6.27)] 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) - Clinical Study for Assessing the Use of a Compact Vecsel-Based Yellow (590 Nm) Laser System in the Treatment of Vascular Lesions
摘要： The treatment of superficial vascular lesions on skin are among the most common sought-after dermatological laser procedures. The treatment method is based on the absorption of laser light by haemoglobin in blood, which results in the transfer of heat and wanted vessel wall damage. The yellow wavelength range is considered ideal for this purpose, because of the high absorption peak of haemoglobin around 577 nm. However, the yellow spectral range is challenging for any laser technology to produce, which is why there are only a few options on the market, notably the pulsed dye laser (PDL), resulting in limited and expensive treatments. We report on a clinical study that assessed the efficacy of a compact high-power yellow laser system designed for the treatment of cutaneous vascular lesions, such as telangiectasia. The laser system is based on frequency-doubled vertical-external-cavity surface-emitting lasers (VECSELs); a novel technology, which has emerged as an attractive alternative to solid-state, and dye lasers due to the enhanced functionality and broad wavelength coverage [1,2]. The system includes a handheld scanner for an easy and fast delivery of laser light onto skin and is capable of emitting 8 W (continuous wave) at the challenging 590 nm wavelength range (see Fig. 1 Left). The first head-to-head clinical study (ClinicalTrials.gov Identifier: NCT03472859) compared the efficacy of the VECSEL-based yellow laser system and a traditional green KTP laser in the treatment of facial telangiectasia [3]. Altogether 24 subjects participated and completed the clinical study. The subjects were randomized to receive KTP treatment on one side of the face and yellow laser treatment on the other side. Each subject received 1–2 treatments with both lasers. The efficacy of the treatments was assessed by blinded investigators using before and after images taken with a Visia imaging system (see Fig. 1 Right). There was no statistically significant difference between the efficacies of the two lasers; 83% of the subjects had at least 50% improvement after the first treatment with the yellow laser system and similar results were observed for the KTP laser. Treatments with the yellow laser system were 4.7-fold faster than with the KTP but subjects experienced more pain, which limited the use of higher fluences. The yellow laser system settings were 5.6-8.1 J/cm2, whereas as green KTP settings were 20–30 J/cm2. In the next study, we will add a cooling device to the yellow laser to enable the use higher fluences, which is expected to lead to better results, as demonstrated by Kapiciogly et al [4].
关键词： vascular lesions,yellow laser,KTP laser,telangiectasia,VECSEL
更新于2025-09-12 10:27:22