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- 摘要
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Ultrathin Tellurium Oxide/Ammonium Tungsten Bronze Nanoribbon for Multi-Modality Imaging and Second Near-Infrared Region Photothermal Therapy
摘要： Developing nano-photothermal agents (PTAs) with satisfied photothermal conversion efficiency (PTCE) in the second NIR window (1000-1350 nm, NIR II) holds great promise for enhanced photothermal therapy (PTT) effect. Herein, we develop a NIR-II PTA with advanced PTCE, based on a new two-dimensional (2D) ultrathin tellurium oxide/ammonium tungsten bronze (TeO2/(NH4)xWO3) nanoribbons (TONW NRs). The doped ammonia ions mediated-free electrons injection into the LUMO band of WO3 combined with the electronic transitions between W6+ ions and the lone pair of electrons in Te atoms achieve excellent NIR absorption of TONW NRs resulted from localized surface plasmon resonance (LSPR). The polyethylene glycol functionalized TONW NRs (PEG-TONW NRs) exhibit good stability and biocompatibility, displaying a PTCE high to 43.6%, surpassing many previous nano-PTAs active in the NIR II region, leading to remarkable tumor ablation ability both in vitro and in vivo. Meanwhile, advanced X-ray computed tomography (CT) and photoacoustic (PA) imaging capability of PEG-TONW NRs were also realized. Given the admirable photothermal effect in NIR II region, good biocompatibility and advanced CT/PA imaging diagnosis capability, the novel PEG-TONW NRs is promising in future personalized medicine application.
关键词： photothermal therapy,multimodal imaging,tellurium oxide,two-dimensional nanomaterials,ammonium tungsten bronze,the second NIR window
更新于2025-09-23 15:22:29
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Biologically Responsive Plasmonic Assemblies for Second Near-Infrared Window Photoacoustic Imaging-Guided Concurrent Chem-Immunotherapy
摘要： We developed dual biologically responsive nanogapped gold nanoparticle vesicles loaded with immune inhibitor and carried with anticancer polymeric prodrug for synergistic concurrent chemo-immunotherapy against primary and metastatic tumors, along with guided cargo release by photoacoustic (PA) imaging in the second near-infrared (NIR-II) window. The responsive vesicle was prepared by self-assembly of nanogapped gold nanoparticles (AuNNPs) grafted with poly(ethylene glycol) (PEG) and dual pH/GSH-responsive polyprodrug poly(SN38-co-4-vinyl pyridine) (termed as AuNNP@PEG/PSN38VP), showing intense PA signal in the NIR-II window. The effect of the rigidity of hydrophobic polymer PSN38VP on the assembly structures and the formation mechanism of AuNNP@SN38 Ve were elucidated by computational simulations. The immune inhibitor BLZ-945 was encapsulated into the vesicles, resulting in pH-responsive release of BLZ-945 for targeted immunotherapy, followed by the dissociation of the vesicles into single AuNNP@PEG/PSN38VP. The hydrophilic AuNNP@PEG/PSN38VP nanoparticles could penetrate deep into the tumor tissues, and release the anticancer drug SN38 under the reductive environment. PA signal in the NIR-II window in the deep tumor region was obtained. The BLZ-945 loaded vesicle enabled enhanced PA imaging-guided concurrent chemo-immunotherapy efficacy, inhibiting the growth of both primary tumors and metastatic tumors.
关键词： the second NIR window,amphiphilic nanogapped gold nanoparticles,polymeric prodrug,chemo-immunotherapy,photoacoustic imaging
更新于2025-09-23 15:19:57
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Critical Review—Recent Progress in NIR Fluorophores Emitting over 1000 nm for Bioimaging
摘要： During the last five years, significant advances have been made in the synthesis of near-infrared (NIR) fluorophores emitting over 1000 nm for non-invasive deep-tissue imaging. Nano-materials such as single-walled carbon nanotubes (SWCNTs), following Ag2S and PbS quantum dots (QDs) have been employed as the first-generation NIR fluorescent probes, by which superior capabilities of NIR fluorescence imaging at the wavelengths of 1000–1400 nm (second NIR window) have been demonstrated. Recently, from the viewpoint of biomedical applications, organic-dye based NIR fluorophores emitting beyond 1000 nm have been synthesized. In this short review, we focus on recent advances in nanomaterial and organic-dye based NIR fluorophores for intravital deep bioimaging in the second NIR window.
关键词： bioimaging,organic dyes,second NIR window,nanomaterials,NIR fluorophores
更新于2025-09-19 17:15:36