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Comparison of Widefield and Circumpapillary Circle Scans for Detecting Glaucomatous Neuroretinal Thinning on Optical Coherence Tomography
摘要： Purpose: Our purpose was to compare the effectiveness of detecting progressive retinal nerve fiber layer (RNFL) thickness changes using widefield scans compared to circumpapillary circle scans derived from optic disc volume scans when using a manual region-of-interest (ROI) approach. Methods: In a prospective observational study, a total of 125 eyes diagnosed clinically with glaucoma or suspected glaucoma that had both widefield (12 3 9 mm) and optic disc (6 3 6 mm) scans obtained at least one year apart were included. Changes in the RNFL thickness between the two visits were evaluated within region(s) of observed or suspected glaucomatous damage, which were manually outlined after reviewing key features from each scan on the second visit (described as a manual ROI approach). Within ROI(s), changes in the widefield and circumpapillary RNFL thickness (wfRNFLROI and cpRNFLROI), as well as in the global circumpapillary RNFL thickness (cpRNFLG), were determined. The performance of these three methods for detecting progressive changes was compared using longitudinal signal-to-noise ratios (SNRs), whereby the rate of change determined by each method was normalized by individualized estimates of measurement variability and age-related change. Results: On average, the longitudinal SNRs for the wfRNFLROI, cpRNFLROI, and cpRNFLG methods were (cid:2)0.57, (cid:2)0.38, and (cid:2)0.23 y(cid:2)1, respectively, being significantly more negative for the wfRNFLROI than the latter two methods (P (cid:3) 0.009). Conclusions: Progressive RNFL thickness changes were more effectively detected on widefield optical coherence tomography (OCT) scans using a manual ROI approach compared to conventional derived circumpapillary circle scans.
关键词： glaucoma,widefield,optical coherence tomography,progression
更新于2025-09-23 15:22:29
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Nonmydriatic widefield retinal imaging with an automatic white LED confocal imaging system compared with dilated ophthalmoscopy in screening for diabetic retinopathy
摘要： Purpose To compare nonmydriatic montage widefield images with dilated fundus ophthalmoscopy for determining diabetic retinopathy (DR) severity. Materials and methods In this prospective, observational, cross-sectional study, patients with a previous diagnosis of diabetes and without history of diabetes-associated ocular disease were screened for DR. Montage widefield imaging was obtained with a system that combines confocal technology with white-light emitting diode (LED) illumination (DRSplus, Centervue, Padua, Italy). Dilated fundus examination was performed by a retina specialist. Results Thirty-seven eyes (20 patients, 8 females) were finally included in the analysis. Mean age of the patients enrolled was 58.0 ± 11.6?years [range 31–80?years]. The level of DR identified on montage widefield images agreed exactly with indirect ophthalmoscopy in 97.3% (36) of eyes and was within 1 step in 100% (37) of eyes. Cohen’s kappa coefficient (κ) was 0.96, this suggesting an almost perfect agreement between the two modalities in DR screening. Nonmydriatic montage widefield imaging acquisition time was significantly shorter than that of dilated clinical examination (p = 0.010). Conclusion Nonmydriatic montage widefield images were compared favorably with dilated fundus examination in defining DR severity; however, they are acquired more rapidly.
关键词： Diabetic retinopathy,Screening,Widefield retinal imaging
更新于2025-09-23 15:21:01
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Ultra-Widefield Laser Scanning Retina Imaging in Oculocutaneous Albinism
摘要： A 5-year-old girl with abnormalities of the skin and hair that were consistent with albinism had nystagmus and photophobia. Her skin color varied from yellow to milky white and hypopigmentation was appreciated by comparison with other family members. She received ultra-widefield laser scanning imaging (Daytona P200T; Optos) to observe the pigment of the fundus to make a definitive diagnosis of oculocutaneous albinism. The vortex veins and a hypoplasia of the macula were noted (Figure). Oculocutaneous albinism is characterized by photophobia, nystagmus, fundus hypopigmentation, and the absence of foveal pit.
关键词： Ultra-Widefield Laser Scanning Retina Imaging,Oculocutaneous Albinism,Ophthalmic Images
更新于2025-09-19 17:13:59
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Characteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopy
摘要： PURPOSE. To investigate fundus autofluorescence (FAF) and other fundus manifestations in congenital aniridia. METHODS. Fourteen patients with congenital aniridia and 14 age- and sex-matched healthy controls were examined. FAF images were obtained with an ultra-widefield scanning laser ophthalmoscope. FAF intensity was quantified in the macular fovea and in a macular ring surrounding fovea and related to an internal reference within each image. All aniridia patients underwent an ophthalmologic examination, including optical coherence tomography and slit-lamp biomicroscopy. RESULTS. Mean age was 28.4 6 15.0 years in both the aniridia and control groups. Fovea could be defined by subjective assessment of FAF images in three aniridia patients (21.4%) and in all controls (P ? 0.001). Mean ratio between FAF intensity in the macular ring and fovea was 1.01 6 0.15 in aniridia versus 1.18 6 0.09 in controls (P ? 0.034). In aniridia, presence of foveal hypoplasia evaluated by biomicroscopy correlated with lack of foveal appearance by subjective analyses of FAF images (P ? 0.031) and observation of nystagmus (P ? 0.009). CONCLUSIONS. Aniridia patients present a lower ratio between FAF intensity in the peripheral and central macula than do healthy individuals. Both subjective and objective analyses of FAF images are useful tools in evaluation of foveal hypoplasia in aniridia.
关键词： optical coherence tomography,widefield imaging,fundus autofluorescence,aniridia,macular hypoplasia
更新于2025-09-16 10:30:52