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Chitosan-based hydrogels prepared by UV polymerization for wound dressing
摘要： Chitosan-based hydrogels were prepared by grafting with poly(acrylic acid) (PAA) and poly(hydroxyethyl methacrylate) (pHEMA) through ultraviolet polymerization to further improve its hydrophilic nature and enhance its mechanical properties. The epidermal growth factor (EGF) was incorporated inside the hydrogels to stimulate the wound healing. The physical characterization of chitosan-PAA-pHEMA hydrogel indicates that it is highly hydrophilic with adequate properties for wound dressing purpose. The biological characterization shows that chitosan-based hydrogel retains its thrombogenic and antibacterial properties. The in vivo wound healing experiment demonstrates that the hydrogel-incorporated EGF has better wound healing rate than other dressings.
关键词： hydrogel,Chitosan,2-hydroxyethyl methacrylate,epidermal growth factor,wound dressing,acrylic acid
更新于2025-09-23 15:22:29
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Aloe-Emodin/Carbon Nanoparticles Hybrid Gels with Light-Induced and Long-Term Antibacterial Activity
摘要： Development of effective antimicrobial wound dressings has drawn wide attention in the wound care market. Here, we synthesized a natural antibiotic (aloe-emodin, AE) and carbon nanoparticles co-embedded polymer hybrid hydrogel as a novel wound dressing in the fight against skin infections potently. We systematically evaluated the properties of the obtained hydrogels, including physic-chemical characteristics, photothermal conversion efficiency, reactive oxygen species (ROS) generation, AE-released profile, antibacterial activity and wound-healing capability. The hybrid gels can initially deduct the number of bacteria rapidly in a short time through the near-infrared-light (NIR)-triggered photothermal/ROS route, and continuously kill the remaining live cells by released-AE from gels after turning off NIR source with the long-term antibacterial effect. These two antibacterial manners that complement each other lead to the excellent antibacterial performances towards various bacterial strains including multidrug-resistant bacteria. Moreover, in vivo Staphylcoccus aureus-infected animal experiments indicate that the hybrid gels upon NIR irradiation have a striking ability towards wound infection. These studies demonstrate that the AE and carbon nanoparticles co-embedded hybrid polymer hydrogels with NIR exposure may have applications in the wound combined care for bacterial infections.
关键词： NIR irradiation,aloe-emodin,wound dressing,ROS,carbon nanoparticles,antibacterial hydrogel
更新于2025-09-23 15:21:21