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Porous Organic Polymer-Coated Band-Aids for Phototherapy of Bacteria-Induced Wound Infection
摘要： Band-Aids have been widely used for wound care. For most adhesive bandages, however, they have limited capacity to speed up the wound healing process, which in turn may cause serious wound infections. In this study, antibacterial Band-Aids, combining porphyrin based porous organic polymers (POPs) with commercial antibiotics-free Band-Aids, are designed. Under white light irradiation, POP can produce effective photothermal heat, as well as highly reactive oxygen species (ROS), thereby triggering the potent hyperthermia and simultaneous ROS increase on wounds. What's more, white-light is similar with sunlight, which makes POP-based Band-Aids (PBA) ideal wound dressings for wound disinfection.
关键词： wound infection,porous organic polymers,band-aids,white light
更新于2025-09-23 15:23:52
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Evaluation of photodynamic therapy effect along with colistin on pandrug-resistant <i>Acinetobacter baumannii</i>
摘要： Background and Aims: Pandrug-resistant Acinetobacter baumannii (PDRAB) are including colistin resistant starins (CoRAB) which cause infections potentially untreatable infections. Recently, incidence of these strains are increasing worldwide. Therefore, new approaches, methods and strategies are urgently needed for treatment and eradication of infections due to PDRAB. So the aim of this study was to evaluate the efficacy of photodynamic therapy (PDT) in combination treatment with colistin against PDRAB. Materials and Methods: PDRAB which was isolated from burn patients was used as a test strain. PDT carried out in which toluidine blue O (TBO) and light-emitting diode (LED) were used as photosensitizer and radiation source, respectively. Then, the effect of PDT plus colistin was evaluated on CoRAB and the colony-forming units of each tested groups calculated. Finally, confirmation of antibacterial activity of combination therapy was carried out using scanning electron microscope. Results: PDT declined bacterial count in comparing with control group by 83.7% of killing percentage, in other words, less than one log reduction. While PDT in combination with colistin showed high synergetic effect against A. baumannii in all concentrations of colistin tested by 100% of killing percentage with 9-log reduction. Conclusions: According to our results, PDT alone couldn’t eliminate all of the treated bacterial cells. But when combined with colistin, it killed all of the treated bacterial cells in all tested concentrations. Also PDT decreased the minimal inhibitory concentration of colistin against PDRAB by more than 11 fold.
关键词： colistin,Acinetobacter baumannii,wound infection,toluidine blue O,photodynamic therapy,pandrug resistance
更新于2025-09-23 15:21:21