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Efficacy of 577 nm pro-yellow laser in the treatment of melasma: a prospective split-face study
摘要： We aimed to study the effectiveness of 577 nm pro-yellow laser in the treatment of melasma. A total of 82 patients with melasma were included in this comparative study. A detailed medical history, examination, and calculation of Melasma Area and Severity Index were done for all patients. All participants were treated with topical sunscreen and hydroquinone 4% cream on both sides of the face. In addition, the left side of the face was subjected to a single pass of 577-nm pro-yellow laser at a monthly interval for three sessions. Follow up was done by comparing the Melasma area and severity index at 0, 3 and 6 months. At baseline, there is no significant difference in the Melasma area and severity index score between both sides of the face. At 3 months, MASI score was statistically significantly decreased on both sides of the face compared to pretreatment (P < .05). At 6 months, the mean MASI score at the laser-treated side was statistically significantly decreased compared to the non-laser-treated side (P < .05). we concluded that the addition of 577 nm pro-yellow laser in the treatment of melasma leads to maintain the improvement and reduction of the recurrence rate.
关键词： Melasma,hydroquinone cream,pro-yellow laser
更新于2025-09-23 15:21:01
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The Role of Subthreshold Micropulse Yellow Laser as an Alternative Option for the Treatment of Refractory Postoperative Cystoid Macular Edema
摘要： Background: To evaluate the efficacy and the safety of subthreshold micropulse yellow laser (SMYL) in the treatment of chronic postoperative cystoid macular edema (PCME), which is refractory to standard therapies. Methods: A retrospective chart review of ten eyes of ten patients affected by refractory PCME who underwent SMYL was performed. Five PCME cases were subsequent to uncomplicated cataract surgery (CS), two cases to complicated CS (CCS) with posterior capsule rupture and three cases occurred after retinal detachment surgery (RD). All conditions were refractory to conventional treatments prior to SMYL interventions for at least 4 months, including nonsteroidal anti-inflammatory eyedrops, topical steroids, oral indomethacin, sub-Tenon’s triamcinolone injections and Dexamethasone intravitreal implants. All patients underwent one or more treatments with 577 nm SMYL photo-stimulation, with 7 × 7 grids with confluent spots and a 5% duty cycle covering the whole edematous retina, including the foveal center. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were obtained using OCT, and evaluated before and after the treatment at 1, 2, 3 and 6-month follow-ups. Results: A complete subfoveal macular edema resolution was observed in all of the eyes, with statistically significant improvements in terms of BCVA and CMT in all of the follow-up timelines (at 6 months, p = 0.002 and p = 0.005, respectively). The mean number of laser treatments was 1.3. At the final follow-up, a complete subfoveal edema reabsorption was observed in all patients with visual acuity improvement. No complications were observed in any case. Conclusions: SMYL seems to be a safe and effective treatment for the long-term resolution of refractory PCME and may be a useful alternative to expensive and invasive therapeutic options.
关键词： micropulse yellow laser,cataract surgery,refractory macular edema,post-surgical cystoid macular edema
更新于2025-09-23 15:19:57
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[IEEE 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) - Munich, Germany (2019.6.23-2019.6.27)] 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) - Clinical Study for Assessing the Use of a Compact Vecsel-Based Yellow (590 Nm) Laser System in the Treatment of Vascular Lesions
摘要： The treatment of superficial vascular lesions on skin are among the most common sought-after dermatological laser procedures. The treatment method is based on the absorption of laser light by haemoglobin in blood, which results in the transfer of heat and wanted vessel wall damage. The yellow wavelength range is considered ideal for this purpose, because of the high absorption peak of haemoglobin around 577 nm. However, the yellow spectral range is challenging for any laser technology to produce, which is why there are only a few options on the market, notably the pulsed dye laser (PDL), resulting in limited and expensive treatments. We report on a clinical study that assessed the efficacy of a compact high-power yellow laser system designed for the treatment of cutaneous vascular lesions, such as telangiectasia. The laser system is based on frequency-doubled vertical-external-cavity surface-emitting lasers (VECSELs); a novel technology, which has emerged as an attractive alternative to solid-state, and dye lasers due to the enhanced functionality and broad wavelength coverage [1,2]. The system includes a handheld scanner for an easy and fast delivery of laser light onto skin and is capable of emitting 8 W (continuous wave) at the challenging 590 nm wavelength range (see Fig. 1 Left). The first head-to-head clinical study (ClinicalTrials.gov Identifier: NCT03472859) compared the efficacy of the VECSEL-based yellow laser system and a traditional green KTP laser in the treatment of facial telangiectasia [3]. Altogether 24 subjects participated and completed the clinical study. The subjects were randomized to receive KTP treatment on one side of the face and yellow laser treatment on the other side. Each subject received 1–2 treatments with both lasers. The efficacy of the treatments was assessed by blinded investigators using before and after images taken with a Visia imaging system (see Fig. 1 Right). There was no statistically significant difference between the efficacies of the two lasers; 83% of the subjects had at least 50% improvement after the first treatment with the yellow laser system and similar results were observed for the KTP laser. Treatments with the yellow laser system were 4.7-fold faster than with the KTP but subjects experienced more pain, which limited the use of higher fluences. The yellow laser system settings were 5.6-8.1 J/cm2, whereas as green KTP settings were 20–30 J/cm2. In the next study, we will add a cooling device to the yellow laser to enable the use higher fluences, which is expected to lead to better results, as demonstrated by Kapiciogly et al [4].
关键词： vascular lesions,yellow laser,KTP laser,telangiectasia,VECSEL
更新于2025-09-12 10:27:22
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Efficacy of 577‐nm Pro‐Yellow laser in port wine stain treatment
摘要： A port-wine stain (PWS) is a congenital capillary malformation that is seen in 0.3–0.5% of newborns. Although many types of lasers have been used to treat PWSs, few studies have investigated the efficacy of 577-nm Pro-Yellow lasers. The aim of this study was to establish the efficacy of Pro-Yellow lasers in PWS treatment. In total, 26 patients, comprising 15 females (57.7%) and 11 males (42.3%) with a mean age of 24.7 ± 11.8 (range 1–50) years were included in the study. All were treated with a 577-nm Pro-Yellow laser at 4-week intervals, 3–10 times. The sessions initially used scan mode and a fluence dose of 24 J/cm2 per session, on average. The mean dose was increased by 4 J/cm each session and the maximum dose administered was 44 J/cm2. A mean regression of 68.8 ± 13.9% in the size of the lesions over 5.23 ± 2.7 sessions was observed. There was no statistically significant difference between the female and male patients when they were compared in terms of the number of treatment sessions (p = .789) and treatment success (p = .39). These case series demonstrate that the Pro-Yellow laser is a safe and well-tolerated treatment for PWSs. However, deep-seated lesions required more treatment sessions and it was observed that clinically the lesions did not completely disappear.
关键词： Pro Yellow laser,577 nm laser,laser treatment,port-wine stain
更新于2025-09-11 14:15:04
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[IEEE 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) - Munich, Germany (2019.6.23-2019.6.27)] 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) - High Power, Ultrafast Yellow Laser using Fourth-Harmonic Generation of Ultrafast Mid-IR Cr <sup>2+</sup> :ZnS Laser in MgO:PPLN Crystal
摘要： The ultrafast optical radiation in the yellow spectral region is of great interest for variety of scientific and technological applications including astronomy, spectroscopy and medicine, with potential to revolutionize eye surgeries through exquisite accuracy [1, 2]. However, it is relatively difficult to access the yellow region, especially when good beam quality, high power and high efficiency are required. Till date, various types of yellow lasers have been reported [3, 4] mostly in CW regime and nanosecond timescales. Here, we report on a compact, high- power, high repetition-rate, ultrafast source of yellow radiation. Using an ultrafast Cr2+:ZnS laser of average power of 4.5 W with spectral width of Δλ=138 nm centered at 2.36 μm, producing output pulses of width ~40 fs at a repetition rate of 80 MHz, and two stage single-pass second harmonic generation (SHG), we have generated ultrafast radiation of power 1 W tunable across 577-589 nm. The schematic of the experimental setup is shown in Fig. 1(a). The single-pass SHG of Cr2+:ZnS laser in a 2 mm long 5% mol doped MgO:PPLN multi-grating crystal (Λ=33.15 - 35.25 μm), giving second harmonic (SH) pulses of 90 fs at 1.18 μm, with a maximum average power of 2.3 W at a single-pass efficiency as high as 65%. Further the 1.18 μm radiation is frequency-doubled in a 1 mm long and 0.5×1 mm2 in aperture, MgO:PPLN crystal (Λ=8.9 -9.45 μm) producing yellow radiation. The acceptance bandwidth (FWHM) and temporal walk-off length (LT) of the second crystal are calculated to be 3 nm and 288 μm, respectively. In order to optimize the focusing condition for maximum fourth harmonic generation (FHG) efficiency, we pumped the crystal at constant power of 1.3 W at 1.18 μm and recorded the fourth harmonic (FH) power as a function of focusing parameter, ξ =L/b, where, L is the length of the crystal and b=2πnw0 2/λ, w0 is the beam waist radius, n is the refractive index of the crystal and λ is the input wavelength.
关键词： Cr2+:ZnS laser,MgO:PPLN crystal,fourth-harmonic generation,ultrafast yellow laser
更新于2025-09-11 14:15:04