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POSS: A Morphology-Tuning Strategy to Improve the Sensitivity and Responsiveness of Dissolved Oxygen Sensor
摘要： Dissolved oxygen (DO) plays a crucial role in environment, food processing, and biotechnology. Although several physical-doping DO probes have been developed, a sensitive and reliable sensor for real-time and non-invasive DO detection in bioprocess is still challenging. Here we demonstrate a morphology-tuning strategy to improve the sensitivity and responsiveness of DO polymeric sensors (P(Pt-TPP-TFE-Ad) and P(Pt-TPP-TFE-POSS)) by decorating with the same platinum(II) porphyrins and different morphology-tunable moieties in supporting matrix. Experimental results manifest the sensitivity and response of sensors increase with size effect of the morphology-tunable moiety in due that the bulky morphology-tunable moiety facilitates the formation of interconnected and porous network that can promote oxygen permeability. Additionally, P(Pt-TPP-TFE-POSS) features excellent linear Stern-Volmer quenching, superior stability, and reversible response, thereby permitting the real-time and non-invasive quantification of DO during cephalosporin C fermentation. Our work offers an ideal tool for online sensing of DO in industrial and biological applications.
关键词： porphyrin,sensors,biofermentation,morphology-tuning,dissolved oxygen
更新于2025-11-19 16:56:35
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Cavitation inception pressure and bubble cloud formation due to the backscattering of high-intensity focused ultrasound from a laser-induced bubble
摘要： Cavitation bubble cloud formation due to the backscattering of high-intensity focused ultrasound (HIFU) from a laser-induced bubble in various water temperatures and dissolved oxygen (DO) has been investigated. A laser-induced bubble generated near the geometrical focus of HIFU is utilized to yield intense negative pressure by the backscattering. Optical observation with a high-speed video camera and pressure measurement with a fiber-optic probe hydrophone are conducted simultaneously to understand the forming process of a bubble cloud and corresponding pressure field by the backscattering. Optical observation shows that a bubble cloud grows stepwise forming multiple layers composed of tiny cavitation bubbles, and the cavitation inception position is consistent with the local minimum pressure position simulated with the ghost fluid method. The bubble cloud grows larger in the opposite direction of HIFU propagation, and the absolute value of the cavitation inception pressure decreases with an increase in water temperature. The linear correlation between cavitation inception pressure and water temperature agrees with that given by Vlaisavljevich, Xu, Maxwell, Mancia, Zhang, Lin, Duryea, Sukovich, Hall, Johnsen, and Cain [IEEE Trans. Ultrason. Ferroelectr. Freq. Control 63, 1064–1077 (2016)]. However DO has minor dependence on the cavitation inception pressure when DO is degassed sufficiently. Furthermore, the gas nucleus size that might exist in the experiment has been estimated by using bubble dynamics.
关键词： Dissolved oxygen,Water temperature,Bubble cloud formation,Cavitation inception pressure,Laser-induced bubble,High-intensity focused ultrasound,Cavitation
更新于2025-09-23 15:19:57
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AIP Conference Proceedings [AIP Publishing 15th International Conference on Concentrator Photovoltaic Systems (CPV-15) - Fes, Morocco (25–27 March 2019)] 15th International Conference on Concentrator Photovoltaic Systems (CPV-15) - Evaluation of dissolved oxygen concentration in silicon wafers by measuring infrared attenuated total reflection
摘要： Dissolved oxygen concentration of silicon wafers were evaluated by measuring infrared absorption of dissolved oxygen in attenuated total reflection (ATR) spectra of silicon wafers and compared with transmission-based evaluation. ATR peak height and the correlation between ATR and transmission was significantly stronger after chemical-mechanical polishing of both sides of wafers to 450 ± 10 μm. The results also indicate that the quantitative evaluation of the oxygen concentration of thin silicon wafers can be done by ATR measurements with appropriate preprocessing.
关键词： dissolved oxygen,infrared attenuated total reflection,ATR,silicon wafers,transmission-based evaluation
更新于2025-09-11 14:15:04
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Amphiphilic Fluorine-Containing Block Copolymers as Carriers for Hydrophobic PtTFPP for Dissolved Oxygen Sensing, Cell Respiration Monitoring and In Vivo Hypoxia Imaging with High Quantum Efficiency and Long Lifetime
摘要： New amphiphilic star or multi-arm block copolymers with different structures were synthesized for enabling the use of hydrophobic oxygen probe of platinum (II)-tetrakis (pentafluorophenyl) porphyrin (PtTFPP) for bioanalysis. The amphiphilic star polymers were prepared through the Atom Transfer Radical Polymerization (ATRP) method by using hydrophilic 4-arm polyethylene glycol (4-arm-PEG) as an initiator. Among the five block copolymers, P1 series (P1a, P1b, and P1c) and P3 possess fluorine-containing moieties to improve the oxygen sensitivity with its excellent capacity to dissolve and carry oxygen. A polymer P2 without fluorine units was also synthesized for comparison. The structure-property relationship was investigated. Under nitrogen atmosphere, high quantum efficiency of PtTFPP in fluorine-containing micelles could reach to 22% and long lifetime could reach to 76 μs. One kind of representative PtTFPP-containing micelles was used to detect the respiration of Escherichia coli (E. coli) JM109 and macrophage cell J774A.1 by a high throughput plate reader. In vivo hypoxic imaging of tumor-bearing mice was also achieved successfully. This study demonstrated that using well-designed fluoropolymers to load PtTFPP could achieve high oxygen sensing properties, and long lifetime, showing the great capability for further in vivo sensing and imaging.
关键词： fluoropolymers,tumor imaging,cell respiration monitoring,dissolved oxygen sensors,micelles
更新于2025-09-10 09:29:36