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Feasibility of a simplified narrow-band imaging classification system for Barrett’s esophagus for novice endoscopists
摘要： Background Narrow-band imaging (NBI) classifications for Barrett’s esophagus have been proposed for the detection of early esophageal adenocarcinoma. We developed a simplified classification system with demonstrated high diagnostic accuracy and reproducibility among experienced endoscopists, but the feasibility of this system among novice endoscopists was unclear. Methods In the present study, eight novice endoscopists with no experience of magnification endoscopy were asked to review 248 images of Barrett’s esophagus (72 dysplastic, 176 non-dysplastic) obtained using high-definition magnification endoscopy with NBI 6 weeks before (1st test), immediately after (2nd test), and 6 weeks after (3rd test) being taught the simplified classification system. The primary outcomes were differences in diagnostic accuracy for dysplasia among the three tests. Results The specificity and overall accuracy improved significantly in the 2nd vs. 1st test [97% vs. 80% (p < 0.001) and 94% vs. 82% (p < 0.001), respectively], sensitivity was comparable (87% in both tests; p = 0.42). In the 3rd test, the sensitivity and overall accuracy decreased significantly compared with the 2nd test [82% vs. 87% (p < 0.001) and 93% vs. 94% (p < 0.05), respectively], but there was no significant difference in specificity (97% in both tests; p = 0.16). The kappa values for interobserver agreement for the mucosal pattern, vascular pattern, and predicted histology were substantial, and improved significantly in the 2nd vs. 1st test (0.78 vs. 0.59, 0.70 vs. 0.53, and 0.79 vs. 0.66, respectively; p < 0.001 for all). Conclusions The simplified NBI classification system may be appropriate for novice endoscopists to use in providing high accuracy and reproducibility.
关键词： Narrow-band imaging,Magnification endoscopy,Barrett’s esophagus,Classification,Esophageal adenocarcinoma
更新于2025-09-23 15:23:52
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Blue-light imaging has an additional value to white-light endoscopy in visualization of early Barrett's neoplasia: an international multicenter cohort study
摘要： Endoscopic features of early neoplasia in Barrett’s esophagus (BE) are subtle. Blue-light imaging (BLI) may improve visualization of neoplastic lesions. The aim of this study was to evaluate BLI in visualization of Barrett’s neoplasia. Methods: Corresponding white-light endoscopy (WLE) and BLI images of 40 BE lesions were obtained prospectively and assessed by 6 international experts in 3 assessments. Each assessment consisted of overview and magnification images. Assessments were as follows: assessment 1, WLE only; assessment 2, BLI only; and assessment 3, corresponding WLE and BLI images. Outcome parameters were as follows: (1) appreciation of macroscopic appearance and surface relief (visual analog scale scores); (2) ability to delineate lesions (visual analog scale scores); (3) preferred technique for delineation (ordinal scores); and (4) quantitative agreement on delineations (AND/OR scores). Results: Experts appreciated BLI significantly better than WLE for visualization of macroscopic appearance (median 8.0 vs 7.0, P < .001) and surface relief (8.0 vs 6.0, P < .001). For both overview and magnification images, experts appreciated BLI significantly better than WLE for ability to delineate lesions (8.0 vs 6.0, P < .001 and 8.0 vs 5.0, P < .001). There was no overall significant difference in AND/OR scores of WLE + BLI when compared with WLE, yet agreement increased significantly with WLE + BLI for cases with a low baseline AND/OR score on WLE, both in overview (mean difference, 0.15; P = .015) and magnification (mean difference, 0.10; P = .01). Conclusions: BLI has additional value for visualization of BE neoplasia. Experts appreciated BLI better than WLE for visualization and delineation of BE neoplasia. Quantitative agreement increased significantly when BLI was offered next to WLE for lesions that were hard to delineate with WLE alone.
关键词： neoplasia,white-light endoscopy,visualization,Barrett's esophagus,delineation,blue-light imaging
更新于2025-09-23 15:23:52
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Detection of Pre-Malignant Gastrointestinal Lesions Using Surface-Enhanced Resonance Raman Scattering-Nanoparticle Endoscopy
摘要： Cancers of the gastrointestinal (GI) tract are among the most frequent and most lethal cancers worldwide. An important reason for this high mortality is that early disease is typically asymptomatic, and patients often present with advanced, incurable disease. Even in high-risk patients who routinely undergo endoscopic screening, lesions can be missed due to their small size or subtle appearance. Thus, current imaging approaches lack the sensitivity and specificity to accurately detect incipient GI tract cancers. Here we report our finding that a single dose of a high-sensitivity surface-enhanced resonance Raman scattering nanoparticle (SERRS-NP) enables reliable detection of pre-cancerous GI lesions in animal models that closely mimic disease development in humans. Some of these animal models have not been used previously to evaluate imaging probes for early cancer detection. The studies were performed using a commercial Raman imaging system, a newly-developed mouse Raman endoscope, and finally a clinically applicable Raman endoscope for larger animal studies. We show that this SERRS-NP-based approach enables robust detection of small, pre-malignant lesions in animal models that faithfully recapitulate human esophageal, gastric, and colorectal tumorigenesis. This method holds promise for much earlier detection of GI cancers than currently possible and could lead therefore to marked reduction of morbidity and mortality of these tumor types.
关键词： cancer,Raman,endoscopy,preclinical,early detection,nanoparticle
更新于2025-09-23 15:23:52
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[IEEE 2018 Wave Electronics and its Application in Information and Telecommunication Systems (WECONF) - Saint-Petersburg, Russia (2018.11.26-2018.11.30)] 2018 Wave Electronics and its Application in Information and Telecommunication Systems (WECONF) - Temperature Measurement Using Endoscopic Acousto-Optical Spectral Imaging System
摘要： The problem of measuring spatial temperature distribution over the surface of hard-to-reach objects with a non-uniform emissivity distribution is considered. We propose to solve it using acousto-optical spectral imaging system. This approach enables precise non-contact temperature measurements as well as contrast visualization in arbitrary narrow spectral bands. The temperature measurement of filament lamp using rigid borescope and acousto-optic imaging filter is presented.
关键词： endoscopy,non-destructive testing,spectral imaging,temperature measurement,acousto-optical tunable filter
更新于2025-09-23 15:22:29
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Face-to-face versus online training for the interpretation of findings in the fiberoptic endoscopic exam of the swallow procedure
摘要： Objective: The aim of this study was to evaluate the comparative effectiveness of an online, interdisciplinary, interactive course designed to increase the ability to accurately interpret the fiberoptic endoscopic exam of the swallow (FEES) procedure to traditional, face-to-face (F2F) lectures for both graduate medical education (GME) and graduate speech language pathology (GSLP) programs. Design: This was a prospective, quantitative, nonrandomized study. Participants were medical residents in physical medicine and rehabilitation from two affiliated programs and graduate students in speech language pathology from two instructional cohorts at a single institution. Group 1, traditional group (n=51), participated in F2F lectures using an audience response system, whereas Group 2, online group (n=57), participated in an online, interactive course. The main outcome measure was pre- and post-course FEES knowledge test scores. Results: For Group 1, the mean pre-course score was 26.94 (SD=3.24) and the post-course score was 34.96 (SD=2.51). Differences between pre- and post-course scores for Group 1 were significant (t=?16.38, P≤0.0001). For Group 2, the mean pre-course score was 27.05 (SD=2.74) and the post-course score was 34.05 (SD=2.84). Differences between pre- and post-course scores for Group 2 were significant (t=?13.5, P≤0.0001). The mean knowledge change score for Group 1 and Group 2 was 8.01 (SD=3.50) and 7.04 (SD=3.91), respectively (nonsignificant, t=1.372, P=0.173), suggesting groups made similar gains. Conclusion: Incorporating technology into GME and GSLP programs yielded comparable gains to traditional lectures. Findings support the use of online education as a viable alternative to the traditional F2F classroom format for the instruction of the cognitive component of the FEES procedure.
关键词： deglutition,training,endoscopy,dysphagia,swallowing,medical education
更新于2025-09-23 15:22:29
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Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models
摘要： Detecting deep tumors inside living subject is still challenging for Cerenkov luminescence imaging (CLI). In this study, a high-sensitivity endoscopic CLI (ECLI) system was developed with a dual-mode deep cooling approach to improve the imaging sensitivity. System was characterized through a series of ex vivo studies. Furthermore, subcutaneous and orthotropic human hepatocellular carcinoma (HCC) mouse models were established for ECLI guided tumor resection in vivo. The results showed that the ECLI system had spatial resolution (62.5 μm) and imaging sensitivity (6.29×10-2 kBq/μl 18F-FDG). While the results from both subcutaneous and orthotropic HCC mouse models demonstrate the effectiveness of the system to intraoperatively guide the surgery of deep tumors such as liver cancer. Overall, the developed system exhibits promising potential for the applications of tumor precise resection and novel nanoprobe based optical imaging.
关键词： Endoscopy,Image-guided surgery,Hepatocellular carcinoma (HCC),Cerenkov luminescence imaging
更新于2025-09-23 15:22:29
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[IEEE 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS) - Cleveland, OH, USA (2018.10.17-2018.10.19)] 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS) - Image Enhancement Method Based on Adaptive Fraction Gamma Transformation and Color Restoration for Wireless Capsule Endoscopy
摘要： Wireless capsule endoscopy (WCE) plays an important role in gastrointestinal (GI) tract observation and disease diagnosis. However, due to the limited illumination and complex environment in GI tract, endoscopic images are usually not clear enough to be interpreted by doctors or used for further processing. Although many algorithms have been proposed to improve image quality from different aspects, the balance of algorithm complexity and image quality is still a challenge worth exploring. In this paper, we propose a novel function named adaptive fraction gamma transformation (AFGT) to enhance the quality of images captured by the WCE. Characteristics of AFGT are adaptive to different luminance in an image and self-tunable to the statistical characteristics of different images. Besides, HSI color space is adopted for color restoration, namely, the saturation component is linearly scaled according to the enhanced intensity component. Experimental results show that performances of the proposed method in both visual quality and objective assessments are better than that of the state-of-art methods.
关键词： wireless capsule endoscopy,color restoration,fraction gamma transformation,image enhancement
更新于2025-09-23 15:22:29
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AIP Conference Proceedings [AIP Publishing LLC PROGRESS IN APPLIED MATHEMATICS IN SCIENCE AND ENGINEERING PROCEEDINGS - Bali, Indonesia (29 September–1 October 2015)] - Reflectance imaging by fiber bundle endoscope: Vertical reconstruction by multipositional illumination
摘要： Fiber bundles for imaging internal organs with minimum physical damage have been increasingly developed for both basic life sciences and clinical applications. Reflectance imaging is possible using fiber bundles for detecting the intrinsic optical contrast of blood vessels and tissue structure. The placement of an illumination source adjacent to imaging optics causes scattered light from deeper tissue layers to illuminate superficial tissues and results in a reflectance image. However, it does not have focal capacity and lacks depth resolution. In this study, we performed spatial analysis for the vertical reconstruction of in vivo tissues using a multipositional illumination scheme. The observed image corresponded to the “shadow” of a target object. When we manipulated the location of illumination, the shadow moved horizontally depending on the depth of the target. We used this horizontal displacement as a cue and successfully performed the vertical reconstruction of mouse brain blood vessels.
关键词： Fiber optics,Reflectance imaging,Endoscopy
更新于2025-09-23 15:21:21
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Feasibility of using an led-probe in third-space endoscopy: a clinical study
摘要： Background: Third-space endoscopy is a novel, safe, and effective method for treating different gastrointestinal conditions. However, several failed endoscopic procedures are attributed to incomplete myotomy. Lighting devices are used to prevent organic injuries. We aimed to investigate the feasibility of using a hand-made LED-probe (LP) in third-space procedures. Methods: This prospective study was conducted in a tertiary-care center in Mexico between December 2016 and January 2019. We included peroral endoscopic myotomy (POEM) and gastric peroral endoscopic myotomy(G-POEM) procedures. Pseudoachalasia, peptic ulcer, normal gastric emptying scintigraphy (GES) and prepyloric tumors were excluded. LP was used to guide or confirm procedures. Clinical and procedural characteristics were recorded and analyzed. Results: Seventy third-space procedures were included (42POEM,28G-POEM), with an average patient age of 46.7 ± 14.3 and 43.7 ± 10.1 years, respectively. For the POEM and G-POEM groups, respectively, 18/42(42.9%) and 13/28(46.7%) patients were males; median procedure times were 50 (interquartile range [IQR]: 38–71) and 60(IQR: 48–77) min, median LP placement times were 5(IQR: 4-6) and 6(IQR: 5-7) min, mild adverse events occurred in 4(9.4%) and 4(14.2%) of cases, and clinical success at 6 months occurred in 100 and 85.7% of cases. Integrated relaxation pressure (IRP) improved from 27.3 ± 10.8 to 9.5 ± 4.1 mmHg (p < 0.001); retention percentage at 4 h also improved. LP was successfully placed and adequate myotomy confirmed including 14.2 and 17.8% of POEM and G-POEM difficult patients. Conclusions: Using an LP is promising and allows guiding during third-space procedures either for submucosal tunnel creation or myotomy confirmation, with excellent safety and efficacy in clinical practice.
关键词： LED-probe,Third-space endoscopy,Gastric peroral endoscopic myotomy,Peroral endoscopic myotomy
更新于2025-09-23 15:21:01
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[Advances in Intelligent Systems and Computing] Image Processing and Communications Challenges 10 Volume 892 (10th International Conference, IP&C’2018 Bydgoszcz, Poland, November 2018, Proceedings) || Video Processing and Analysis for Endoscopy-Based Internal Pipeline Inspection
摘要： Because of the increasing requirements in regards to the pipeline transport regulations, the operators take care to the rigorous application of checking routines that ensure nonoccurrence of leaks and failures. In situ pipe inspection systems such as endoscopy, remains a reliable mean to diagnose possible abnormalities in the interior of a pipe such as corrosion. Through digital video processing, the acquired videos and images are analyzed and interpreted to detect the damaged and the risky pipeline areas. Thus, the objective of this work is to bring a powerful analysis tool for a rigorous pipeline inspection through the implementation of speci?c algorithms dedicated to this application for a precise delimitation of the defective zones and a reliable interpretation of the defect implicated, in spite of the drastic conditions inherent to the evolution of the endoscope inside the pipeline and the quality of the acquired images and videos.
关键词： corrosion detection,video processing,pipeline inspection,thresholding methods,endoscopy
更新于2025-09-23 15:21:01