- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Safety evaluation of fractional CO2 laser treatment in post-menopausal women with vaginal atrophy: A prospective observational study
摘要： Objectives: To evaluate the safety of and patient satisfaction with fractional CO2 laser for the treatment of vulvo-vaginal atrophy (VVA) in postmenopausal patients. Study design: Patients affected by VVA were considered for the study. All women were treated using a Lumenis AcuPulse DUO (Lumenis, Yokneam, Israel) in fractionated mode with a 28 mm probe, FemTouch?. Pain during different steps of the procedure (introduction, rotation and extraction of probe and laser impulse transmission) was evaluated on a 7-point Likert scale. The occurrence of side-effects was evaluated at the end of the procedure, and in the three-month follow-up (after the last treatment) complications were classified as ‘early’ (occurring within 30 days) or late (after 30 days). Participant satisfaction was measured on a 7-point Likert scale (1= strongly disagree, 7= strongly agree). The institutional review board approved the study protocol. Results: Fifty-three women were enrolled in the study. No severe complications occurred after a median follow-up of six months. One patient (1.9 %) reported dizziness immediately after treatment, which completely resolved within 15 min. A minor bleeding occurred related to tip introduction and rotation. One patient (1.9 %) aborted the procedure because of discomfort on probe introduction but decided to repeat the procedure after two weeks. Two patients (3.7 %) reported symptoms of dysuria within 7 days of the procedure. The mean overall pain score at first treatment, evaluated on the 7-point Likert scale, was 3.57 ± 1.50. The mean pain scores related to probe introduction and rotation were 3.13 ± 1.37 and 2.32 ± 1.08, whereas pain scores for extraction and laser impulse transmission were 1.23 ± 0.27 and 1.13 ± 0.37 respectively. Mean overall pain score (1.27; CI 95 % 0.83–1.71, p < 0.001) and pain scores related to probe introduction (0.54; CI 95 % 0.18–0.90, p = 0.001) and probe rotation (0.46; CI 95 % 0.12–0.90, p = 0.003) all statistically significantly decreased between the first and third treatment (Fig. 1). Mean pain scores related to laser activation (0.01; CI 95 % ?0.06 – 0.20, p = 0.07) and extraction (0.08; CI 95 % ?0.04–0.19, p = 0.31) did not change over the course of treatment. Overall, patient satisfaction with the procedure was high: 89.7 % of patients would highly (value 5–7) recommend the procedure and 94.9 % would be ready to repeat the procedure to maintain results. Discomfort related to treatment was lower than expected for 41 % of patients (value 5–7) and as expected for 48.7 % (value 3–4). Conclusion: Fractional CO2 laser for treatment of VVA seems a safe therapeutic option. No severe complications occurred. A minority of patients reported mild complications, but these resolved without the need for treatment. Most discomfort was related to probe introduction and rotation. Overall, patients were highly satisfied, and they would repeat laser treatment.
关键词： Fractional CO2 laser,Dyspareunia,Menopause,Laser safety,Vulvovaginal atrophy
更新于2025-09-23 15:21:01
-
Two-step treatment of bulky keloids on the cheeks after deep chemical peeling: intralesional cryosurgery followed by pulsed dye and ablative fractional CO2 laser
摘要： Scarring of the face following chemical peeling is an uncommon and devastating complication. This case report describes the successful treatment of bulky mature keloids on both cheeks following deep chemical peeling by using a combined approach of intralesional cryosurgery followed by pulsed dye and ablative fractional CO2 laser therapy.
关键词： Keloid,Silicone occlusive sheets,Deep chemical peeling,Pressure garment,PDL ablative fractional CO2 laser,Intralesional cryosurgery
更新于2025-09-23 15:21:01
-
The use of Carboxytherapy alone or in combination with fractional CO2 laser for facial rejuvenation: A splita??face comparative study
摘要： Background A wide variety of minimally invasive treatments are available for skin aging. Recently carbon dioxide therapy (CDT) or carboxytherapy was used in many cosmetic indications including facial rejuvenation. Objective To compare the efficacy of CDT alone versus combined CDT and fractional CO2 laser in management of facial aging. Methods Twenty-Five female patients with bilateral and symmetrical facial aging were included in the study. The right (Rt) hemiface received 8 sessions of CDT whereas the left (Lt) side was treated with combined technique (6 sessions of CDT and 2 sessions of fractional CO2 in between. Clinical and objective evaluation using 3D skin analysis, histological and morphometric analysis were performed. Results Clinical evaluation demonstrated that all patients (100%) were satisfied with no significant difference between both sides of the face (p>0.05). Regarding texture and pigmentation improvement, the Lt side (combined) showed significant improvement compared to the Rt side (p<0.05). Using Antera 3D camera, there was a significant difference (p<0.05) in 3D improvement percent in textural changes while there was no significant difference (p>0.05) in the 3D percent of wrinkles improvement between both sides. The Lt. side showed more significant increase in epidermal thickness after treatment when compared to the Rt. side (p<0.05) with evident neocollagen formation. Conclusion Carboxytherapy is an easy, safe, simple and a relatively effective method for facial rejuvenation with minimal downtime. Better results were achieved when used in combination with fractional CO2 laser.
关键词： skin aging,minimally invasive treatments,fractional CO2 laser,facial rejuvenation,Carboxytherapy
更新于2025-09-23 15:21:01
-
Evaluation of Fractional CO <sub/>2</sub> Versus Long Pulsed Nd:YAG Lasers in Treatment of Hypertrophic Scars and Keloids: A Randomized Clinical Trial
摘要： Background: Keloids and hypertrophic scars are challenging to both patients and physicians. They can be aesthetically disfiguring, functionally debilitating, and emotionally distressing. Lasers have introduced new mechanisms to improve scars both on aesthetic and symptomatic levels. Aim of Work: Comparing the efficacy of fractional CO2 laser, long‐pulsed Nd:YAG laser and their combination in the treatment of hypertrophic scars and keloids on clinical, histopathological, and biochemical basis. Patients and Methods: Thirty patients with hypertrophic scars and keloids were enrolled in the study. Three scars in each patient were randomly assigned to treatment modalities (i) Fractional CO2, (ii) Nd:YAG laser, (iii) Combined CO2 and Nd:YAG lasers. For each treatment area four sessions, 4–6 weeks apart were performed. Clinical evaluation was done before and 1 month following last session using the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS). Routine hematoxylin and eosin, Masson's trichrome, and Orcein stains were used to evaluate the appearance and pattern of dermal collagen and elastic fibers. Image analysis was used to quantitatively assess the density of collagen and elastic fibers. Biochemical evaluation of tissue level of transforming growth factor‐β I (TGF‐β I) and TGF‐β III was performed using enzyme‐linked immunosorbent assay studies. Results: Both VSS and POSAS showed significant improvement following treatment with the three used modalities. Collagen fibers showed significant improvement as regards appearance and pattern while it was insignificant as regards density. Elastic fibers density improvement was only significant in fractional CO2 (treatment area A). Hypertrophic scars showed more significant improvement with fractional CO2 laser, while in keloids there was no significant difference between the three modalities regarding improvement. Level of TGF‐β I showed significant reduction after treatment in all treatment modalities, while TGF‐β III levels showed insignificant elevation in all treatment modalities. Side effects were significantly higher in treatment area C (combined treatment). Conclusion: Long pulsed Nd:YAG laser is effective and safe treatment of hypertrophic scars and keloids. Fractional CO2 laser yields better improvement in hypertrophic scars, while in keloids both fractional CO2 and Nd:YAG lasers achieve comparable improvement. Combination in the same session did not add significant additional benefit and the side effects profile was higher. Limitations: small sample size and short follow‐up period.
关键词： fractional CO2 laser,Nd:YAG laser,keloids,hypertrophic scars,RCT
更新于2025-09-23 15:19:57
-
Fractional carbon dioxide laser combined with intradermal injection of autologous plateleta??rich plasma versus noncrossa??linked hyaluronic acid in the treatment of atrophic postacne scars: A split face study
摘要： Background: Atrophic acne scarring is a common cosmetic problem that may affect 95% of patients with acne. Aims: The objective is to evaluate the efficacy of the fractional CO2 laser combined with intradermal injection of PRP versus intradermal injection of noncross-linked hyaluronic acid in the treatment of different types of atrophic postacne scars. Methods: The study included 30 patients with postacne scars. All the patients received 3 treatments of fractional CO2 laser combined with intradermal injection of PRP at one side of the face compared with intradermal injection of noncross-linked hyaluronic acid at the other side of the face. Efficacy of the treatment was assessed by the physician's clinical assessment using Goodman and Baron's qualitative and quantitative grading systems and histopathological evaluation from six participants. Results: The study included 30 patients ages ranging from 25 to 44 years old. There was a statistically significant reduction in the severity of acne scars on both sides after treatment using qualitative and quantitative Goodman and Baron. Histopathological evaluation showed an increase in the collagen and elastic fiber content in both modalities with a more favorable outcome in the PRP-treated side. Conclusion: Both treatment modalities resulted in a significant clinical and histopathological improvement in atrophic postacne scar with insignificant difference between them.
关键词： HA,postacne scar,fractional CO2 laser,PRP
更新于2025-09-23 15:19:57
-
Commentary on the Photomicrodebridement of Unstable Burn Scars Using Ablative Fractional CO2 Laser
摘要： Brown and colleagues describe a case of a 25% total body surface area burn patient with a course complicated by contractures, scar hypertrophy, and chronic skin breakdown despite grafts, multiple release procedures, and wound care. The authors treated her hypertrophic scars and open wounds with photomicrodebridement using ablative fractional (AF) carbon dioxide (CO2) laser (10,600 nm, UltraPulse; Lumenis, Ltd, DeepFx Hand Piece, 100 mJ/cm2, 3% density) followed by topical Kenalog 10 mg/ml and a bandage with betamethasone. Response was “dramatic” with evidence of almost complete wound closure by Day 10.
关键词： Photomicrodebridement,Laser-assisted drug delivery,Betamethasone,Kenalog,Unstable Burn Scars,Ablative Fractional CO2 Laser
更新于2025-09-12 10:27:22
-
Fractional CO2 laser is as effective as Pulsed Dye laser for the treatment of Hypertrophic scars
摘要： Background: Both pulsed dye laser(PDL) and Fractional CO2 laser(FCO2L) are used commonly for the treatment of hypertrophic scars. Objective: to compare the efficacy of PDL and FCO2L on hypertrophic scars. Patients and Method: One part of each scar, or one of the two similar scars in 35 patients were treated with PDL and the other parts, or scars were treated with FCO2L. The parameters used for FCO2L were: Power=30 watts, Pulse energy=50 mJoules, Density = 200spots/cm2. The parameters used for 585 nm PDL were 9 joules/cm2 with 5mm spot size. The FCO2L side were treated for 3 passes to debulk the scar. The coagulated tissue was wiped out before the next pass. The PDL side were treated with 2 superimposed passes. The procedures repeated every month for 4 months. Results: after 4 sessions of laser therapy, both sides showed remarkable improvement but no meaningful difference detected between 2 areas that were treated with PDL and fractional CO2 lasers (p?0.05). The mean Vancouver scar scale was 7.31±1.93 In the beginning and 4.26±1.48 for FCO2L and 4.33±1.70 for PDL one months after the final session. Conclusion: both PDL and Fractional CO2 lasers were equally effective on hypertrophic scars.
关键词： Pulsed Dye Laser,Hypertrophic scar,Fractional CO2 laser
更新于2025-09-12 10:27:22
-
Fractional CO2 laser plus topical antifungal versus fractional CO2 laser versus topical antifungal in the treatment of onychomycosis
摘要： Introduction: Onychomycosis is an important medical disorder affecting both patients’ health and quality of life. Objective: This study was done to compare the efficacy of CO2 laser in combination with topical tioconazole versus CO2 laser only versus topical tioconazole alone in onychomycosis. Patients and methods: A total of 120 patients with onychomycosis were randomly assigned to 3 groups. Group A patients were treated with fractional CO2 laser followed by topical tioconazole 28% for 5 sessions with 3 weeks interval. Group B patients were treated with only fractional CO2 laser for 5 sessions with 3 weeks interval. Group C patients were treated with only topical tioconazole 28% for 16 weeks. The clinical effect, KOH examination, and culture for the affected nails in the 3 groups were analyzed. Results: One month after last session, regarding clinical response, 55% showed complete clinical improvement in group A versus 30% in group B versus 25% in group C with significant difference in between. There was a significant difference between the three studied groups as regard KOH test and culture after treatment. Conclusion: Fractional CO2 laser combined with topical antifungal is a safe and effective treatment for onychomycosis.
关键词： Onychomycosis,Fractional CO2 Laser,Tioconazole
更新于2025-09-12 10:27:22
-
High- Versus Low-Density Fractional Laser in the Treatment of Hypertrophic Postburn Scars
摘要： BACKGROUND Fractional CO2 laser has been shown effective in improving pigmentation, pruritus, and tightness of hypertrophic burn scars. However, there is no consensus on the optimal treatment parameters. OBJECTIVE To compare effectiveness of different densities of fractional CO2 laser in the treatment of mature hypertrophic burn scars. MATERIALS AND METHODS The study included 25 patients, each with 3 or more mature hypertrophic burn scars. Scars were randomly assigned to treatment with low-, medium-, and high-density fractional CO2 laser. Each scar received 3 sessions of laser at 1-month interval. The degree of improvement was assessed clinically using Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) scores, and histologically through evaluation of collagen (Masson’s Trichrome stain) before and 1 month after end of therapy. RESULTS High-density parameters showed significant higher improvement in VSS and POSAS assessment scores (p-value < .001). Pliability and relief are the most improved parameters. Histopathological evaluation revealed a significant drop in the mean area percent of collagen in the 3 used parameters, with highest improvement with high-density laser treatment (p-value < .001). CONCLUSION High-density fractional CO2 laser treatment provides more improvement in burn scars both clinically and histopathologically.
关键词： hypertrophic burn scars,collagen,Fractional CO2 laser,Patient and Observer Scar Assessment Scale,Vancouver Scar Scale
更新于2025-09-12 10:27:22
-
Photodynamic therapy following fractional CO <sub/>2</sub> laser for treatment of primary vulvar Paget’s disease: does it really work?
摘要： Introduction: Extra-mammary Paget’s disease is a rare form of intraepithelial adenocarcinoma with a variable pattern of invasion. Vulvar Paget’s disease represents 1% of all vulvar cancers. Standard treatment is surgical excision, however, the recurrence rate is high and surgery leads to anatomical, functional and sexual morbidity. Some studies suggest the efficacy of photodynamic therapy following CO2 Laser irradiation as treatment for this disease. Methods: In the present study, ten patients with vulvar Paget’s disease underwent fractional carbon dioxide (CO2) laser abrasion, followed by 3 h of occlusive application of aminolaevulinic acid (ALA) and then 100 J/cm2 irradiation with a 630-nm lamp. This combination treatment regime was repeated every 2 weeks for a total of 5 times. Results: At the end of the 12-month follow-up period, only two patients maintained a complete remission of the disease and recurrence was observed in all patients who had originally shown a partial remission. Conclusions: According to our experience, Photodynamic Therapy-ALA following fractional CO2 Laser does not seem to be an effective treatment for vulvar EMPD in the long term.
关键词： photodynamic therapy,fractional CO2 laser,Paget disease
更新于2025-09-12 10:27:22