- 标题
- 摘要
- 关键词
- 实验方案
- 产品
过滤筛选
- 2017
- spectral reconstruction
- interference
- polarization
- transform
- imaging spectrometer
- Optoelectronic Information Science and Engineering
- BITTT
- Zhejiang University
- Guilin University of Aerospace Technology
-
Comparison of different non-invasive diagnostic techniques used for HMME-PDT in the treatment of port wine stains
摘要： Background: Hemoporfin-mediated photodynamic therapy (HMME-PDT) is an effective method for treating port wine stains (PWS). While, it still lacks methods to evaluate the treatment of HMME-PDT for PWS effectively and objectively. Objective: This study aimed to compare the value of different non-invasive diagnostic techniques used for HMME-PDT treatment evaluation in PWS. Methods: Thirty-one lesions of 22 patients with PWS were treated with HMME-PDT. Four non-invasive diagnostic techniques including VISIA-CRTM system, dermoscopy, high-frequency ultrasound (HFUS) and laser speckle imager (LSCI) were used to obtain standard radiographic data containing skin color, skin thickness, blood vessel morphology, blood vessel distribution and blood perfusion from lesions and normal skin surrounded before and after HMME-PDT. Results: The standard image pattern of VISIA-CRTM system showed color change of the lesions of PWS after HMME-PDT. RBX-red image of VISIA-CRTM system showed that erythema was highly aggregated even on invisible lesions at baseline but decreased after HMME-PDT. The erythema index reduced value d was related to the efficacy rating (γ=0.631, P＜0.05). Dermoscopy showed that the number of spot-like and irregular linear vessels increased correlated with increase of clinical classification. After HMME-PDT, vascular rupture was observed by dermoscopy. The response rate of lesions with vascular rupture was 100.00% (20/20). And the response rate of lesions without vascular rupture was 63.64% (7/11). Vascular rupture sign was correlated with better efficacy (P＜0.05). High-frequency ultrasound showed that dermis of PWS thickened and arranged loosely with scattered linear hypoechoic signal. After HMME-PDT, the dermal layer of the lesions became thinner with the linear hypoechoic signal decreased. The response rate of lesions with linear hypoechoic signal was 76.92% (10/13), and that without linear hypoechoic signal was 94.44% (17/18). The lesions without linear hypoechoic signal in dermis showed better efficacy (P＜0.05). In some lesions, Laser speckle contrast showed high blood perfusion signal in PWS lesions and a blood perfusion reduction after HMME-PDT. Conclusion: VISIA-CRTM system can be used to observe not only visible but also invisible lesions of PWS. Moreover, lesions fading after HMME-PDT treatment can be described objectively by VISIA-CRTM system. Dermoscopy played an important role in the clinical classification of PWS, including assessing vascular injury after HMME-PDT, guiding the adjustment of therapeutic dose, and selecting the end point of treatment. HFUS and LSCI can be both used to assist the treatment response evaluation of HMME-PDT.
关键词： dermoscopy,port-wine stains,laser speckle contrast imaging,hemoporfin-mediated photodynamic therapy,VISIA-CRTM system,high-frequency ultrasound
更新于2025-09-23 15:23:52
-
[IEEE 2018 IEEE International Ultrasonics Symposium (IUS) - Kobe, Japan (2018.10.22-2018.10.25)] 2018 IEEE International Ultrasonics Symposium (IUS) - Simulation of Photoacoustic Imaging of Red Blood Cell Aggregation Using a Numerical Model of Pulsatile Blood Flow
摘要： Photocatalytic imaging of blood flow using a pulsed laser diode of semiconductor blood flow aggregation and oxygenation saturation (sO2) estimation. During blood flow aggregation, the oxygen saturation of the blood flow is affected by the interaction between red blood cell (RBC) aggregation and the oxygen saturation (sO2) [1-7]. The mechanism of the aggregation is not yet fully understood. To date, two models, namely the bridging and depletion models, are proposed for explaining the kinetics of RBC aggregation [20-21]. Using the proposed models, new efforts have been published to investigate the kinetics of RBC aggregation [22-24]. In this paper, a simple particle motion model in two-dimensional (2D) space was introduced to understand the photothermal imaging of blood flow aggregation from the flow model. The flow model consisted of 125 elements spaced at 10 μm center-to-center, yielding a lateral length of 22.0 mm. The incident laser fluence was less than 10 mJ/cm2, below the safety limit by the American National Standards Institute (ANSI) for these wavelengths. The photothermal power (PTP) was computed from the flow model at each time step, and the simulated PTP was compared to the measured PTP in vivo. From the comparison, the kinetics of RBC aggregation was studied.
关键词： blood flow,aggregation,photocatalytic imaging,photothermal power,kinetics,red blood cell,oxygenation saturation
更新于2025-09-23 15:23:52
-
[IEEE IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium - Valencia (2018.7.22-2018.7.27)] IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium - Processing a New Hyperspectral Data Set for Target Detection and Atmospheric Compensation Algorithm Assessment: The RIT2017 Data Set
摘要： This paper introduces a new and challenging hyperspectral dataset to the remote sensing community called the 'RIT2017 Data Set' which can be used for the assessment of target detection algorithms. This dataset encompasses 90 targets in a background of up to 8 million pixels (or less if sub-setting). The same dataset can also be used for atmospheric compensation studies for it has identical sets of large panels in both the sun and full shadow. This paper briefly introduces the data collection campaign, the target objects, and addresses the radiometric fidelity of the imaging spectrometer data, which showed very good results. Lastly, the data is atmospherically compensated using an in-scene technique, which also showed fairly good results.
关键词： atmospheric compensation,physics-based modeling,hyperspectral imaging,target detection,radiative transfer
更新于2025-09-23 15:23:52
-
[IEEE IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium - Valencia (2018.7.22-2018.7.27)] IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium - Hybrid Parametric - Nonparametric Target Detector for Hyperspectral Images
摘要： In this work a novel target detector is proposed that is nonparametric in terms of conditional probability density function (pdf) estimation and parametric with respect to the target strength of the additive model it relies upon. The variable bandwidth kernel density estimator is employed to estimate the conditional pdfs, whereas the target strength is estimated via the Maximum Likelihood approach. Experimental results over real hyperspectral data show that the detector succeeds in detecting target objects embedded in a complex background and in providing reasonable estimates for the target strengths.
关键词： nonparametric approach,kernel density estimation,additive model,target detection,Hyperspectral imaging
更新于2025-09-23 15:23:52
-
Research on indocyanine green angiography for predicting postoperative hypoparathyroidism
摘要： Background: It may be critical to locate the parathyroid for surgeons during thyroidectomy or parathyroidectomy due to the significant function of the parathyroid in calcium balance. According to recent reports, the intrinsic fluorescence of the parathyroid has been found. There is some evidence supporting that new equipment can detect fluorescence via imaging technology. In this study, a newly-invented intraoperative fluorescence imaging system and indocyanine green dye were applied to detect the parathyroid glands and evaluate the vascularization of the parathyroid. The report is as follows. Methods: From May 1st to August 8st, 2018, 26 patients underwent total thyroidectomy in Zhuhai People’s Hospital and were recruited into our research. All identified parathyroid glands were scored visually from grade 0 to grade 2 according to the vascularity of the parathyroid before ICG angiography was performed. After ICG angiography, parathyroid glands were scored from score 0 to score 2 according to the FI. Results: Visual scores were significantly higher than ICG angiography scores. In the 22 patients with at least one parathyroid gland with an ICG score of 2, postoperative PTH levels were in the normal range. In the 4 patients with no parathyroid gland with an ICG score of 2, 2 of them developed transient hypoparathyroidism, with recovery on POD 7 for the first patient and after 3 months for the second one. Conclusion: This study has identified that the fluorescence imaging system applied with indocyanine green is a safe, easy and effective method to protect the parathyroid and predict postoperative hypoparathyroidism. Registration number: ChiCTR1800016864.
关键词： Fluorescence imaging system,Indocyanine green,Postoperative hypoparathyroidism.,Parathyroid
更新于2025-09-23 15:23:52
-
Quantitative cosmetic evaluation of long-lasting foundation using multispectral imaging
摘要： Background: We tried to search appropriate wavelength to quantitatively evaluate the ability of long- lasting foundation using a hyperspectral imager (HSI) which can simultaneously measure position and wavelength information. Materials and methods: A good reputable long- lasting foundation was applied to the skin of 10 healthy volunteers. Their skin was measured by our newly developed HSI every 2 hours from immediately after application to 6 hours. The application state of the foundation was quantified using the standard deviation of reflectance. Results: A high correlation between standard deviation and the application state of the foundation was confirmed at many wavelengths. In particular, it was suggested that by using the standard deviation of 800 nm, the application state of the foundation can be evaluated quantitatively without depending on the subject’s oxygen saturation level. Conclusion: By quantitatively evaluating the cosmetic- applied skin by our system, further efficiency improvement of the volunteer experiment is expected.
关键词： cosmetic evaluation,spectrum analysis,long-lasting foundation,hyperspectral imaging
更新于2025-09-23 15:23:52
-
Image of O2 dynamics released by oak wood submerged in model wine with nanoparticle sensors
摘要： Oxidation of wine while in contact with oak wood is a well-known fact and recognized as an important process in wine ageing. The slow and continuous di?usion of oxygen from the oak wood entrapped in its porosity occurs and encourages the reactions usually related with wine aging. In this work, oxygen sensitive particles were used to study the oxygen dynamics from di?erent anatomical regions of the oak wood and simultaneously the oxygen increasement because of the deoxygenation of the wood and the oxygen depletion due to its consumption by the tannins and other compounds released from the wood. To this end, core-shell-type PSPVP nanoparticles stained with Macrolex Fluorescence Yellow and Pt-TFPP were employed as reference and oxygen-sensitive particles respectively. Moreover, a Guppy Pro RGB camera was employed to monitor the particles performing ratiometric oxygen imaging, using the green and red channels to acquire the light emitted from the reference and the oxygen-sensitive particles respectively. Because the volume of nanosensors corresponding to each surface unit is very di?erent from that of the wood region, di?erent exposure times were chosen to obtain the images at each of the times. The results show the wood degassing process during the ?rst minutes of the experiment, the oxygen release from di?erent structural elements of the wood, its consumption by the released compounds from wood and the di?usion of the oxygen through the model wine.
关键词： Nanoparticles,Wine,Oxygen consumption,Optical oxygen imaging,Oak wood
更新于2025-09-23 15:23:52
-
Image classification with quantum pre-training and auto-encoders
摘要： Computer vision has a wide range of applications from medical image analysis to robotics. Over the past few years, the field has been transformed by machine learning and stands to benefit from potential advances in quantum computing. The main challenge for processing images on current and near-term quantum devices is the size of the data such devices can process. Images can be large, multidimensional and have multiple color channels. Current machine learning approaches to computer vision that exploit quantum resources require a significant amount of manual pre-processing of the images in order to be able to fit them onto the device. This paper proposes a framework to address the problem of processing large scale data on small quantum devices. This framework does not require any dataset-specific processing or information and works on large, grayscale and RGB images. Furthermore, it is capable of scaling to larger quantum hardware architectures as they become available. In the proposed approach, a classical autoencoder is trained to compress the image data to a size that can be loaded onto a quantum device. Then, a Restricted Boltzmann Machine (RBM) is trained on the D-Wave device using the compressed data, and the weights from the RBM are then used to initialize a neural network for image classification. Results are demonstrated on two MNIST datasets and two medical imaging datasets.
关键词： quantum machine learning,medical imaging,Quantum computing,machine learning
更新于2025-09-23 15:23:52
-
Facile, rapid one-pot synthesis of multifunctional gold nanoclusters for cell imaging, hydrogen sulfide detection and pH sensing
摘要： In this study, we have developed a facile, rapid one-pot strategy for synthesis of orange fluorescent gold nanoclusters (MBISA–AuNCs) at room temperature by using 2-Mercapto-5-benzimidazolesulfonic acid (MBISA) as both reducing and protecting reagent. The prepared AuNCs exhibited prominent advantages including high fluorescent quantum yield, good water solubility, excellent biocompatibility and low toxicity. Based on these superior properties, the AuNCs have been multi-talented applied in cell imaging, hydrogen sulfide detection and pH sensing. Confocal fluorescence imaging showed that the MBISA–AuNCs could enter living cells and distribute in the cytoplasm. Additionally, the obtained AuNCs could visualize H2S fluctuations in living cells without interference of autofluorescence based on their high sensitivity and selectivity detection for H2S with a linear range of 2.7 × 10–11–8.5 × 10?4 M and a detection limit of 0.024 nM. Most strikingly, the AuNCs exhibited strong pH dependent behavior and responded linearly, rapidly and reversibly to minor pH fluctuations within the range of 2.01–12.00. Therefore, the AuNCs could also image pH fluctuations in live cells with negligible autofluorescence and provided a new method of analysis to visualize monitoring wide pH range change in live cells.
关键词： Cell imaging,pH sensor,Gold nanoclusters,Fluorescence,Hydrogen sulfide
更新于2025-09-23 15:23:52
-
A coumarin-based colorimetric fluorescent probe for rapid response and highly sensitive detection of hydrogen sulfide in living cells
摘要： Hydrogen sulfide (H2S) plays a vital role in numerous biological processes in living organisms. To better understand its functions, a fluorescent probe to fast and sensitively detect H2S is imminently needed. Keep this in mind, we reasonably designed probe DHC for detecting H2S based on α, β-unsaturated ethanoylcoumarin fluorophore. The limit of detection (LOD) is found to be as low as 5 × 10?8 M, which is superior to most reported fluorescent probes to detect H2S. Furthermore, the wide pH range of 4–11 makes it capable of application in biological systems. Most importantly, MTT assays and cell imaging experiments indicate that probe DHC has hypotoxicity and outstanding membrane permeability, which makes DHC successful imaging of H2S in Baby Hamster Syrian Kidney (BHK) cells.
关键词： Cell-imaging,Fluorescent probe,Rapid response,H2S,Coumarin
更新于2025-09-23 15:23:52