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- 摘要
- 关键词
- 实验方案
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过滤筛选
- 2017
- spectral reconstruction
- interference
- polarization
- transform
- imaging spectrometer
- Optoelectronic Information Science and Engineering
- BITTT
- Zhejiang University
- Guilin University of Aerospace Technology
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Light in power
摘要： We present in this paper a generic and parameter-free algorithm to efficiently build a wide variety of optical components, such as mirrors or lenses, that satisfy some light energy constraints. In all of our problems, one is given a collimated or point light source and a desired illumination after reflection or refraction and the goal is to design the geometry of a mirror or lens which transports exactly the light emitted by the source onto the target. We first propose a general framework and show that eight different optical component design problems amount to solving a light energy conservation equation that involves the computation of visibility diagrams. We then show that these diagrams all have the same structure and can be obtained by intersecting a 3D Power diagram with a planar or spherical domain. This allows us to propose an efficient and fully generic algorithm capable to solve these eight optical component design problems. The support of the prescribed target illumination can be a set of directions or a set of points located at a finite distance. Our solutions satisfy design constraints such as convexity or concavity. We show the effectiveness of our algorithm on simulated and fabricated examples.
关键词： Mirror design,Caustics,Lens design,Power diagram,Optimal Transport,Non-imaging Optics
更新于2025-09-23 15:23:52
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Fluorescent Ag clusters conjugated with anterior gradient-2 antigen aptamer for specific detection of cancer cells
摘要： Fluorescent probes with small size, low toxic and specific recognition are of fundamental interests as well as of practical prospects in bioimaging. Though various probes have been reported up to now, including traditional organic dye, quantum dots, rare earth-based particles, and recently emerged carbon dots, silicon dots, polymer dots and metal cluster et al., the relatively large size and lack of specify are far from satisfaction in cellular imaging. As confirmed in previous reports, the large size might influence the functions of target, where the consequent drawback of non-specific is requiring conjugate with additional ligands which brings even larger size and complex procedures. In such a context, fluorescent metal nanoclusters have rapidly attracted widely concern for their integrated advantages of small size, high stability, unique selectivity and tunable properties by simply selecting different stabilizer. In considering a wide variety of stabilizer, aptamer, as a class of ssDNA, has received particular interest because of the easy production, reduced size comparing with antibody and selectively binding ability in molecule level with specific structures. Former researches have proved that cytosine has strong interaction with Ag cations. Therefore, colorful Ag clusters (AgNCs) have been continuously prepared using different DNA sequences in a simple reductive reaction after mixing both aptamer and Ag cation. Additionally, the as synthesized AgNCs do not influence the selectivity of the aptamer itself. For example, Sun et al. reported a one-step process to synthesize silver nanoclusters by specific aptamer which can selectively image the nuclei of CCRF cells, clearly demonstrates the strength of the aptamer capsulated Ag clusters. Anterior gradient protein 2 homolog (AGR), a homolog of xenopus anterior gradient-2 (XAG-2) of Xenopus laevis, is a typical protein that secret by gland cancer cell. Since being discovered as a pro-oncogenic protein that weakens p53 gene activity in 2004. Clinical studies have shown that AGR is highly expressed in pancreatic, breast, and prostate cancer cells, etc. The molecular function and clinical relevance of AGR with variety cancers have thus been increasingly investigated. Specifically, it is a functional protein that plays a key role in variety of biological systems, including the development of vertebrate tissue and the inflammatory tissue injury response. Overall, Tian's results demonstrated that AGR overexpression could predict poor overall survival (OS) and poor time to tumor progression (TTP) of all solid tumor patients. Therefore, fluorescence recognizing of AGR is important for detecting gland cancer cells. At present, a number of reports related with AGR have been reported, but few on specific recognition probes. Through a series of screening, Wu et al. discovered AGR's corresponding aptamer “C14B1”. Few years later, Hu et al. successfully achieved the direct detection of AGR in vitro. However, in the cell imaging field, there is scarcely report on AGR detection. Therefore, synthesis of fluorescent AgNCs conjugating with aptamer to target AGR could provide a novel method for recognizing human gland cancer cell with a high selectivity, efficiency, and low cytotoxicity. In this paper, modified AGR aptamer (MA) were used as template to synthesize AgNCs. Specifically, MA's sequence is 5′-CGG GTG GGA GTT GTG GGG GGG GGT GGG AGG GTT TTTTT CCC CCC CCC CCC-3′ (50 bases). This sequence consists of two functional parts, AGR-apt sequence for recognition AGR in breast cancer (MCF-7) cells, where 12 cytosine base sequence (12C) for effectively preparing fluorescent AgNCs. According to Li's research, a T5 loop (-TTTTT-) could enhance the fluorescence intensity and avoid the influence of space hindrance. It was incorporated between the 3′ end of the apt and 12C sequence. Eventually, according to optimized reaction conditions, MA stabilized silver nanocluster (MA@AgNCs) with a small size, suitable stability, good selectivity was prepared. The fluorescence excitation peak and emission peak of MA@AgNCs were located at 510 nm and 565 nm respectively with a quantum yield as high as 87.43%. Moreover, MA@AgNCs shows descent specific recognition of MCF-7 cells, suggesting the prepared MA@AgNCs have the ability to selective target gland cancer cell and potentially utilized for clinical diagnosis and treatment.
关键词： Bio-probe,Cell imaging,Anterior gradient-2 antigen,Silver nanoclusters,Aptamer
更新于2025-09-23 15:23:52
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Deep multispectral painting reproduction via multi-layer, custom-ink printing
摘要： We propose a workflow for spectral reproduction of paintings, which captures a painting's spectral color, invariant to illumination, and reproduces it using multi-material 3D printing. We take advantage of the current 3D printers' capabilities of combining highly concentrated inks with a large number of layers, to expand the spectral gamut of a set of inks. We use a data-driven method to both predict the spectrum of a printed ink stack and optimize for the stack layout that best matches a target spectrum. This bidirectional mapping is modeled using a pair of neural networks, which are optimized through a problem-specific multi-objective loss function. Our loss function helps find the best possible ink layout resulting in the balance between spectral reproduction and colorimetric accuracy under a multitude of illuminants. In addition, we introduce a novel spectral vector error diffusion algorithm based on combining color contoning and halftoning, which simultaneously solves the layout discretization and color quantization problems, accurately and efficiently. Our workflow outperforms the state-of-the-art models for spectral prediction and layout optimization. We demonstrate reproduction of a number of real paintings and historically important pigments using our prototype implementation that uses 10 custom inks with varying spectra and a resin-based 3D printer.
关键词： spectral reproduction,3d printing,multi-spectral imaging
更新于2025-09-23 15:23:52
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Current Status of Patient Radiation Exposure of Cardiac Positron Emission Tomography and Single-Photon Emission Computed Tomographic Myocardial Perfusion Imaging
摘要： BACKGROUND: Radiation exposure during nuclear cardiology procedures has received much attention and has prompted citations for radiation reduction. In 2010, the American Society of Nuclear Cardiology recommended reducing the average patient study radiation exposure to <9 mSv in 50% of studies by 2014. Cardiac positron emission tomography (PET) for myocardial perfusion imaging (MPI) has emerged within recent years, but current radiation exposure in cardiac nuclear PET laboratories is unknown. This study evaluated current reported patient radiation exposure from nuclear laboratories in the United States applying for Intersocietal Accreditation Commission accreditation for MPI using single photon emission computed tomography (SPECT) or PET. METHODS AND RESULTS: This was an analysis of nuclear cardiology studies submitted to the Intersocietal Accreditation Commission for either or both cardiac PET and SPECT accreditation. Cardiac SPECT data represented year 2015 while PET data combined years 2013 to 2015. Data was analyzed with χ2 and Mann-Whitney U tests (reported as median, 25th percentile, and 75th percentile). Reported PET MPI radiation exposure for 111 laboratories (532 patient cases) was 3.7 (3.2–4.1) mSv per study with no geographic variation. Reported SPECT MPI radiation exposure for 665 laboratories (3067 patient studies) was 12.8 (12.2–14.3) mSv. Highest radiation exposure was found in the South region. Technetium-only studies resulted in a median of 12.2 mSv per study. CONCLUSIONS: Radiation exposure from cardiac PET MPI in US laboratories applying for Intersocietal Accreditation Commission accreditation is low (111 laboratories, 3.7 mSv) and substantially lower than cardiac SPECT (665 laboratories, 12.8 mSv).
关键词： technetium,accreditation,myocardial perfusion imaging,positron emission tomography,radiation exposure
更新于2025-09-23 15:23:52
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The Usefulness of Dual-Volume Visualization (Three-Dimensional Digital Subtraction Angiography and Cross-Sectional Imaging) for Surgical Planning in Treating Intracranial Meningiomas: A Case Series and Technical Report
摘要： In presurgical planning for intracranial meningiomas, the relationship between tumors and adjacent vasculature must be identified. The purpose of this study was to evaluate the usefulness of 3-dimensional digital subtraction angiography (3D-DSA) with dual-volume visualization (DVV). Between February 2013 and April 2016, 26 patients with intracranial meningiomas enrolled in this study. Two or 3 days before surgery, 3D-DSA with DVV was performed for presurgical planning. If necessary, the tumor was simultaneously embolized. Vascular supply and disfiguration observed by preoperative 3D-DSA with DVV closely resembled those actually observed during surgery. All but 2 patients had total tumor resection (Simpson grade 1 or 2). Three of 26 patients had new neurologic deficits. 3D-DSA with DVV may be useful for preoperative planning by allowing the surgeon to identify the relationship between a tumor and peritumoral vasculature before meningioma surgery. Young neurosurgeons with little experience may benefit most from this technique.
关键词： Meningioma,Digital subtraction angiography,Three-dimensional imaging,Computer-assisted surgery
更新于2025-09-23 15:23:52
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Time reversal imaging based on joint space–frequency and frequency–frequency data
摘要： A new time reversal (TR) method for target imaging is proposed in this paper. Through single measurement by the antenna array, the received signals are utilized to form the space–frequency–frequency multistatic data matrix (MDM). Singular value decomposition is applied to the matrix to obtain the left singular vectors which span the signal subspace. The obtained vectors are divided into multiple subvectors by two different schemes and used to provide target signatures in the form of coarse frequency dependence and relative phase shifts that can be exploited to construct the imaging function. The performance of the proposed method is investigated through numerical simulations for both single and multiple targets, and the results are compared with the traditional TR method using the frequency–frequency MDM. It turned out that the proposed method is able to achieve high resolution with limited array aperture and shows satisfactory robustness in noise environment. Furthermore, experimental results are provided to show the availability of the method in practical applications.
关键词： time reversal imaging,EM field theory,Radar
更新于2025-09-23 15:23:52
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Imaging extracellular vesicles: current and emerging methods
摘要： Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They range from 30 nm to several micrometers in diameter, and ferry biological cargos such as proteins, lipids, RNAs and DNAs for local and distant intercellular communications. EVs have since been found to play a role in development, as well as in diseases including cancers. To elucidate the roles of EVs, researchers have established different methods to visualize and study their spatiotemporal properties. However, since EV are nanometer-sized, imaging them demands a full understanding of each labeling strategy to ensure accurate monitoring. This review covers current and emerging strategies for EV imaging for prospective studies.
关键词： Bioluminescence,MRI,Microvesicles,SPECT,Biodistribution,Imaging,Extracellular vesicles,Fluorescence,Dyes,exosomes
更新于2025-09-23 15:23:52
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A promising family of fluorescent water-soluble aza-BODIPY dyes for in vivo molecular imaging
摘要： A new family of water-soluble and bioconjugatable aza-BODIPY fluorophores was designed and synthesized using a boron-functionalization strategy. These dissymmetric bis-ammonium aza-BODIPY dyes present optimal properties for a fluorescent probe, i.e. they are highly water-soluble, very stable in physiological medium, they do not aggregate in PBS, possess high quantum yield and finally they can be easily bioconjugated to antibodies. Preliminary in vitro and in vivo studies were performed for one of these fluorophores to image PD-L1 (Programmed Death-Ligand 1), highlighting the high potential of these new probes for future in vivo optical imaging studies.
关键词： molecular Imaging,Fluorescent probes,boron functionalization,aza-BODIPY,Water-soluble fluorophores
更新于2025-09-23 15:23:52
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Modified Sagnac imaging spectropolarimeter for full linear Stokes parameters
摘要： A modified Sagnac imaging spectropolarimeter is conceptually described. It consists of a spectral-polarimetric modulator, a modified Sagnac interferometer with large optical path difference, and a CCD camera. This design modulates the Stokes components of the input light into different wave numbers and obtains the modulated interferogram in snapshot mode, and the spectra of the Stokes components can be separated and demodulated from the interferogram. The performance of the system is demonstrated through a numerical simulation, and a novel method is proposed to detect the polarization parameters including the degree of polarization and polarization direction for eliminating the aliasing effects between linear Stokes parameters. Compared with the existing imaging spectrometers, the modified Sagnac imaging spectropolarimeter can acquire one-dimensional spatial information and its full linear spectropolarimetric information in one exposure, and some other spatial information can be obtained by push-broom mode.
关键词： imaging spectropolarimeter,snapshot mode,Stokes parameters,polarization,Sagnac interferometer
更新于2025-09-23 15:23:52
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Novel Phased Array-Fed Dual-Reflector Antenna with Different Orthogonal Cross-Section by Imaging Reflector Antenna and Ring-Focus Cassegrain Antenna
摘要： We propose a novel phased array-fed dual-re?ector antenna that reduces performance degradation caused by multiple re?ection. The marked feature of the proposed con?guration is that di?erent re?ector pro?les are employed for the two orthogonal directions. The re?ector pro?le in the beam-scanning section (vertical section) is set to an imaging re?ector con?guration, while the pro?le in the orthogonal non-beam-scanning section (horizontal section) is set to a ring-focus Cassegrain antenna con?guration. In order to compare the proposed antenna with the conventional antenna in which multiple re?ection was problematic, we designed a prototype antenna of the same size, and veri?ed the validity of the proposed antenna. The results of the veri?cation were that the gain in the designed central frequency increased by 0.4 dB, and the ripple of the gain frequency properties that was produced by multiple re?ection was decreased by 1.1 dB. These results demonstrated the validity of the proposed antenna.
关键词： Beam-Scanning Function,Imaging Re?ector Antenna,Ring-focus Cassegrain Antenna,Center-Fed Re?ector Antenna,Phased Array-fed Re?ector Antenna,Doubly Curved Re?ector
更新于2025-09-23 15:23:52