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The influence of educational measures and low-level laser phototherapy on temporomandibular disorders
摘要： Photobiomodulation therapy (PBMT) with low-power laser is used for pain relief in several clinical conditions, including temporomandibular disorders (TMD). As musculoskeletal pain often produces changes in motor behavior, it is common for patients with TMD to present limited mandibular movements. To the date, there is no consensus about the optimal dosimetric parameters of PMBT for TMD. This randomized, controlled, double-blind clinical trial aims to evaluate pain relief and mandibular mobility in patients with TMD following treatments with 2 laser wavelengths, red (660 nm) and infrared (808 nm) individually and in combination as compared to a placebo treatment. One-hundred participants presenting myalgia and arthralgia, with disk displacement or not, will be selected based on the Research Diagnostic Criteria for Temporomandibular Disorders. All participants will be instructed about the etiology, prognosis, and self-care techniques for pain control on TMD, and followed up for 2 weeks. After this period, those who still present pain score over 4 in a visual analog scale (VAS) will be included in the study. Participants will be randomly assigned to 4 treatment groups: G1 = placebo (SHAM); G2 = PBMT with red laser (660 nm, 0.034 cm2, 88 J/cm2, 100 mW, 3 J/point); G3 = PBMT with infrared laser (808 nm, 0.034 cm2, 88 J/cm2, 100 mW, 3 J/point); and G4 = PBMT with red and infrared laser alternated between sessions. The treatment consists of 8 sessions, 2 times a week. The effect of the proposed therapies will be measured by: pain reduction in VAS; pressure pain threshold on TMJ, masseter and temporal muscles; and the amplitude of mandibular movements (opening, protrusion, and right and left lateral movements). The data will be collected at the following times: initial (T1), after the 1st treatment session (T2), at the end of treatment (T3), and 30 days after the last PBMT session (T4). For statistical analysis will be used 2-way repeated measures analysis of variance test, complemented by a post hoc Tukey test (P < .05).
关键词： pain pressure threshold,multiple wavelengths,temporomandibular disorder,low-level laser therapy,orofacial pain,phototherapy,mandibular function,counseling
更新于2025-09-19 17:13:59
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Spontaneous and Dramatic Improvements in Open Bite Deformity Secondary to Large Maxillofacial Venous Malformation With Macroglossia After Sclerotherapy and Laser Therapy
摘要： Large maxillofacial venous malformation (VM) lesions can affect the craniofacial skeleton, causing occlusal and craniofacial deformity. Few studies have discussed the management of these skeletal disorders. It is unclear whether orthodontic treatment and orthognathic surgery are necessary after such a VM lesion has been significantly reduced. Methods: A 13-year-old boy with a large, extensive maxillofacial VM lesion, severe facial asymmetry, macroglossia, and lower hypertrophy visited our department in 2010. He received more than 100 sclerotherapy treatments and 20 laser treatments in the past 8 years. Results: The patient’s cosmetic disfigurement greatly improved, and the VM lesion diminished by more than 80%. Changes in the bite and craniofacial skeleton progressed from ‘‘normal’’ to ‘‘open bite with skeletal deformity’’ and finally to ‘‘spontaneously close to normal’’. Conclusions: During the progression of VM, removal of the aggravation of open bite pathogenic factors can inhibit deformity and promote the spontaneous improvement, thereby circumventing the need for complicated osteotomy, orthodontic intervention and/or orthognathic surgery.
关键词： skeletal deformity,Laser therapy,open bite deformity,venous malformation,sclerotherapy,macroglossia
更新于2025-09-19 17:13:59
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Laser-Assisted Orthodontic Tooth Movement in Saudi Population: A Prospective Clinical Intervention of Low-Level Laser Therapy in the 1st Week of Pain Perception in Four Treatment Modalities
摘要： Background. This ?rst-in-human study in Saudi orthodontic patients has evaluated the role of low-level laser therapy (LLLT) in pain perception (PP). The outcome of single application of LLLT with 4 di?erent treatment modalities (TM) on PP are evaluated following orthodontic bracket bonding on maxilla. Materials and Methods. A prospective clinical intervention with imple- mentation of parallel technique in each group, 32 orthodontic patients with ectopic canine requiring ?xed orthodontic appliance were enrolled and randomly allocated to the 4 groups: LLLT + self-ligating (SL) bracket, LLLT + conventional (Conv.) bracket, non-LLLT + SL bracket, and non-LLLT + Conv. bracket. Orthodontic bracket bonding from 1st molar to 1st molar and superelastic 0.012 inch NiTi were applied for the maxilla. For each patient, maxillary 1st molar to molar received a single application of LLLT using a 940 nm Ga-Al-As laser device on 5 di?erent points labially/buccally and palatally. Main outcome measure was the degree of PP score during the 1st week of orthodontic tooth movement (OTM) after 4 hours, 24 hours, 3 days, and 7 days of both LLLT and non-LLLT treatment applications. A questionnaire with an 11-point numeric rating scale (NRS) was used for PP. Results. Mean ± SD of PP in the LLLT + SL group was 3.33 ± 1.4, 3.58 ± 1.06, 2.31 ± 0.67, and 1.89 ± 0.54 in 4 hours, 24 hours, 3 days, and 7 days, respectively. Compared to all 4 TM groups, LLLT groups showed better PP. More statistically signi?cant di?erences were found in LLLT groups. No harms were encountered. Limitations. The intervention provider and the patient were not blinded to the intervention. Conclusion. The LLLT + SL group revealed signi?cantly promising bene?ts on PP during OTM.
关键词： low-level laser therapy,self-ligating brackets,pain perception,conventional brackets,orthodontic tooth movement
更新于2025-09-19 17:13:59
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The Endovenous Laser Therapy for the Management of Varicose Veins
摘要： Varicose veins of the lower limb are common condition affecting majority of people worldwide and has great effect on quality of life. The definitive therapy being surgery with stripping of the veins which is associated with surgical complications, prolong recovery time and significant recurrence. Endovenous laser therapy (EVLT) is a minimally invasive procedure which is widely used for the treatment of varicose veins with excellent results. Objective: To evaluate the safety and efficacy of EVLT for the management of varicose veins. Methodology: This was a prospective study of 40 patients who underwent endovenous laser therapy at the affiliated hospital of Inner Mongolia University for the Nationalities from October 2016 to September 2017. All patients with primary symptomatic varicose veins with sapheno-femoral incompetence or great saphenous vein (GSV) reflux were included in the study. The patient's information and data were recorded during the hospital stay in the proforma for EVLT with the informed consent. The variables used were mean operating time, intra-operative blood loss, duration of hospital stay, return to normal activity, complications and the recanalization. Following discharge, the patients were followed up to six months. Results: Forty patients with unilateral varicose veins were treated with EVLT. There were 24 female and 16 male with mean age of 52 yrs and the majority of patients having symptoms for more than five years. The mean operative time and intra-operative blood loss were 80 minutes and 52 ml respectively. The mean duration of hospital stay was 2.5 days with 90% patients returning to the normal activity in 10 days. Swelling and induraions were the most common complication in 10 patients followed by hypoesthesia in 8, ecchymosis in 7 and skin burn in 4 patients. Conclusion: EVLT seems to be safe and effective minimally invasive procedure with excellent clinical outcome in terms of lower postoperative pain, early return to normal activities and fewer complications. However large sample size with long follow up study should be conducted for evaluating long term benefits.
关键词： varicose veins,great saphenous vein reflux,Endovenous laser therapy
更新于2025-09-19 17:13:59
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Efficacy of low-level laser therapy on management of Bella??s palsy: a systematic review
摘要： The aim of this study is to evaluate the efficacy of low-level laser therapy (LLLT) in patients with Bell’s palsy (BP) through a systematic review method. We systematically searched international databases including PubMed, Scopus, and Web of Science to find eligible articles without language limitation. All relevant randomized controlled trials (RCTs) that compared the efficacy of the LLLT with placebo laser, exercise, massage, or no intervention on BP patients were included. Four studies (out of 259) had met our inclusion criteria involving 171 patients and were entered to the systematic review. Full texts of the selected studies were retrieved and critically appraised using Physiotherapy Evidence Database (PEDro) scale. The patients of all trials were in sub-acute (less than 1 week) stage. Both of LLLT and control groups showed significant improvement after trials. Two authors reported significant differences between the groups after 6 weeks of laser application (830 nm, 100 mW). In converse, two other authors did not identify any effectiveness following 4 weeks and 15 days of LLLT application with 670 and 830 nm wavelength, sequentially. There is clear lack of information lead to get and evidence-based suggestion for the LLLT application on Bells’ palsy; however, the LLLT irradiation with 830 nm and 100 mW power for a period of 6 weeks might be beneficial on recovery for the patients with sub-acute Bell’s palsy. There were no reported adverse effects during treatment and/or follow-up sessions.
关键词： Physiotherapy,Bell’s palsy,Low-level laser therapy,Facial palsy
更新于2025-09-19 17:13:59
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The Protozoan, <i>Paramecium primaurelia</i> , as a Non-sentient Model to Test Laser Light Irradiation: The Effects of an 808nm Infrared Laser Diode on Cellular Respiration
摘要： Photobiomodulation (PBM) has been used in clinical practice for more than 40 years. Unfortunately, conflicting literature has led to the labelling of PBM as a complementary or alternative medicine approach. However, past and ongoing clinical and research studies by reputable investigators have re-established the merits of PBM as a genuine medical therapy, and the technique has, in the last decade, seen an exponential increase in the numbers of clinical instruments available, and their applications. This resurgence has led to a clear need for appropriate experimental models to test the burgeoning laser technology being developed for medical applications. In this context, an ethical model that employs the protozoan, Paramecium primaurelia, is proposed. We studied the possibility of using the measure of oxygen consumption to test PBM by irradiation with an infrared or near-infrared laser. The results show that an 808nm infrared laser diode (1W; 64J/cm2) affects cellular respiration in P. primaurelia, inducing, in the irradiated cells, a significantly (p < 0.05) increased oxygen consumption of about 40%. Our findings indicate that Paramecium can be an excellent tool in biological assays involving infrared and near-infrared PBM, as it combines the advantages of in vivo results with the practicality of in vitro testing. This test represents a fast, inexpensive and straightforward assay, which offers an alternative to both traditional in vivo testing and more-expensive mammalian cellular cultures.
关键词： laser irradiation,mitochondria,low level laser therapy,high level laser therapy,photobiostimulation,laser phototherapy
更新于2025-09-16 10:30:52
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The 808?nm and 980?nm infrared laser irradiation affects spore germination and stored calcium homeostasis: A comparative study using delivery hand-pieces with standard (Gaussian) or flat-top profile
摘要： Photobiomodulation relies on the transfer of energy from incident photons to a cell photoacceptor. For many years the concept of photobiomodulation and its outcome has been based upon a belief that the sole receptor within the cell was the mitochondrion. Recently, it has become apparent that there are other photoacceptors operating in different regions of the electromagnetic spectrum. Alternative photoacceptors would appear to be water and mechanisms regulating calcium homeostasis, despite a direct effect of laser photonic energy on intracellular calcium concentration outwith mitochondrial activity or influence, have not been clearly demonstrated. Therefore, to increase the knowledge of intracellular?calcium and laser photon interaction, as well as to demonstrate differences in irradiation profiles with modern hand-pieces, we tested and compared the photobiomodulatory effect of 808 nm and 980 nm diode laser light by low- and higher-energy (60s, 100 mW/cm2, 100 mW/cm2, 500 mW/cm2, 1000 mW/cm2, 1500 mW/cm2, 2000 mW/cm2) irradiated with a “standard” (Gaussian fluence distribution) hand-piece or with a “flat-top” (uniform fluence) hand-piece. For this purpose, we used the eukaryote unicellular-model Dictyostelium discoideum. The 808 nm and 980 nm infrared laser light, at the energy tested directly affect the stored Ca2+ homeostasis, independent of the mitochondrial respiratory chain activities. From an organism perspective, the effect on Ca2+-dependent signal transduction as the regulator of spore germination in Dictyostelium, demonstrates how a cell can respond quickly to the correct laser photonic stimulus through a different cellular pathway than the known light-chromophore(mitochondria) interaction. Additionally, both hand-piece designs tested were able to photobiomodulate the D. discoideum cell; however, the hand-piece with a flat-top profile, through uniform fluence levels allows more effective and reproducible effects.
关键词： Mitochondria activities,Laser therapy,Photobiomodulation,Low-level laser therapy,Intracellular calcium concentration
更新于2025-09-16 10:30:52
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Synergistic effects of vacuum therapy and laser therapy on physical rehabilitation
摘要： [Purpose] This study aims to evaluate the synergistic effects of laser therapy and vacuum therapy in the rehabilitation of some disorders of the osteomuscular articular system (shoulder bursitis, low back pain, hip dysfunction after long-term impact of femoral endoprosthesis). [Participants and Methods] Three case reports were described. A vacuum laser system was used, which is a device that contains 1 handpiece with 3 red lasers (660 nm) and 3 infrared lasers (808 nm). This device contains 6 laser beams that are arranged around the vacuum chamber bore which generate negative pressure. Two weekly sessions were held, totalling 10 treatment sessions. Active goniometry was performed to assess range of motion (ROM) of the shoulder, lumbar spine and hip, and visual analogue scale (VAS) was used to evaluate pain in the pre and posttreatment period. [Results] There was a pain reduction and an increase in ROM in the different clinical cases. [Conclusion] Potentiating laser therapy through suctioning during the rehabilitation process leads to pain relief and increased functionality.
关键词： Vacuum therapy,Physical rehabilitation,Laser therapy
更新于2025-09-16 10:30:52
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Gutartige Lidtumoren: CO2-Laser statt Skalpell
摘要： Gutartige Tumoren am Augenlid werden zumeist chirurgisch entfernt. Dies erfolgt so wenig invasisv und so kosmetisch wie m?glich; dennoch gibt es Patienten, denen man z. B. aufgrund ihrer allgemeinen Verfassung oder ihrer Vorbehalte eine Alternative anbieten m?chte. Dies kann z. B. eine Laserbehandlung sein: Eine retrospektive klinische Studie analysierte die Ergebnisse einer Tumorexzision mit dem ultragepulsten CO2-Laser.
关键词： surgical alternative,laser therapy,benign eyelid tumors,CO2-Laser
更新于2025-09-16 10:30:52
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Efficacy of low-level laser therapy on pain and disability in knee osteoarthritis: systematic review and meta-analysis of randomised placebo-controlled trials
摘要： Objectives Low-level laser therapy (LLLT) is not recommended in major knee osteoarthritis (KOA) treatment guidelines. We investigated whether a LLLT dose–response relationship exists in KOA. Design Systematic review and meta-analysis. Data sources Eligible articles were identified through PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Physiotherapy Evidence Database and Cochrane Central Register of Controlled Trials on 18 February 2019, reference lists, a book, citations and experts in the field. Eligibility criteria for selecting studies We solely included randomised placebo-controlled trials involving participants with KOA according to the American College of Rheumatology and/or Kellgren/Lawrence criteria, in which LLLT was applied to participants’ knee(s). There were no language restrictions. Data extraction and synthesis The included trials were synthesised with random effects meta-analyses and subgrouped by dose using the World Association for Laser Therapy treatment recommendations. Cochrane’s risk-of- bias tool was used. results 22 trials (n=1063) were meta-analysed. Risk of bias was insignificant. Overall, pain was significantly reduced by LLLT compared with placebo at the end of therapy (14.23 mm Visual Analogue Scale (VAS; 95% CI 7.31 to 21.14)) and during follow-ups 1–12 weeks later (15.92 mm VAS (95% CI 6.47 to 25.37)). The subgroup analysis revealed that pain was significantly reduced by the recommended LLLT doses compared with placebo at the end of therapy (18.71 mm (95% CI 9.42 to 27.99)) and during follow-ups 2–12 weeks after the end of therapy (23.23 mm VAS (95% CI 10.60 to 35.86)). The pain reduction from the recommended LLLT doses peaked during follow-ups 2–4 weeks after the end of therapy (31.87 mm VAS significantly beyond placebo (95% CI 18.18 to 45.56)). Disability was also statistically significantly reduced by LLLT. No adverse events were reported. Conclusion LLLT reduces pain and disability in KOA at 4–8 J with 785–860 nm wavelength and at 1–3 J with 904 nm wavelength per treatment spot. PrOSPErO registration number CRD42016035587.
关键词： disability,low-level laser therapy,knee osteoarthritis,meta-analysis,pain
更新于2025-09-16 10:30:52