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Effects of High-Intensity Laser Therapy on Pain Sensitivity and Motor Performance in Patients with Thumb Carpometacarpal Joint Osteoarthritis: A Randomized Controlled Trial
摘要： Objective. To examine the effects of high-intensity laser therapy (HILT) on pain sensitivity and motor performance in patients with thumb carpometacarpal (CMC) osteoarthritis (OA). Design. Prospective, triple-blinded, randomized, placebo-controlled trial. Setting. Private practice, Malaga, Spain. Subjects. Forty-three patients (mean 6 SD age ? 71 6 12 years) with a diagnosis of thumb CMC OA grade 1–2 were randomized to the control group (N ? 21) or experimental group (N ? 22). Methods. The experimental group (ExpG) received high-intensity laser therapy (HILT), and the control group (ConG) received a placebo treatment. The outcome measures were pain intensity (visual analog scale) and key pinch strength measurements (dynamometer). All outcome measures were collected at baseline, immediately following the intervention, at four weeks, and at 12 weeks following the intervention. Results. Analysis of variance revealed a group (cid:2) time interaction (F ? 40.8, P < 0.001) for pain intensity, with those patients receiving LT experiencing a greater reduction in pain compared with those receiving placebo therapy at the end of the intervention (P < 0.001), as well as at 12 weeks after the intervention. Although mean values in the ExpG were higher than in the ConG for key pinch at assessment, these differences were not statistically significant. Conclusions. HILT effectively diminishes pain intensity when used as an isolated treatment for patients with thumb CMC OA, but the effect of treatment decreases after 12 weeks.
关键词： Laser Therapy,Osteoarthritis,Thumb,Pain
更新于2025-09-12 10:27:22
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Safety of Combination Laser or Intense Pulsed Light Therapies and Doxycycline for the Treatment of Rosacea
摘要： BACKGROUND Current treatment options for rosacea include topical agents, oral therapies, phototherapy using lasers, or intense pulsed light (IPL). Combination therapy for rosacea often yields better results than monotherapy. The safety of laser/light treatments in combination with systemic doxycycline has been questioned because of the theoretical risk of photosensitivity. OBJECTIVE The purpose of this study was to assess the incidence of phototoxicity or photosensitivity in rosacea patients receiving concomitant laser or light treatments and systemic doxycycline. METHODS Treatment records of 36 patients receiving laser/light treatments while also being treated with standard dose or anti-inflammatory dose of doxycycline were retrospectively reviewed. RESULTS No adverse reactions related to doxycycline combined with laser/light therapy were reported. Specifically, no photosensitivity or sensitivity to wavelengths in the pulsed dye laser (PDL), or IPL range was observed in this cohort. All patients achieved some degree of clearance. CONCLUSION The results of this retrospective study demonstrate that doxycycline used in conjunction with laser or nonlaser light therapy is a valid combination therapy for improving signs and symptoms of rosacea. No photosensitivity reactions were observed to commonly used IPL or PDL devices.
关键词： rosacea,intense pulsed light,doxycycline,photosensitivity,laser therapy
更新于2025-09-12 10:27:22
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Vascular and Pigmented Lesions of Phacomatosis Pigmentovascularis Treated With a Combination of Long-Pulsed, Q-Switched Laser, and Picosecond Lasers
摘要： Phacomatosis pigmentovascularis (PPV) is a rare congenital condition characterized by the coexistence of port-wine stains (PWS) and various melanocytic lesions. Treatment should be considered, given the often extensive lesions and social impact. Of the approximate 250 reported cases of PPV, only 5 cases discuss treatment options. Laser therapy is widely used and successful in treating the individual lesions often seen in PPV. However, the collision of these red and brown pigments of different depths in the dermis, often on a background of darker skin, makes treatment of these lesions challenging. This case, and a review of 4 PPV treatment cases, highlights the success of combination laser treatment and addresses factors including age and choice of anesthesia that will optimize results.
关键词： melanocytic lesions,Phacomatosis pigmentovascularis,port-wine stains,PPV,laser therapy
更新于2025-09-12 10:27:22
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Efficacy of laser therapy for exercise-induced fatigue
摘要： Background: Laser therapy is widely used for exercise-induced fatigue, while the effect among different studies remains controversial. The present study was to summary available randomized controlled trials (RCTs) to evaluate the effect of laser therapy in subjects with exercise-induced fatigue. Methods: PubMed, Embase, and Cochrane Library were searched to identify the potential RCTs from inception to October 2017. The weighted mean difference (WMD) with 95% confidence intervals (CIs) was calculated using a random-effects model. Results: Twenty RCTs involving a total of 394 individuals were included in final analysis. No significant differences were observed between the laser therapy and control for the outcomes of lactate (WMD: (cid:1)0.19; 95%CI: (cid:1)0.52 to 0.13; P = .244), repetitions (WMD: 4.44; 95%CI: (cid:1)1.43 to 10.32; P = .138), work load (WMD: 3.38; 95%CI: (cid:1)1.15 to 7.91; P = .144), time taken to perform the exercise tests (WMD: 4.42; 95%CI: (cid:1)2.33 to 11.17; P = .199), creatine kinase (WMD: (cid:1)41.80; 95%CI: (cid:1)168.78 to 85.17; P = .519), maximum voluntary contraction (WMD: 23.83; 95%CI: (cid:1)7.41 to 55.07; P = .135), mean peak forces (WMD: 2.87; 95%CI: (cid:1)1.01 to 6.76; P = = .147), and visual analog scale (VAS) (WMD: (cid:1)1.91; 95%CI: (cid:1)42.89 to 39.08; P = = .927). The results of sensitivity analysis suggested that laser therapy might play an important role on the levels of lactate (WMD: (cid:1)0.30; 95%CI: (cid:1)0.59 to (cid:1)0.01; P = = .040), maximum voluntary contraction (WMD: 33.54; 95%CI: 1.95 to 65.12; P = = .037), and VAS (WMD: (cid:1)21.00; 95%CI: (cid:1)40.78 to (cid:1)1.22; P = = .037). The results of subgroup analyses indicated no significant differences between the laser therapy and placebo for lactate and repetitions when stratified by study design, mean age, gender, and study quality. Conclusions: The findings of this meta-analysis did not indicate any significant differences between the laser therapy and placebo.
关键词： meta-analysis,laser therapy,exercise-induced fatigue
更新于2025-09-12 10:27:22
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Evaluation of the Effects of Low-Level Laser Therapy on Diabetic Bone Healing
摘要： The aim of the present study was to evaluate the effects of low-level laser therapy (LLLT) and biphasic alloplastic bone graft material on diabetic bone healing. Induction of diabetes was performed in 14 male Sprague-Dawley rats by intraperitoneal injection of a 50 mg/kg dose of streptozotocin. Two bilaterally symmetrical non-critical-sized bone defects were created in the parietal bones in each rat. Right defects were filled with biphasic alloplastic bone graft. Rats were randomly divided into 2 groups, with 1 group receiving 10 sessions of LLLT (GaAlAs, 78.5 J/cm2, 100mW, 0.028 cm2 beam). The LLLT was started immediately after surgery and once every 3 days during postoperative period. At the end of treatment period, new bone formation and osteoblast density were determined using histomorphometry. Empty (control), graft-filled, LLLT-treated and both graft-filled and LLLT-treated bone defects were compared. New bone formation was higher in the graft treatment samples compared with the control (P ? 0.009) and laser samples (P ? 0.029). In addition, graft–laser combination treatment samples revealed higher bone formation than control (P ? 0.008) and laser (P ? 0.026) samples. Osteoblast density was significantly higher in the laser treatment (P <0.001), graft treatment (P ? 0.001) and graft–laser combination treatment (P <0.001) samples than control samples. In addition, significantly higher osteoblast density was observed in the graft-laser combination treatment samples compared to the graft treatment samples (P ? 0.005). The LLLT was effective to stimulate osteoblastogenesis but failed to increase bone formation. Graft augmentation for treatment of bone defects seems essential for proper bone healing in diabetes, regeneration may be supported by the LLLT to enhance osteoblastogenesis.
关键词： Bone healing,diabetes,low-level laser therapy
更新于2025-09-12 10:27:22
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The outcome of using different surgical modalities and laser therapy in the treatment of small‐ and medium‐sized congenital melanocytic nevi: a systematic review
摘要： Objectives The purpose of this study is to review the published articles regarding different surgical modalities including laser therapy in the treatment of congenital melanocytic nevi (CMN). Methods A systematic review was done using several databases including PubMed, Ovid Medline, Google Scholar, and Medline to search for articles related to surgical excisions and different treatment modalities of CMN. Results Fourteen studies were included according to the inclusion and exclusion criteria. The results have shown that the Q-switched ruby laser therapy was the most commonly used laser therapy to treat CMN. Overall, using laser therapy had positive outcomes in CMN treatment. However, limited knowledge was available regarding patient satisfaction with the outcomes of laser therapy. Conclusion We concluded that the most acceptable surgical choice was using excision with tissue expanders. Laser-intense pulsed light (IPL) alone and in combination with Erbium:yttrium-aluminum-garnet (Er:YAG) has a risk of recurrence. Combination of types of the laser is more effective than a single one.
关键词： Congenital melanocytic nevi,Surgical Modalities,Laser Therapy,Treatment,Outcome
更新于2025-09-12 10:27:22
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Current surgical techniques of enucleation in holmium laser enucleation of the prostate
摘要： Holmium laser enucleation of the prostate (HoLEP) has been accepted as the most efficient method of transurethral surgery for benign prostatic hyperplasia. The originally developed three-lobe technique has popularized this surgery; this method is based on three longitudinal incisions, by which the median lobe is removed, and subsequently, both lateral lobes are enucleated. To maintain a consistent surgical plane and to minimize sphincteric damage, the traditional three-lobe technique is continuously being refined and evolving. A few modifications of the original technique have been developed, and several en bloc enucleation methods have been introduced. However, more clinical evidence is required to show the superiority of newer techniques over the original three-lobe technique in terms of efficacy and long-term side effects. To date, none of the newer techniques have been accepted as a standard technique for HoLEP.
关键词： Enucleation,Laser therapy,Prostatic hyperplasia,Transurethral resection of prostate,Holmium
更新于2025-09-12 10:27:22
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Utilization of Laser Therapy During Pregnancy
摘要： BACKGROUND Due to concerns regarding maternal and fetal safety and the absence of evidence to the contrary, laser treatment during pregnancy has traditionally been limited to situations of absolute necessity. OBJECTIVE This review seeks to examine the available evidence to determine the safety of laser therapy during pregnancy. METHODS Medical databases were searched for relevant reports from all specialties regarding the use of lasers during pregnancy from 1960 to 2017. A legal case review was also performed. RESULTS Twenty-two publications in the literature reported the use of various laser wavelengths in 380 pregnant women during all trimesters. Other than 1 case of premature rupture of membranes questionably related to the laser treatment, there were no cases of maternal or fetal morbidity or mortality, premature labor, or identi?able fetal stress. CONCLUSION The available evidence, limited to low evidence level case reports and series, indicates cutaneous laser treatment during pregnancy is safe for both mother and fetus. Furthermore, laser physics and optics dictate there should theoretically be no risk of fetal laser exposure from commonly used cutaneous lasers.
关键词： pregnancy,safety,fetal effects,maternal effects,laser therapy
更新于2025-09-12 10:27:22
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Comparison of the efficiency of alveolar decortication and low level laser therapy on orthodontic tooth movement and alveolar metabolism in rats
摘要： Background/purpose: Reducing orthodontic treatment duration has many advantages for both clinicians and patients. This study was designed to compare the effects of alveolar decortication and low level laser therapy methods on tooth movement rate and alveolar bone metabolism. Materials and methods: A total of 42 Wistar albino rats were divided into three main groups as: Alveolar decortication (AD), low level laser therapy (LLLT) and only orthodontic force (F). The groups were evaluated at 7 and 14 day time points. Tooth movement rates were calculated by measuring the space between the contact points of the first and second molars. Comparisons regarding the alveolar bone metabolism were accomplished by evaluating osteoclast counts and RANKL - OPG expressions. Results: The rate of tooth movement, at all time points, was significantly higher for the AD group than the other groups and was significantly higher in the LLLT group than the F group. At both time points, the RANKL and OPG expression in the AD group was significantly higher than the other groups and these parameters in the LLLT group was significantly higher than the F group. The osteoclast count values in the AD and LLLT groups were significantly higher than the F group and there were no significant differences between these two groups at all time points. Conclusion: This study shows that, to be more effective at AD, both AD and LLLT therapy significantly increases the level of tooth movement in the early period through their stimulating effects on the alveolar bone metabolism.
关键词： Tooth movement,Low level laser therapy,Alveolar decortication,RANKL-OPG
更新于2025-09-12 10:27:22
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Photobiostimulation activity of different low-level laser dosage on masticatory muscles and temporomandibular joint in an induced arthritis rat model
摘要： This study aimed to investigate the anti-inflammatory effects of different dosage of low-level laser therapy (LLLT) in an experimental model of temporomandibular joint (TMJ) arthritis. One hundred male Wistar rats were used and divided into the following groups: CG, control group; AG, animals group with left TMJ arthritis induced by intra-articular injection of Complete Freund’s adjuvant - CFA; LG5, LG10 and LG20 - animals with arthritis and treated with LLLT at doses 5, 10, and 20 J/cm2, respectively. Morphological analysis was performed by TMJ histological sections stained with hematoxylin-eosin (HE), picrosirius (PSR), and toluidine blue (TB), as well as histomorphometric evaluation of cartilage, articular disc, and masticatory muscles. The amount of feed consumed within 3 weeks was evaluated, and biochemical analysis of TMJ tissues included measurement of sulfated glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) 2 and 9 zymography, and ELISA for cytokines IL-6, TNF-α, and IL-1β. Only the 20 J/cm2 dose promoted higher feed intake compared to AG. On the other hand, all LLLT doses promoted better organization of articular disc collagen fibers, greater number of proteoglycans in articular cartilage, increased area and diameter of left lateral pterygoid fibers, reduced latent and active MMP 9 and 2 activity, and lower IL-1β concentration compared to AG. Considering the study limitations, it was observed that LLLT treatments were effective in protecting and tissue cleansing joint structures, accelerating tissue repair, especially at lower doses.
关键词： Arthritis,Inflammation,Low-level laser therapy,Masticatory muscles,Temporomandibular joint disorders
更新于2025-09-12 10:27:22