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Investigating energy deposition in glandular tissues for mammography using multiscale Monte Carlo simulations
摘要： Purpose: To investigate energy deposition in glandular tissues of the breast on macro- and microscopic length scales in the context of mammography. Methods: Multiscale mammography models of breasts are developed, which include segmented, voxelized macroscopic tissue structure as well as nine regions of interest (ROIs) embedded throughout the breast tissue containing explicitly-modelled cells. Using a 30 kVp Mo/Mo spectrum, Monte Carlo (MC) techniques are used to calculate dose to mm voxels containing glandular and/or adipose tissues, as well as energy deposition on cellular length scales. ROIs consist of at least 1000 mammary epithelial cells and 200 adipocytes; specific energy (energy imparted per unit mass; stochastic analogue of the absorbed dose) is calculated within mammary epithelial cell nuclei. Results: Macroscopic dose distributions within segmented breast tissue demonstrate considerable variation in energy deposition depending on depth and tissue structure. Doses to voxels containing glandular tissue vary between 0.1 and 4 times the mean glandular dose (MGD, averaged over the entire breast). Considering microscopic length scales, mean specific energies for mammary epithelial cell nuclei are 30% higher than the corresponding glandular voxel dose. Additionally, due to the stochastic nature of radiation, there is considerable variation in energy deposition throughout a cell population within a ROI: for a typical glandular voxel dose of 4 mGy, the standard deviation of the specific energy for mammary epithelial cell nuclei is 85% relative to the mean. Thus, for a glandular voxel dose of 4 mGy at the centre of the breast, corresponding mammary epithelial cell nuclei will receive specific energies up to 9 mGy (considering the upper end of the 1σ standard deviation of the specific energy), while a ROI located 2 cm closer to the radiation source will receive specific energies up to 40 mGy. Energy deposition within mammary epithelial cell nuclei is sensitive to cell model details including cellular elemental compositions and nucleus size, underlining the importance of realistic cellular models. Conclusions: There is considerable variation in energy deposition on both macro- and microscopic length scales for mammography, with glandular voxel doses and corresponding cell nuclei specific energies many times higher than the MGD in parts of the breast. These results should be considered for radiation-induced cancer risk evaluation in mammography which has traditionally focused on a single metric such as the MGD.
关键词： microdosimetry,cellular dosimetry,breast dosimetry,Mammography,Monte Carlo
更新于2025-09-19 17:15:36
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Calculation of kQ factors for Farmer-type ionization chambers following the recent recommendations on new key dosimetry data
摘要： Purpose: To calculate by Monte Carlo simulations kQ factors for Farmer-type ionization chambers in megavoltage photon beams using the new key dosimetry data recommended by the International Commission on Radiation Units and Measurements (ICRU) Report 90. Methods: Monte Carlo calculations were performed with the EGSnrc code system using both the ICRU 90 and the ICRU 37 data. Farmer-type ionization chambers with graphite and plastic walls and with graphite wall and a plastic waterproofing sleeve were considered (Nuclear Enterprise NE 2571, IBA FC65-G and FC65-P). kQ factors were calculated for photon beams in the range 6–25 MV using phase-space files as input radiation sources. The photon beam qualities in terms of TPR20,10 and %dd(10)x were established by simulating the depth-dose curves in water. Absorbed doses to the air cavity and to water were calculated using the egs_chamber user code with a target statistical uncertainty below 0.1%. Results: The update of key dosimetry data according to the ICRU report 90 had an impact of ?0.2% in the absorbed dose to water and up to 0.5% in the absorbed dose to the air cavity. Nevertheless, changes partially offset each other when entering in kQ as ratio, and the final impact on the kQ values was below 0.3%. Conclusions: The calculated values of kQ tend to be lower than the current values in the IAEA TRS-398 protocol with differences up to about 0.5%. A slightly better agreement (within 0.3%) is observed with the Monte-Carlo calculated values provided by the addendum to the AAPM’s TG-51 protocol.
关键词： Monte-Carlo calculated kQ,Beam quality correction factor,kQ,Radiotherapy dosimetry,ICRU 90
更新于2025-09-19 17:15:36
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High-speed light source depth estimation using spatially-resolved diffuse imaging
摘要： We describe a system for high-speed depth estimation of a light source embedded in a scattering medium. A polynomial model estimates source depth from the spatially-resolved, diffuse reflectance profile measured with a fibre optic probe on the surface of a scattering medium. A dataset of Monte Carlo reflectance profiles is generated over a range of typical optical properties and the model is fit to the simulated reflectance at four detector locations. The model accounts for a source depth up to 15 mm. Cross-validation using the Monte Carlo dataset produced a root mean square error of 0.12 mm. Experimental reflectance data is acquired with the detector probe, which consists of four optical fibres mounted in a black acetal plastic disk. The optical fibres are coupled into avalanche photodiodes for high-speed acquisition of the reflectance profile. When applied to measurements from a tissue-mimicking phantom with an embedded light source, the polynomial model generates depth estimates within 2 mm of the true depth, up to a source depth of 15 mm.
关键词： source location,Monte Carlo simulation,tissue optics,turbid media,diffuse reflectance
更新于2025-09-19 17:15:36
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A stochastic SPICE model for superconducting nanowire single photon detectors and other nanowire devices
摘要： Superconducting nanowire devices such as the superconducting nanowire single photon detector (SNSPD) or nanocryotron (nTron) have a time-dependent stochasticity that depends on the current flowing through them. When modeling complex circuits made of several such devices (for instance, an array of SNSPDs), the ability to include this randomness can be important for predicting unwanted effects and interactions within the circuit. We present a modification of the model described by Berggren et. al. that allows for the inclusion of this stochasticity into the nanowire device model. We then verify the model against experiment using a tungsten silicide SNSPD, and show that the modified model replicates the stochasticity of the physical device.
关键词： SNSPD,SPICE model,Monte Carlo analysis,superconducting nanowire,nTron,stochasticity
更新于2025-09-19 17:15:36
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Confidence Distance Matrix for outlier identification: A new method to improve the characterizations of surfaces measured by confocal microscopy
摘要： This paper proposes a statistical method for outlier identification for surface measurement data obtained by confocal microscopy. The implemented statistical method is Confidence Distance Matrix (CDM) which were widely used in statistics and many engineering areas, such as signal processing, sensor data fusion, information problems, etc. However, no investigations on identifying outliers in measured surface data using CDM have been found. This paper introduces and simplifies the mathematical model of CDM method. Algorithms for identifying random outliers using Monte Carlo method for uncertainty evaluation and for identifying outliers in a unique measured surface are developed and validated. For validation of the algorithms, a synthetic data SG_3-3 provided by National Institute of Standards and Technology and a data of artificial stochastic surface generated by our own algorithms are implemented. The difference of Sq of the data with outliers is 2.3342% and after deletion of outliers is 0.0037% with reference to the certified value. A type C1 spacing standard with dust dropped is measured and processed using CDM. The difference of Sa decreases from 29.65% to 3.52% after processing outliers with reference to the certified value Ra. An iron surface is measured and processed. Surface slopes and curvatures of the data in the two validations and two experiments are compared. All those parameters, the surface reconstructions, histogram of heights, and QQ plot of the measured surface data versus the data after deletion of outliers indicate our proposed method working well.
关键词： Confidence Distance matrix,outlier detection,areal surface characterization,threshold determination,Imaging Confocal Microscopy,Monte Carlo method
更新于2025-09-19 17:15:36
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A depolarisation lidar-based method for the determination of liquid-cloud microphysical properties
摘要： The fact that polarisation lidars measure a depolarisation signal in liquid clouds due to the occurrence of multiple scattering is well known. The degree of measured depolarisation depends on the lidar characteristics (e.g. wavelength and receiver field of view) as well as the cloud macrophysical (e.g. cloud-base altitude) and microphysical (e.g. effective radius, liquid water content) properties. Efforts seeking to use depolarisation information in a quantitative manner to retrieve cloud properties have been undertaken with, arguably, limited practical success. In this work we present a retrieval procedure applicable to clouds with (quasi-)linear liquid water content (LWC) profiles and (quasi-)constant cloud-droplet number density in the cloud-base region. Thus limiting the applicability of the procedure allows us to reduce the cloud variables to two parameters (namely the derivative of the liquid water content with height and the extinction at a fixed distance above cloud base). This simplification, in turn, allows us to employ a fast and robust optimal-estimation inversion using pre-computed look-up tables produced using extensive lidar Monte Carlo (MC) multiple-scattering simulations. In this paper, we describe the theory behind the inversion procedure and successfully apply it to simulated observations based on large-eddy simulation (LES) model output. The inversion procedure is then applied to actual depolarisation lidar data corresponding to a range of cases taken from the Cabauw measurement site in the central Netherlands. The lidar results were then used to predict the corresponding cloud-base region radar reflectivities. In non-drizzling condition, it was found that the lidar inversion results can be used to predict the observed radar reflectivities with an accuracy within the radar calibration uncertainty (2–3 dBZ). This result strongly supports the accuracy of the lidar inversion results. Results of a comparison between ground-based aerosol number concentration and lidar-derived cloud-droplet number densities are also presented and discussed. The observed relationship between the two quantities is seen to be consistent with the results of previous studies based on aircraft-based in situ measurements.
关键词： Monte Carlo simulations,cloud-base region,aerosol-cloud interactions,retrieval procedure,depolarisation lidar,liquid-cloud microphysical properties,multiple scattering,radar reflectivity
更新于2025-09-19 17:15:36
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[IEEE 2019 IEEE 46th Photovoltaic Specialists Conference (PVSC) - Chicago, IL, USA (2019.6.16-2019.6.21)] 2019 IEEE 46th Photovoltaic Specialists Conference (PVSC) - Electron Trapping Enhancement in Gold and Silver Modified ZnO Nanocomposites as Photoanodes for Dye-Sensitized Solar Cells
摘要： In this paper, Monte Carlo tree search (MCTS) is introduced for controlling the Pac-Man character in the real-time game Ms Pac-Man. MCTS is used to find an optimal path for an agent at each turn, determining the move to make based on the results of numerous randomized simulations. Several enhancements are introduced in order to adapt MCTS to the real-time domain. Ms Pac-Man is an arcade game, in which the protagonist has several goals but no conclusive terminal state. Unlike games such as Chess or Go there is no state in which the player wins the game. Instead, the game has two subgoals, 1) surviving and 2) scoring as many points as possible. Decisions must be made in a strict time constraint of 40 ms. The Pac-Man agent has to compete with a range of different ghost teams, hence limited assumptions can be made about their behavior. In order to expand the capabilities of existing MCTS agents, four enhancements are discussed: 1) a variable-depth tree; 2) simulation strategies for the ghost team and Pac-Man; 3) including long-term goals in scoring; and 4) reusing the search tree for several moves with a decay factor. The agent described in this paper was entered in both the 2012 World Congress on Computational Intelligence (WCCI’12, Brisbane, Qld., Australia) and the 2012 IEEE Conference on Computational Intelligence and Games (CIG’12, Granada, Spain) Pac-Man Versus Ghost Team competitions, where it achieved second and first places, respectively. In the experiments, we show that using MCTS is a viable technique for the Pac-Man agent. Moreover, the enhancements improve overall performance against four different ghost teams.
关键词： real time,Monte Carlo tree search (MCTS),Pac-Man,Monte Carlo
更新于2025-09-19 17:13:59
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[IEEE 2019 Photonics & Electromagnetics Research Symposium - Fall (PIERS - Fall) - Xiamen, China (2019.12.17-2019.12.20)] 2019 Photonics & Electromagnetics Research Symposium - Fall (PIERS - Fall) - 24 GHz Circular Cavity-backed Slot Antenna Based on Corrugated Substrate Integrated Waveguides
摘要： In this paper, Monte Carlo tree search (MCTS) is introduced for controlling the Pac-Man character in the real-time game Ms Pac-Man. MCTS is used to find an optimal path for an agent at each turn, determining the move to make based on the results of numerous randomized simulations. Several enhancements are introduced in order to adapt MCTS to the real-time domain. Ms Pac-Man is an arcade game, in which the protagonist has several goals but no conclusive terminal state. Unlike games such as Chess or Go there is no state in which the player wins the game. Instead, the game has two subgoals, 1) surviving and 2) scoring as many points as possible. Decisions must be made in a strict time constraint of 40 ms. The Pac-Man agent has to compete with a range of different ghost teams, hence limited assumptions can be made about their behavior. In order to expand the capabilities of existing MCTS agents, four enhancements are discussed: 1) a variable-depth tree; 2) simulation strategies for the ghost team and Pac-Man; 3) including long-term goals in scoring; and 4) reusing the search tree for several moves with a decay factor. The agent described in this paper was entered in both the 2012 World Congress on Computational Intelligence (WCCI’12, Brisbane, Qld., Australia) and the 2012 IEEE Conference on Computational Intelligence and Games (CIG’12, Granada, Spain) Pac-Man Versus Ghost Team competitions, where it achieved second and first places, respectively. In the experiments, we show that using MCTS is a viable technique for the Pac-Man agent. Moreover, the enhancements improve overall performance against four different ghost teams.
关键词： Monte Carlo,real time,Monte Carlo tree search (MCTS),Pac-Man
更新于2025-09-19 17:13:59
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Few-cycle laser driven reaction nanoscopy on aerosolized silica nanoparticles
摘要： Nanoparticles offer unique properties as photocatalysts with large surface areas. Under irradiation with light, the associated near-fields can induce, enhance, and control molecular adsorbate reactions on the nanoscale. So far, however, there is no simple method available to spatially resolve the near-field induced reaction yield on the surface of nanoparticles. Here we close this gap by introducing reaction nanoscopy based on three-dimensional momentum-resolved photoionization. The technique is demonstrated for the spatially selective proton generation in few-cycle laser-induced dissociative ionization of ethanol and water on SiO2 nanoparticles, resolving a pronounced variation across the particle surface. The results are modeled and reproduced qualitatively by electrostatic and quasi-classical mean-field Mie Monte-Carlo (M3C) calculations. Reaction nanoscopy is suited for a wide range of isolated nanosystems and can provide spatially resolved ultrafast reaction dynamics on nanoparticles, clusters, and droplets.
关键词： ethanol,water,SiO2 nanoparticles,photocatalysts,nanoparticles,Mie Monte-Carlo calculations,momentum-resolved photoionization,reaction nanoscopy,near-fields
更新于2025-09-19 17:13:59
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[IEEE 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) - Munich, Germany (2019.6.23-2019.6.27)] 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) - Stable DFB Ridge Laser Diodes at 894nm at R.T. for Cesium Atomic Clocks
摘要： In this paper, we report on an optical tolerance analysis of the submillimeter atmospheric multi-beam limb sounder, STEAMR. Physical optics and ray-tracing methods were used to quantify and separate errors in beam pointing and distortion due to re?ector misalignment and primary re?ector surface deformations. Simulations were performed concurrently with the manufacturing of a multi-beam demonstrator of the relay optical system which shapes and images the beams to their corresponding receiver feed horns. Results from Monte Carlo simulations show that the inserts used for re?ector mounting should be positioned with an overall accuracy better than 100 m ( 1/10 wavelength). Analyses of primary re?ector surface deformations show that a deviation of magnitude 100 m can be tolerable before deployment, whereas the corresponding variations should be less than 30 m during operation. The most sensitive optical elements in terms of misalignments are found near the focal plane. This localized sensitivity is attributed to the off-axis nature of the beams at this location. Post-assembly mechanical measurements of the re?ectors in the demonstrator show that alignment better than 50 m could be obtained.
关键词： Stratosphere–Troposphere Exchange And climate Monitor Radiometer (STEAMR),multi-beam,quasi-optics,submillimeter-wave instruments,Limb viewing,Monte Carlo,tolerance analysis
更新于2025-09-19 17:13:59