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Near-infrared irradiation affects lipid metabolism in neuronal cells, inducing lipid droplets formation
摘要： It is known that lipids play an outstanding role in cellular regulation and their dysfunction has been linked to many diseases. Thus, modulation of lipid metabolism may provide new pathways for disease treatment or prevention. In this work, near infrared (NIR) light was applied to modulate lipid metabolism, and increase intracellular lipid content in rat cortical neurons (RCN). Using label-free CARS microscopy, we have monitored the intracellular lipid content in RCN at a single cell level. A major increase in average level of lipid per cell after treatment with laser diode at 808 nm was found, nonlinearly dependent on the irradiation dose. Moreover, a striking formation of lipid droplets (LDs) in the irradiated RCN was discovered. Further experiments and analysis reveal a strong correlation between NIR light induced generation of reactive oxygen species (ROS), lipids level and LDs formation in RCN. Our findings can contribute to a development of therapeutic approaches for neurological disorders via NIR light control of lipid metabolism in neuronal cells.
关键词： CARS imaging,neuronal cells.,ROS,NIR light,lipids
更新于2025-09-23 15:21:21
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[IEEE 2019 24th Microoptics Conference (MOC) - Toyama, Japan (2019.11.17-2019.11.20)] 2019 24th Microoptics Conference (MOC) - Light-Induced Self-Written Optical Waveguide Fabrication by Near Infrared Continuous Wave Laser Light with Microwatt Power
摘要： We have successfully demonstrated light-induced self-written (LISW) waveguides at a wavelength of 1070 nm and 1310 nm, respectively. Microwatt level photopolymerization threshold value was obtained at both wavelengths. The results show a promising approach for optical interconnection in silicon photonics.
关键词： Photopolymerization,Continuous Wave (CW) laser,Silicon photonics,Near Infrared (NIR),Light-induced self-written (LISW) waveguides
更新于2025-09-23 15:21:01
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Novel phthalocyanine-based micelles/PNIPAM composite hydrogels: spatial/temporal-controlled drug release triggered by NIR laser irradiation
摘要： Near-infrared (NIR) light-responsive hydrogels hold significant potential for biomedical application, especially in remote-controlled release of anticancer drugs. Herein we report a novel NIR light responsive composite hydrogel system that undergoes structural changes to realize drug delivery and precise release, which are constructed by poly (N-isopropylacrylamide) network and photothermal agent 4OCSPC/F127 micelles.
关键词： PNIPAM,NIR light-responsive hydrogels,4OCSPC/F127 micelles,drug delivery,photothermal agent
更新于2025-09-23 15:21:01
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Inkless Multi-Color Writing and Copying of Laser-Programmable Photonic Crystals
摘要： Rewritable papers, as an environmentally friendly alternative for information delivery, hold great promise to reduce the abundant uses of ordinary papers that cause severe environmental problems. In recent decades, photonic crystals (PCs) have shown great potential in developing rewritable papers. However, existing PC papers still confront many challenges, including poor storage stability, short-cycle lifetime, monotonous colors, and absence of copying capability. Herein, we report the fabrication of a rewritable PC paper based on programmable configurations of a synthesized shape memory polymer (SMP). The resulting SMP-based PC paper does not need additional inks and can be facilely written by near infrared (NIR) light with assistance from a pre-printed black paper as a photothermal layer. Heating from the black paper induces various stable configurations of the PCs, thus creating multiple colors in the irradiated areas. Moreover, the PC paper possesses excellent colorful copying capability that can transform information from a paper with pre-printed black letters or complex images via scanning with NIR light. These images can be stably stored for more than 6 months at ambient conditions, which can be even erased and rewritten over 50 times without significant loss in color quality. This environment-friendly SMP-based PC paper with extraordinary properties holds great promise in the fields of next-generation office papers, smart price tags, and anti-counterfeiting labels.
关键词： NIR light,copying capability,multi-color writing,rewritable papers,photonic crystals,shape memory polymer
更新于2025-09-23 15:19:57
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Near-infrared light remotely up-regulate autophagy with spatiotemporal precision via upconversion optogenetic nanosystem
摘要： In vivo noninvasively manipulating biological functions by the mediation of biosafe near infrared (NIR) light is becoming increasingly popular. For these applications, upconversion rare-earth nanomaterial holds great promise as a novel photonic element, and has been widely adopted in optogenetics. In this article, an upconversion optogenetic nanosystem that was promised to achieve autophagy up-regulation with spatiotemporal precision was designed. The biocompatible system worked via two separated parts: blue light-receptor optogenetics-autophagy upregulation plasmids for import; and upconversion rods-encapsulated flexible capsule for converting tissue-penetrative NIR light into local visible blue light. Results validated that this system could achieve up-regulation of autophagy in vitro (in both HeLa and 293T cell lines) and remotely penetrate tissue (~3.5mm) in vivo. Since autophagy serves at a central position in intracellular signalling pathways, which is correlative with diverse pathologies, we expect that this method could establish an upconversion material-based autophagy up-regulation strategy for fundamental and clinical applications.
关键词： optogenetics,autophagy,upconversion materials,protein-protein interaction (PPI),near-infrared (NIR) light
更新于2025-09-19 17:15:36
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Extending the Photovoltaic Response of Perovskite Solar Cells into the Near‐Infrared with a Narrow‐Bandgap Organic Semiconductor
摘要： Typical lead-based perovskites solar cells show an onset of photogeneration around 800 nm, leaving plenty of spectral loss in the near-infrared (NIR). Extending light absorption beyond 800 nm into the NIR should increase photocurrent generation and further improve photovoltaic efficiency of perovskite solar cells (PSCs). Here, a simple and facile approach is reported to incorporate a NIR-chromophore that is also a Lewis-base into perovskite absorbers to broaden their photoresponse and increase their photovoltaic efficiency. Compared with pristine PSCs without such an organic chromophore, these solar cells generate photocurrent in the NIR beyond the band edge of the perovskite active layer alone. Given the Lewis-basic nature of the organic semiconductor, its addition to the photoactive layer also effectively passivates perovskite defects. These films thus exhibit significantly reduced trap densities, enhanced hole and electron mobilities, and suppressed illumination-induced ion migration. As a consequence, perovskite solar cells with organic chromophore exhibit an enhanced efficiency of 21.6%, and substantively improved operational stability under continuous one-sun illumination. The results demonstrate the potential generalizability of directly incorporating a multifunctional organic semiconductor that both extends light absorption and passivates surface traps in perovskite active layers to yield highly efficient and stable NIR-harvesting PSCs.
关键词： narrow-bandgap organic semiconductors,perovskite solar cells,NIR light harvesting,passivation
更新于2025-09-19 17:13:59
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Photocontrolled release of the anticancer drug chlorambucil with caged harmonic nanoparticles
摘要： While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy due to multidrug resistance and poor target accessibility. The limitations of conventional chemotherapy formulation has prompted the development of alternative nanomaterials-based strategies to achieve targeted and stimuli sensitive payload delivery to reach optimal local drug concentration at tumor sites. In this study, the anticancer drug chlorambucil (Clb) was conjugated to the surface of silica coated lithium niobate (LNO) harmonic nanoparticles (HNPs) using a photocaging tether based on coumarin-4-yl methyl derivative. Upon laser pulsed femtosecond irradiation at 790 nm, the second harmonic emission from the metal oxide core induced the efficient release of Clb, with concomitant contribution from the nonlinear absorption of the coumarin (CM)-based moiety.
关键词： chlorambucil,NIR-light triggered delivery,harmonic nanoparticles,second harmonic emission,photosensitive tether
更新于2025-09-12 10:27:22
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A Facile Photocontrolled Iodine‐Mediated Reversible‐Deactivation Radical Polymerization System: Solution Polymerization of Methacrylates under Irradiation with NIR LED Light
摘要： Herein, near-infrared (NIR) photocontrolled iodine-mediated reversible-deactivation radical polymerization (RDRP) of various methacrylates without external photocatalyst was developed using alkyl iodide (e.g., 2-iodo-2-methylpropionitrile, CP-I) as the initiator at room temperature. We report the first example of using a series of special solvents containing carbonyl groups (e.g., 1,3-dimethyl-2-imidazolidinone (DMI), N,N-dimethylacetamide (DMAc), tetramethylurea (TMU), 1,3-dimethyl-tetrahydropyrimidin-2(1H)-one (DMPU), and N-methyl pyrrolidone (NMP)) as both solvent and catalyst for photocontrolled RDRP under irradiation with a long wavelength (λmax = 730 nm) light-emitting diode (LED) light. Therefore, the NIR photocontrolled polymerization system has the simplest components: monomer, alkyl iodide initiator and solvent. Well-defined polymers were synthesized with excellent control over the molecular weights and molecular weight distributions (Mw/Mn < 1.21). The “living” features of this promising NIR photocontrolled iodine-mediated RDRP system were confirmed by polymerization kinetics, multiple controlled “on-off” light switching cycle regulation, and chain extension experiments. Importantly, the radical polymerizations were also proceeded successfully with various thickness of skin of pork and A4 paper to demonstrate the unique advantages of this simplest polymerization system, which benefitting from the high penetration of NIR light.
关键词： radical polymerization,photopolymerization,alkyl iodide,NIR light,photocatalyst-free
更新于2025-09-12 10:27:22
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A Facile Photocontrolled Iodine-Mediated Reversible-Deactivation Radical Polymerization System: Solution Polymerization of Methacrylates under Irradiation with NIR LED Light
摘要： Herein, near-infrared (NIR) photocontrolled iodine-mediated reversible-deactivation radical polymerization (RDRP) of various methacrylates without external photocatalyst was developed using alkyl iodide (e.g., 2-iodo-2-methylpropionitrile, CP-I) as the initiator at room temperature. We report the first example of using a series of special solvents containing carbonyl groups (e.g., 1,3-dimethyl-2-imidazolidinone (DMI), N,N-dimethylacetamide (DMAc), tetramethylurea (TMU), 1,3-dimethyl-tetrahydropyrimidin-2(1H)-one (DMPU), and N-methyl pyrrolidone (NMP)) as both solvent and catalyst for photocontrolled RDRP under irradiation with a long wavelength (λmax = 730 nm) light-emitting diode (LED) light. Therefore, the NIR photocontrolled polymerization system has the simplest components: monomer, alkyl iodide initiator and solvent. Well-defined polymers were synthesized with excellent control over the molecular weights and molecular weight distributions (Mw/Mn < 1.21). The “living” features of this promising NIR photocontrolled iodine-mediated RDRP system were confirmed by polymerization kinetics, multiple controlled “on-off” light switching cycle regulation, and chain extension experiments. Importantly, the radical polymerization were also proceeded successfully with various thickness of skin of pork and A4 paper to demonstrate the unique advantages of this simplest polymerization system, which benefitting from the high penetration of NIR light.
关键词： radical polymerization,photopolymerization,alkyl iodide,NIR light,photocatalyst-free
更新于2025-09-12 10:27:22
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Precisely photothermal controlled releasing of antibacterial agent from Bi2S3 hollow microspheres triggered by NIR light for water sterilization
摘要： Microbial contamination in water has evoked worldwide attention owing to their greatest threats to the public safety. In this work, the sea urchin-like Bi2S3 hollow microspheres have been synthesized by a hard template-assisted polyol method using ZnS composite microspheres as sacri?ced template on the large scale, which shows good biocompatibility and photothermal conversion properties. Thermal-sensitive biocompatible 1-tetradecanol (TD) combined antibacterial agents (Linalool) were loaded into the hollow cavity of the sea urchin-like Bi2S3 hollow microspheres to form TD/Linalool@Bi2S3 composites. The Bi2S3 in the TD/Linalool@Bi2S3 composites can convert the absorbed NIR energy into heat energy under the irradiation of near infrared (NIR) light, which would make the temperature to reach the melting point of the TD and Linalool can be released at same time. Thus, the antibacterial agent Linalool can be precisely controlled releasing from the formed TD/Linalool@Bi2S3 composites, which provided rapid and e?ective killing outcome in vitro for Gram-negative Escherichia coli (E. coli) and Gram-positive Stahylococcus aureus (S. aureus). Additionally, the as-prepared TD/Linalool@Bi2S3 composites exhibited superior antibacterial ability as compared to antibacterial agent treatment or photothermal therapy (PTT) alone, which can be attributed to the synergistic e?ects of the NIR light driven photothermal killing and antibacterial agent releasing. It endowed that the designed TD/Linalool@Bi2S3 composites is a promising antibacterial platform for cleaning the microbial contaminated water environment, which is of great strategic signi?cance and remains a formidable challenge for practical applications.
关键词： Water sterilization,Bi2S3 hollow microspheres,Antibacterial,NIR light responsive,Precisely controlled delivery
更新于2025-09-11 14:15:04