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Highly -sensitive near infrared luminescent nanothermometers based on binary mixture
摘要： We propose a simple strategy to obtain a luminescence intensity ratio nanothermometer operating in the near infrared range (1000 – 1700 nm) by use of binary mixtures of lanthanide doped Y2O3 selected as 1%Ho - Y2O3 + 1%Er - Y2O3 and 1%Ho - Y2O3 + 1%Nd - Y2O3. All nanoparticles were synthetized by citrate complexation method and thermally annealed at 800 °C. The temperature evolution of the emission properties was monitored in the range of 297 – 472 K and analyzed in terms of emission shape, intensity, dynamics, excitation wavelength, acquisition mode and weight ratio of the binary mixture. A maximum relative sensitivity of 1%K-1 at 297 K was recorded for the 3:1 weight ratio Ho – Y2O3 + Er – Y2O3 binary mixture upon excitation at 536.8 nm. For the more appropriate excitation wavelength for bioimaging applications at 649.7 nm, a relative sensitivity of 0.55 - 0.6 % K-1 was recorded in the relevant physiological temperature range (300 -320 K) for the 3:1 weight ratio Ho – Y2O3 + Er – Y2O3 binary mixture. To the best of our knowledge, our study also represents a first report on the near -infrared luminescence (around 1200 nm) lifetime thermometry for a Ho doped nanoparticle. Comparison with the literature demonstrates that our system represents a promising near-infrared thermometer, with a non-sophisticated and reproducible configuration that is open to multiple optimization routes.
关键词： Lifetime thermometry,Binary mixture,lanthanide doped Y2O3,Near infrared luminescence,Self-referenced nanothermometry
更新于2025-09-23 15:22:29
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A pH-insensitive near-infrared fluorescent probe for wash-free lysosome-specific tracking with long time during physiological and pathological processes
摘要： A novel dicyanomethylene-4H-pyran based lysosome-specific near-infrared (NIR) probe, DCM-ML, is reported. It exhibits very weak fluorescence (Ф=0.007) in aqueous solution due to the energy relaxation from intramolecular rotation; but a large "off-on" NIR emission (20-folds) after specifically labeling lysosomes due to the local high viscosity instead of the local pH by both one- and two-photon excitation microscopy. Therefore, the imaging ability of DCM-ML will not confront the problems suffered by the currently used and reported pH-dependent lysosome probes (e.g., once lysosomal pH increases, their fluorescence gets quenched); The pH-independent feature of DCM-ML is further demonstrated to be a great advantage for tracing lysosomes’ movements in a relatively long time, even during cellular processes when lysosomes are suffered from external stimulations that induce pH increase and apoptosis. In addition to the characteristics of pH-insensitivity and "off-on" NIR emission, DCM-ML also possesses characteristics of excellent membrane permeability, high selectivity, low cytotoxicity, good photostability and large Stokes shift (> 200 nm), which qualify it as a superior wash-free NIR probe for tracking dynamic changes of lysosomes under both physiological and toxicological conditions. Hence, we believe DCM-ML may find a great potential of application in the future.
关键词： pH-insensitivity,Long-term tracking,Wash-free,"Off-on",Lysosome-specific imaging,Near-infrared
更新于2025-09-23 15:22:29
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Facile in situ synthesis of Ag and Bi co-decorated BiOCl heterojunction with high photocatalytic performance over the full solar spectrum
摘要： Full-spectrum-responsive Ag/Bi/BiOCl hierarchical micro-flower heterojunction via a facile in-situ solvothermal route. The samples were characterized by XRD, SEM, TEM, XPS, BET and UV–Vis–NIR. The in-situ incorporation of Bi into the semiconductor BiOCl nanosheets with oxygen vacancies could be regulated efficiently by the Ag+ additive content. The samples presented a strong optical absorption in the whole region of 200–2400 nm and displayed excellent photocatalytic performance over the full solar spectrum. The presence of metallic Ag, Bi and oxygen vacancies strengthened the light absorption and promoted the charge-carrier separation of BiOCl, resulted in higher photocatalytic activity than that of pure BiOCl and P25 under UV and visible light irradiation. Furthermore, the photocatalytic responsiveness of Ag/Bi/BiOCl was successfully extended to the NIR region. On the basis of the radical species trapping experiments, h+, (cid:129)O2-, and (cid:129)OH were confirmed to be the mainly active species involved in the degradation of organic pollutants in the NIR region.
关键词： Full-spectrum,Near-infrared,Photocatalysis,Ag/Bi/BiOCl,Heterojunction
更新于2025-09-23 15:22:29
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A novel “turn-on” mitochondria-targeting near-infrared fluorescent probe for H2S detection and in living cells imaging
摘要： Hydrogen sulfide (H2S) has been considered to be involved in cytoprotective processes and redox signaling. It is very meaningful to track and analyze it in mitochondria. Herein, we report a novel “turn-on” mitochondria-targeting near-infrared fluorescent probe (Mito-NIR-SH) for detection of H2S in living cells, which was designed and synthesized by introducing 2,4-dinitrophenyl as fluorescence quenching group and H2S response moiety into Changsha near-infrared fluorophore (CS-OH). The structure of the fluorophore and the probe were characterized by 1H NMR, 13C NMR and mass spectrometry. Meanwhile, Mito-NIR-SH could quantitatively detect H2S at concentrations ranging from 0 to 30 μM with a detection limit as low as 89.3 nM, showing good chemical stability, fast “turn-on” response, selectively mitochondrial location, as well as high sensitivity and selectivity toward H2S. Based on this, it was successfully applied to imaging exogenous and endogenous H2S in living HeLa cells via confocal fluorescence microscopy.
关键词： High sensitivity and selectivity,Near-infrared fluorescent probe,Hydrogen sulfide,Mitochondria-targeting,Bioimaging
更新于2025-09-23 15:22:29
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Near-Infrared Light Triggered Sulfur Dioxide Gas Therapy of Cancer
摘要： The exploitation of gas therapy platforms holds great promise as a 'green' approach for selective cancer therapy, however, it is often associated with some challenges, such as uncontrolled or insufficient gas generation and unclear therapeutic mechanisms. In this work, a gas therapy approach based on near-infrared (NIR) light triggered sulfur dioxide (SO2) generation was developed, and the therapeutic mechanism as well as in vivo anti-tumor therapeutic efficacy was demonstrated. A SO2 prodrug-loaded rattle-structured upconversion@silica nanoparticles (RUCSNs) was constructed to enable high loading capacity without obvious leakage, and to convert NIR light into ultraviolet (UV) light so as to activate the prodrug for SO2 generation. In addition, SO2 prodrug-loaded RUCSNs showed high cell uptake, good biocompatibility, intracellular tracking ability, and high NIR light triggered cytotoxicity. Furthermore, the cytotoxic SO2 was found to induce cell apoptosis accompanied with the increase of intracellular reactive oxygen species (ROS) levels and the damage of nuclear DNA. Moreover, efficient inhibition of tumor growth was achieved, associated with significantly prolonged survival of mice. Such NIR light-triggered SO2 therapy may provide an effective strategy to stimulate further development of synergistic cancer therapy platforms.
关键词： upconversion nanoparticles (UCNPs),gas therapy,cancer therapy,near-infrared (NIR),sulfur dioxide (SO2)
更新于2025-09-23 15:22:29
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Associations of Perioperative Renal Oximetry Via Near-Infrared Spectroscopy, Urinary Biomarkers, and Postoperative Acute Kidney Injury in Infants After Congenital Heart Surgery
摘要： Objectives: Examine the relationship between perioperative renal regional tissue oximetry, urinary biomarkers, and acute kidney injury in infants after congenital cardiac surgery with cardiopulmonary bypass. Design: Prospective, observational. Setting: Cardiac operating room and cardiac ICU. Patients: Neonates and infants without history of kidney injury or anatomic renal abnormality. Interventions: None. Measurements and Main Results: Renal regional tissue oximetry was measured intraoperatively and for 48 hours postoperatively. Urinary levels of neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinases 2 together with insulin-like growth factor-binding protein 7 were measured preoperatively, 2, 12, and 24 hours postoperatively. Patients were categorized as no acute kidney injury, stage 1, or Stage 2–3 acute kidney injury using the Kidney Disease: Improving Global Outcomes criteria with 43 of 70 (61%) meeting criteria for any stage acute kidney injury. Stage 2–3 acute kidney injury patients had higher tissue inhibitor of metalloproteinases 2, insulin-like growth factor-binding protein 7 at 2 hours (0.3 vs 0.14 for stage 1 acute kidney injury and 0.05 for no acute kidney injury; p = 0.052) and 24 hours postoperatively (1.71 vs 0.27 for stage 1 acute kidney injury and 0.19 for no acute kidney injury, p = 0.027) and higher neutrophil gelatinase-associated lipocalin levels at 24 hours postoperatively (10.3 vs 3.4 for stage 1 acute kidney injury and 6.2 for no acute kidney injury, p = 0.019). Stage 2–3 acute kidney injury patients had lower mean cardiac ICU renal regional tissue oximetry (66% vs 79% for stage 1 acute kidney injury and 84% for no acute kidney injury, p = 0.038). Regression analyses showed that tissue inhibitor of metalloproteinases 2, insulin-like growth factor-binding protein 7 at 2 hours postoperatively and nadir intraoperative renal regional tissue oximetry to be independent predictors of postoperative kidney damage as measured by urinary neutrophil gelatinase-associated lipocalin. Conclusions: We observed modest differences in perioperative renal regional tissue oximetry and urinary biomarker levels compared between acute kidney injury groups classified by creatinine-dependent Kidney Disease: Improving Global Outcomes criteria, but there were significant correlations between renal regional tissue oximetry, tissue inhibitor of metalloproteinases 2, insulin-like growth factor-binding protein 7, and postoperative neutrophil gelatinase-associated lipocalin levels. Kidney injury after infant cardiac surgery may be undetectable by functional assessment (creatinine) alone, and continuous monitoring of renal regional tissue oximetry may be more sensitive to important subclinical acute kidney injury.
关键词： near-infrared spectroscopy,infant,biomarker,congenital heart surgery,cardiac intensive care unit,acute kidney injury
更新于2025-09-23 15:22:29
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Caracterización Espectral y Detección de Flecha Seca en Palma Africana en Puntarenas, Costa Rica
摘要： During the last decades, precision agriculture has observed significant technical progress that has permitted better management of farming, optimizing resources and applied inputs. Within the scope of geomatics, land optical sensors have allowed to expand and increase knowledge on the spectral behavior of the crops under study, providing increased benefits in the application of treatments and pest or disease prevention. The objective of this work was to characterize the African oil palm (Elaeis guineensis Jacq.), by means of field radiometry-spectrum, in healthy plants, as well as in plants affected by bud rot. The study was conducted between March and May 2016 in African oil palm farms in Parrita, Puntarenas, Costa Rica. A hyperspectral land sensor, with a 325-1075 nm wavelength range (visible and near-infrared spectrum), was used. In general, plants in healthy phytosanitary condition, which also had a treatment of “fertilization+irrigation”, presented the highest reflectivity curves: around 0.7%. The bud rot influence in the reflectance curve of the plants had, in most cases, a greater weight than the type of treatment to which they are subjected. It thus confirms the possibility of detecting the bud rot pathology through reflectance spectroscopy in conditions of field work, the main goal of this research.
关键词： Spectroscopy,land optical sensors,reflectance,near infrared
更新于2025-09-23 15:22:29
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Evaluating Feature Extractors and Dimension Reduction Methods for Near Infrared Face Recognition Systems
摘要： This study evaluates the performance of global and local feature extractors as well as dimension reduction methods in NIR domain. Zernike moments (ZMs), Independent Component Analysis (ICA), Radon Transform + Discrete Cosine Transform (RDCT), Radon Transform + Discrete Wavelet Transform (RDWT) are employed as global feature extractors and Local Binary Pattern (LBP), Gabor Wavelets (GW), Discrete Wavelet Transform (DWT) and Undecimated Discrete Wavelet Transform (UDWT) are used as local feature extractors. For evaluation of dimension reduction methods Principal Component Analysis (PCA), Kernel Principal Component Analysis (KPDA), Linear Discriminant Analysis + Principal Component Analysis (Fisherface), Kernel Fisher Discriminant Analysis (KFD) and Spectral Regression Discriminant Analysis (SRDA) are used. Experiments conducted on CASIA NIR database and PolyU-NIRFD database indicate that ZMs as a global feature extractor, UDWT as a local feature extractor and SRDA as a dimension reduction method have superior overall performance compared to some other methods in the presence of facial expressions, eyeglasses, head rotation, image noise and misalignments.
关键词： comparative study,undecimated discrete wavelet transform,Face recognition,near infrared,Zernike moments
更新于2025-09-23 15:22:29
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Low Renal Oxygen Saturation at Near-Infrared Spectroscopy on the First Day of Life Is Associated with Developing Acute Kidney Injury in Very Preterm Infants
摘要： Background: Acute kidney injury (AKI) is a frequent complication in preterm infants, and the identification of early markers of renal hypoperfusion is a chief challenge in neonatal intensive care units. Objectives: To describe the association between early markers of cardiovascular function and renal perfusion with AKI occurrence in a cohort of preterm infants < 32 weeks’ gestation. Methods: 128 infants were prospectively included from birth to discharge. During the first day of life, we assessed cardiovascular function, systemic and organ blood flow by Doppler ultrasound, and monitored cerebral and renal regional oxygen saturation (rSO2) using near-infrared spectroscopy (NIRS). These measures were analyzed in relation to developing AKI and serum creatinine (SCr) peak from day 2 to 7 of life. Results: 12 of 128 infants presented with AKI (9.4%). SCr peak was 155.3 ± 30.2 μmol/L in infants with AKI versus 82.0 ± 16.5 in non-AKI infants (p < 0.001). Among all measures of cardiovascular function and renal perfusion, low mean cerebral and renal rSO2 during the first day of life and a low resistive index at renal artery Doppler were significantly associated with developing AKI. After adjustment for possible confounding factors, low renal rSO2 on the first day of life remained associated with a high SCr peak from day 2 to 7 of life. Conclusion: Low renal rSO2 values during the first day of life correlate with developing AKI in preterm infants < 32 weeks’ gestation. NIRS monitoring of renal function during adaptation seems promising, and its very early use after birth to detect kidney hemodynamic dysfunction deserves further investigations.
关键词： Acute renal failure,Neonatal intensive care,Postnatal adaptation,Near-infrared spectroscopy,Renal function,Extremely low-birth-weight infants,Renal hemodynamics,Premature newborns,Patent ductus arteriosus
更新于2025-09-23 15:22:29
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Near-Infrared Annihilation of Conductive Filaments in Quasiplane MoSe <sub/>2</sub> /Bi <sub/>2</sub> Se <sub/>3</sub> Nanosheets for Mimicking Heterosynaptic Plasticity
摘要： It is desirable to imitate synaptic functionality to break through the memory wall in traditional von Neumann architecture. Modulating heterosynaptic plasticity between pre- and postneurons by another modulatory interneuron ensures the computing system to display more complicated functions. Optoelectronic devices facilitate the inspiration for high-performance artificial heterosynaptic systems. Nevertheless, the utilization of near-infrared (NIR) irradiation to act as a modulatory terminal for heterosynaptic plasticity emulation has not yet been realized. Here, an NIR resistive random access memory (RRAM) is reported, based on quasiplane MoSe2/Bi2Se3 heterostructure in which the anomalous NIR threshold switching and NIR reset operation are realized. Furthermore, it is shown that such an NIR irradiation can be employed as a modulatory terminal to emulate heterosynaptic plasticity. The reconfigurable 2D image recognition is also demonstrated by an RRAM crossbar array. NIR annihilation effect in quasiplane MoSe2/Bi2Se3 nanosheets may open a path toward optical-modulated in-memory computing and artificial retinal prostheses.
关键词： 2D materials,charge trapping,quasiplane nanosheets,near-infrared annihilation,heterostructures
更新于2025-09-23 15:22:29