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Introduction to reflectance confocal microscopy and its use in clinical practice
摘要： Re?ectance confocal microscopy (RCM) is a novel technology that provides noninvasive, in vivo imaging of the skin at nearly histologic resolution. In 2016, the US Centers for Medicare and Medicaid Services (CMS) established reimbursement codes for RCM image acquisition and for the reading and interpretation of images. The combination of RCM imaging with dermoscopy has improved the accuracy of skin cancer diagnosis while reducing the number of biopsies of benign skin lesions. With that, we are starting to see more dermatologists and dermatopathologists using RCM in clinical practice. This editorial is to serve as an introduction on RCM imaging with a focus on its usefulness in both the diagnosis and management of skin cancers. We end by brie?y describing the characteristic RCM features of normal skin to serve as a building block for later cases that will explore both the bene?ts and drawbacks of incorporating RCM imaging for benign and malignant lesions.
关键词： innovative technology,noninvasive imaging,skin cancer,melanoma,re?ectance confocal microscopy,lentigo maligna,nonmelanoma skin cancer
更新于2025-09-23 15:21:01
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The Encyclopedia of Archaeological Sciences || Multispectral and Hyperspectral Imaging
摘要： In the field of archaeology (and heritage in general), many documentation and examination methods are based on imaging techniques that characterize and depict artifacts in a nondestructive and mechanically noninvasive way. Multi- and hyperspectral imaging (together denoted spectral imaging) are two possible forms of such noninvasive imaging. Both are based on the detection of reflected or emitted optical electromagnetic radiation, the latter being defined as electromagnetic waves with wavelengths between 10 nm (0.01 μm) and 1 mm (1,000 μm). This detection can be better understood when considering that optical digital imaging usually generates a signal that is the outcome of a three-variable process: electromagnetic radiation of a radiation source falls onto the object; this radiation is partly absorbed, transmitted, and reflected by the object, with the interaction being wavelength dependent; and the imager detects and digitizes the incoming radiance in specific spectral regions. Spectral imaging extends traditional trichromatic digital camera approaches by capturing data in at least four different spectral bands, with hyperspectral imaging featuring higher spectral resolution and more contiguous spectra. Applications include archaeological prospection, color-accurate documentation, material identification, and enhancing the reading of old documents. Drawbacks involve data quantity, noise proneness, and reliance on specialized hardware and software, with future research focusing on active systems like multi-wavelength laser scanners.
关键词： multispectral imaging,archaeology,hyperspectral imaging,data cube,spectral signature,future research,drawbacks,electromagnetic radiation,noninvasive imaging,applications,spectral imaging,heritage
更新于2025-09-19 17:15:36
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Apport de la microscopie confocale par réflectance et de l’OCT dans le diagnostic d’un carcinome basocellulaire nodulaire kystique
摘要： The role of reflectance confocal microscopy and OCT in the diagnosis of nodular kystic BCC
关键词： Basal cell carcinoma,Noninvasive imaging,Optical coherence tomography,In vivo confocal microscopy,Dermoscopy,In vivo reflectance confocal microscopy,Cystic basal cell carcinoma
更新于2025-09-19 17:15:36
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Noninvasive In Vivo Imaging in the Second Near-Infrared Window by Inorganic Nanoparticle-Based Fluorescent Probes
摘要： The fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) has emerged as a new method for in vivo imaging and attracted considerable attention in the past decade. Owing to the suppressed photon scattering and diminished autofluorescence, in vivo fluorescence imaging in NIR-II window can afford deep tissue penetration depth with high clarity. Inorganic nanoparticle-based fluorescent probes in NIR-II window have greatly prospered the field into a development stage because of their superior traits, including adjustable emission covering the whole NIR-II window, and abundant surface functional groups that facilitate chemical modification and bioconjugation, etc. In this feature article, we introduce the unique imaging performance of the NIR-II optical window, and highlight the latest development of noninvasive biological fluorescent imaging in NIR-II window using inorganic nanoparticle-based probes. A perspective on the challenge and future direction of inorganic nanoparticle-based NIR-II probes is also discussed.
关键词： noninvasive imaging,NIR-II,inorganic nanoparticles,fluorescence imaging,in vivo imaging
更新于2025-09-11 14:15:04