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Characterization of Breast Lesions: Comparison of Digital Breast Tomosynthesis and Ultrasonography
摘要： Objective: To compare the diagnostic performance of digital breast tomosynthesis (DBT) and conventional breast ultrasound (US) to characterize breast lesions as benign or malignant. Materials and Methods: A total of 332 women, presenting for screening examinations or for breast biopsy between March and June 2012 were recruited to undergo digital mammography (DM), DBT, and breast US examination. Among them, 113 patients with 119 breast lesions depicted on DM were finally included. Three blinded radiologists performed an enriched reader study and reviewed the DBT and US images. Each reader analyzed the lesions in random order, assigned Breast Imaging Reporting and Data System (BI-RADS) descriptors, rated the images for the likelihood of malignancy (%) and made a BI-RADS final assessment. Diagnostic accuracy, as assessed by the area under the receiver operating characteristic curve, sensitivity, and specificity of DBT and US were compared. Results: Among the 119 breast lesions depicted on DM, 75 were malignant and the remaining 44 were benign. The average diagnostic performance for characterizing breast lesions as benign or malignant in terms of area under the curve was 0.899 for DBT and 0.914 for US (p = 0.394). Mean sensitivity (97.3% vs. 98.7%, p = 0.508) and specificity (44.7% vs. 39.4%, p = 0.360) were also not significantly different. Conclusion: Digital breast tomosynthesis may provide similar reader lesion characterization performance to that of US for breast lesions depicted on DM.
关键词： Breast US,Digital breast tomosynthesis,Diagnostic performance
更新于2025-09-23 15:23:52
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Synthesizing mammogram from digital breast tomosynthesis
摘要： The purpose of this study is to develop a new method for generating synthesized mammogram (SM) from digital breast tomosynthesis (DBT) and to assess its potential as an adjunct to DBT. We first applied multiscale bilateral filtering to the reconstructed DBT slices to enhance the high-frequency features and reduce noise. A maximum intensity projection (MIP) image was then obtained from the high-frequency components of the DBT slices. A multiscale image fusion method was designed to combine the MIP image and the central DBT projection view into an SM and further enhance the high-frequency features. We conducted a pilot reader study to visually assess the image quality of SM in comparison to full field digital mammograms (FFDM). For each DBT craniocaudal or mediolateral view, a clinical FFDM of the corresponding view was retrospectively collected. Three MQSA radiologists, blinded to the pathological and other clinical information, independently interpreted the SM and the corresponding FFDM side by side marked with the lesion locations. The differences in the BI-RADS assessments of both MCs and masses between SM and FFDM did not achieve statistical significance for all 3 readers. The conspicuity of MCs on SM was superior to that on FFDM and the BI-RADS assessments of MCs were comparable while the conspicuity of masses on SM was degraded and interpretation on SM was less accurate than that on FFDM. The SM may be useful for efficient prescreening of MCs in DBT but the DBT should be used for detection and characterization of masses.
关键词： synthesized mammography (SM),digital breast tomosynthesis (DBT),breast cancer
更新于2025-09-23 15:23:52
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Experimental evaluation of seven quality control phantoms for digital breast tomosynthesis
摘要： Keywords: Breast, Diagnostic imaging, Digital breast tomosynthesis, Quality control, Screening. Purposes: The introduction of digital breast tomosynthesis (DBT) into the French breast cancer screening program is forecast by the authorities. The aim of the present study was to evaluate image quality phantoms to be used as internal quality controls. Methods: Seven breast phantoms dedicated to quality control in mammography were evaluated on reconstructed DBT images: ACR Model 015, BR3D, DBT QC model 021, Mam/Digi-EPQC, MTM100, TOMOMAM? and TOMOPHAN?. Two representative image parameters of DBT images were studied: image score and z-resolution, when inserts were included in the phantom, on five DBT systems of three different brands. Three observers were involved. Results: The MTM100, Mam/Digi-EPQC, BR3D, DBT QC model 021 phantoms' images presented artefacts affecting the image score. The ACR Model 015, TOMOMAM? and TOMOPHAN? phantoms appeared to be pertinent for DBT image score analysis. Due to saturation artefacts, Z-resolution results were not coherent with the theory for all phantoms except by using aluminium beads in the TOMOMAM? phantom. Conclusions: Phantom manufacturers should be encouraged to collaborate with DBT system manufacturers in order to design universal phantoms suitable for all systems for more complete quality control. From our study we can propose several specifications for an ideal and universal phantom designed for internal quality control in DBT. Phantoms should allow sensitive image score measurements. The background structure should be realistic to avoid artefacts. Phantoms should have a standard breast-like shape and size.
关键词： Breast,Digital breast tomosynthesis,Screening,Diagnostic imaging,Quality control
更新于2025-09-23 15:22:29
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Effective detective quantum efficiency of two detectors in a prototype digital breast tomosynthesis
摘要： Digital breast tomosynthesis (DBT) system is a novel imaging modality that strongly depends on the detector performance. The effective detective quantum efficiency (eDQE) is a newly accepted system of performance analysis metric that solves the disadvantages of conventional DQE evaluations, which do not consider clinical operating conditions. To evaluate the eDQE, we used the direct-conversion based Anrad detector and the indirect-conversion based Dexela detector. Our aim is to study the performance of such detectors when they are mounted on a prototype DBT system. The prototype DBT system consists of a CsI(Tl) scintillator/CMOS-based flat panel digital detector and an a-Se based direct conversion detector developed by the Korea Electrotechnology Research Institute (KERI). The performance of the two detectors was compared on the basis of scatter fraction, transmission factor, effective modulation transfer function (eMTF), and effective normalized noise power spectrum (eNNPS). As a result, the Dexela detector is characterized by a decreasing eNNPS trend as the spatial frequency increases, whereas the Anrad eNNPS looks almost independent of the spatial frequency. The eMTF was found to be higher in the Anrad detector compared to that in the Dexela one for all frequencies. The eDQE values at 1 cycle/mm (low frequency) were 0.11 and 0.17 for the Anrad and Dexela detectors, respectively, and the values of the spatial frequency feDQE (0.1), corresponding to eDQE = 0.1, were 1.25 and 2.81 cycles/mm for the Anrad and Dexela detectors, respectively. The Dexela detector also presented a higher contrast-to-noise ratios (CNRs) for all different sizes of μCa groups, thus demonstrating overall better eDQE results in imaging performance compared to the Anrad detector.
关键词： Direct/indirect conversion detectors,Effective detective quantum efficiency,Digital breast tomosynthesis
更新于2025-09-23 15:22:29
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New Perspectives in Breast Imaging || Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography
摘要： According to global statistics, there is a high incidence of cancer in western countries; and, due to the limited resources available in most healthcare systems, it seems like one of the most feasible options to fight against cancer might be strict prevention policies—such as eliminating carcinogens in people’s daily lives. Nevertheless, early cancer detection and effective treatment are still necessary, and understanding their efficacy and limitations are important issues that need to be addressed in order to ultimately enhance patients’ survival rate. In the case of breast cancer, some of the problems faced by conventional mammography have been addressed in the literature; they include high rate of false-positive and false-negative results, as well as the possibility of overdiagnosis. New technologies, such as digital breast tomosynthesis (DBT), have been able to improve the sensitivity and specificity by using 3D imaging. However, the low contrast (1%) existing between tumors and healthy fibroglandular tissue at X-ray frequencies has been identified as one of the main causes of misdiagnosis in both conventional 2D mammography and DBT. Near-field radar imaging (NRI) provides a unique opportunity to overcome this problem, since the contrast existing between the aforementioned tissues is intrinsically higher (10%) at microwave frequencies. Moreover, the low resolution and highly complex scattering patterns of microwave systems can be enhanced by using prior information from other modalities, such as the DBT. Therefore, a multimodal DBT/NRI imaging system is proposed to exploit their individual strengths while minimizing their weaknesses. In this work, the foundation of this idea is reviewed, and a preliminary design and experimental validation of the NRI system, used as a DBT complement, is introduced.
关键词： breast cancer statistics,digital breast tomosynthesis,microwave imaging,antipodal Vivaldi antennas,near-field radar imaging,breast cancer detection
更新于2025-09-23 15:21:01
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Usefulness of digital breast tomosynthesis for non-calcified benign breast masses
摘要： Digital breast tomosynthesis (DBT) is a new modality that assists in detection of breast cancer. However, benign masses are also detected more easily by DBT and may require further workup. This article reviews typical imaging features of non-calci?ed benign masses on DBT. We also discuss the management of these benign masses. Knowledge of the imaging features of benign masses on DBT is required to minimize unnecessary callbacks.
关键词： Non-calci?ed benign breast masses,Breast cancer,Management,Digital breast tomosynthesis,Imaging features
更新于2025-09-23 15:19:57
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Quantitative analysis of radiation dosage and image quality between digital breast tomosynthesis (DBT) with two-dimensional synthetic mammography and full-field digital mammography (FFDM)
摘要： Purpose: Currently in diagnostic setting for breast cancer, FFDM and DBT are performed conjunctively. However, performing two imaging modalities may increase radiation exposure by double. Two-dimensional reconstructed images created from DBT with 2DSM, has a potential to replace conventional FFDM in concerning both radiation dosage and image quality. With increasing concerns for individual radiation exposure, studies analyzing radiation dosage in breast imaging modalities are needed. This study compared radiation dosage and image quality between DBT + 2DSM versus FFDM. Methods and materials: 374 patients (mean age 52 years) who underwent both DBT and FFDM were retrospectively reviewed. Radiation dosage data were obtained by radiation dosage scoring and monitoring program Radimetrics (Bayer HealthCare, Whippany, NJ). Entrance dose and mean glandular doses in each breast were obtained for both modalities. To compare image quality of DBT + 2DSM and FFDM, a 5-point scoring system for lesion clarity was assessed. The parameters of radiation dosage (entrance dose, mean glandular dose) and image quality (lesion clarity scoring) were compared. Results: For entrance dose, DBT had lower mean dosage (14.8 mGy) compared with FFDM (21.8 mGy, p-value < 0.0001). Mean glandular doses for both breasts were lower in DBT (Left 1.74, Right 2.1) compared with FFDM (Left 2.85, Right 2.74, p-value < 0.0001). Lesion clarity score was higher in DBT with 2DSM (mean score 4.03) compared with FFDM (3.82, p-value < 0.0001). Conclusion: DBT showed lower radiation entrance dose and mean glandular doses to both breasts compared with FFDM. DBT + 2DSM had better image quality than FFDM, suggesting that DBT with 2DSM has potential as an alternative to FFDM.
关键词： Radimetrics,Full-field digital mammography,Image quality,2-Dimensional synthetic mammography,Digital breast tomosynthesis,Radiation dose
更新于2025-09-19 17:15:36
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[ACM Press the 2nd International Conference - Sydney, NSW, Australia (2018.10.06-2018.10.08)] Proceedings of the 2nd International Conference on Graphics and Signal Processing - ICGSP'18 - CNN-Based CAD for Breast Cancer Classification in Digital Breast Tomosynthesis
摘要： Digital breast tomosynthesis (DBT) is a promising new technique for breast cancer diagnosis. DBT has the potential to overcome the tissue superimposition problems that occur on traditional mammograms for tumor detection. However, DBT generates numerous three-dimensional images, thereby creating a heavy workload for radiologists. Therefore, constructing an automatic computer-aided diagnosis (CAD) system for DBT image analysis is necessary. This study compared feature-based CAD and convolutional neural network (CNN)-based CAD for breast cancer classification from DBT images. The research methods included image preprocessing, candidate tumor identification, feature generation, classification, image cropping, augmentation, CNN model design, and deep learning. The accuracy rates (standard deviation) of the CNN- and feature-based CAD for breast cancer classification were 74.85% (0.122) and 87.12% (0.035), respectively. The T value was ?6.229, and the P value was 0.00 < 0.05, which indicated that the CNN-based CAD significantly outperformed feature-based CAD. The results can be applied to clinical medicine and assist radiologists in breast cancer identification.
关键词： computer-aided diagnosis,breast cancer classification,deep learning,Digital breast tomosynthesis
更新于2025-09-11 14:15:04
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Simultaneous measurement of patient dose and distribution of indoor scattered radiation during digital breast tomosynthesis
摘要： Introduction: Breast cancer incidence increases from the age of 30 years. As this age range coincides with that in which women usually pursue pregnancy, undergoing medical examinations for conditions such as breast cancer is a concern, especially when pregnancy is uncertain during the first eight weeks. Moreover, in this age range, breast often exhibits a high density, thus compromising diagnosis. For such density, digital breast tomosynthesis (DBT) provides a more accurate diagnosis than 2D mammography given its higher sensitivity and specificity. However, radiation exposure increases during DBT, and it should be determined. Methods: We determined the entrance surface dose, scattered radiation dose, and average glandular dose (AGD), which can be mutually compared following an international protocol. Using our proposed method, the distribution of scattered radiation can be easily and quickly obtained with a minor load to the equipment. Then, we can determine the indoor scattered radiation and surface dose on patients during DBT. Results: We obtained a maximum AGD of 2.32 mGy. The scattered radiation was distributed over both sides with maximum of approximately 40 mGy, whereas the maximum dose around the eye was approximately 10 mGy. Conclusion: By measuring doses using the proposed method, a correct dose information can be provided for patients to mitigate their concerns about radiation exposure. Although the obtained doses were low, their proper management is still required. Overall, the results from this study can help to enhance dose management for patients and safety management regarding indoor radiation.
关键词： Radiation safety,Entrance surface dose,Jungle gym method,Scatter dose,Digital breast tomosynthesis,Average glandular dose (AGD)
更新于2025-09-10 09:29:36
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Assessment of scatter radiation dose and absorbed doses in eye lens and thyroid gland during digital breast tomosynthesis
摘要： Digital breast tomosynthesis (DBT) is an alternative tool for breast cancer screening; however, the magnitude of peripheral organs dose is not well known. This study aimed to measure scattered dose and estimate organ dose during mammography under conventional (CM) and Tomo (TM) modes in a specific DBT system. Optically stimulated luminescence dosimeters (OSLDs), whose responses were corrected using a parallel‐plate ionization chamber, were pasted on the surface of custom‐made polymethyl methacrylate (PMMA) and RANDO phantoms to measure entrance surface air kerma (ESAK). ESAK measurements were also acquired with a 4.5‐cm thick breast phantom for a standard mammogram. Organ dose conversion factors (CFD) were determined as ratio of air kerma at a specific depth to that at the surface for the PMMA phantom and multiplied by the ratio of mass energy absorption coefficients of tissue to air. Normalized eye lens and thyroid gland doses were calculated using the RANDO phantom by multiplying CFD and ESAK values. Maximum variability in OSLD response to scatter radiation from the DBT system was 33% in the W/ Rh spectrum and variations in scattered dose distribution were observed between CM and TM. The CFD values for eye lens and thyroid gland ranged between 0.58 to 0.66 and 0.29 to 0.33, respectively. Mean organ doses for two‐view unilateral imaging were 0.24 (CM) and 0.18 (TM) μGy/mAs for the eye lens and 0.24 (CM) and 0.25 (TM) μGy/mAs for the thyroid gland. Higher organ doses were observed during TM compared to CM as the automatic exposure control (AEC) system resulted in greater total mAs values in TM.
关键词： mammography,optically stimulated luminescence dosimeter,eye lens dose,digital breast tomosynthesis,scatter radiation
更新于2025-09-10 09:29:36