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Hyperthermia Induced by Near-Infrared Laser-Irradiated CsWO3 Nanoparticles Disintegrates Preformed Lysozyme Amyloid Fibrils
摘要： This research study attempts to prove the concept of the applicability of hyperthermia to treating the lysozyme amyloid fibrils (LAF)’s self-assembled fibrillary aggregates by a feedback-modulated temperature controller ranging from 26 °C to 80 °C, and separately, by near-infrared (NIR) laser-irradiated cesium tungstate (CsWO3) nanoparticle (NPs). The dependence of the final morphology of the amyloidal assembly on external heating and the photothermal effect of the NPs on treating the fibrillary assembly were investigated and analyzed. Experimentally, atomic force microscopy (AFM), optical stereoscopy, and scanning electron microscopy (SEM) were used primarily to ensure mutual interaction between LAF and NPs, optically elucidate the surface contour and final fibrillary assembly upon the influence of thermal treatment, and further reveal fine-details of the optical samples. Finally, conclusive remarks are drawn that the fibrillary structures doped with the NPs exhibit an increasing degree of unique orthogonality. As the temperature rises, utter deformation of the dendritic structures of fibrillary assemblies at 70 °C was found, and NIR laser-irradiated CsWO3 NPs have been demonstrated to be useful in topically destructing pre-assembled LAFs, which may be conducive to the future development of neurodegenerative therapeutic techniques.
关键词： neurodegenerative diseases,self-assembled nanocomposite,lysozyme amyloid fibrils,hyperthermia,cesium tungsten oxide nanoparticles
更新于2025-09-16 10:30:52
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[Methods in Molecular Biology] || Multifunctional Magnetic Nanoparticles-Labeled Mesenchymal Stem Cells for Hyperthermia and Bioimaging Applications
摘要： Magnetic nanoparticles have demonstrated considerable capacity for theranosis purposes due to their unique characteristics, including magnetic properties, comparable size to biomolecules, favorable conjugations of drugs and biomolecules, ability to labeling, and capability of sensing, separation, detection, and targeted drug delivery. They could be exploited in magnetic resonance imaging as the contrast agents and also warmed as exposed to an external magnetic AC ?eld that could be applied in hyperthermia. Here, progresses and advances in the strategy and assembly of ?uorescent magnetic nanoparticles are presented for stem cell tracing and drugs/biomolecules targeting into cells.
关键词： Conjugation,Fluorescent probe,Stem cell tracing,Magnetic resonance imaging,Magnetic nanoparticles,Hyperthermia
更新于2025-09-12 10:27:22
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Janus shaped plasmonic-magnetic silver-magnetite nanostructures for multimodal applications
摘要： The multifunctional biocompatible Janus shaped plasmonic-magnetic silver-magnetite nanoparticles have been developed via a single phase microemulsion technique and investigated for different physical properties. The noble metal integration with magnetite nanoparticles introduces superior optical properties into the nanostructures. The dynamic light scattering technique has been used to measure the hydrodynamic size, monodispersity and zeta potential to check their suitability as multimodal agents. The synthesized silver-magnetite nanoparticles are monodispersed and possess colloidal stability. The UV–visible spectra for Janus silver-magnetite nanoparticles shows a surface plasmon resonance peak at 372 and 474 nm which lies in the visible region of electromagnetic spectrum. The photoluminescence spectrum confirms the obtained nanoparticles to be optically active. The measurements of response for bare magnetite as well as silver-magnetite nanoparticles in an alternating magnetic field reveal their suitability in hyperthermia applications. These synthesized integrated magnetite-silver nanostructures show its potential as an excellent candidate for multimodal applications.
关键词： plasmonic-magnetic,Janus nanoparticles,hyperthermia,silver-magnetite,multimodal applications
更新于2025-09-11 14:15:04
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Enhancement of Luminescence Intensity in Dy3+ Ions Doped YVO4 Nanomaterials by Ba2+ Ion Codoping and YVO4:2Dy/Fe3O4 Nanohybrid for Hyperthermia Application
摘要： The enhancement of the luminescence intensity of the Dy3+ by Ba2+ ions (at different concentrations) codoping into YVO4:2Dy nanoparticles at different annealing temperature of as-prepared, at 500 and 900°C were studied. The XRD study shows the strains are induced when dopant and codopant are incorporated into host matrix. XRD patterns of nanohybrids show the existence of two phases corresponding to YVO4:2Dy and Fe3O4 nanoparticles. TEM image of YVO4:2Dy nanoparticles were spherical shape whereas for YVO4:2Dy/Fe3O4 nanohybrids, the spherical particles are forming chain like structure due to the PEG molecule which binds both YVO4:2Dy and Fe3O4 during nanohybrids formation. Increase in absorption coefficient and decrease in lattice strain values are the major reasons for the enhancement of emission intensity in photoluminescent (PL). Lifetime studies also shows correlation between the calculated energy transfer and diffusion for indirect excitation which is also studied here. High quantum efficiency up to 45% can be achieved. YVO4:2Dy/Fe3O4 nanohybrids is found to achieve hyperthermia temperature 42°C in short time. This nanohybrids shows luminescence in the region of biological window indicating nanohybrids can be used as bioimaging probe. It also shows high viability up to 94% in HeLa cancer cells.
关键词： Vanadate nanoparticles,HeLa cell,Nanohybrids,Enhancement of luminescence,Hyperthermia
更新于2025-09-09 09:28:46
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Targeted near infrared hyperthermia combined with immune stimulation for optimized therapeutic efficacy in thyroid cancer treatment
摘要： Treatment of thyroid cancer has incurred much focus because of its high prevalency. As a new strategy treating thyroid cancer, hyperthermia takes several advantages compared with surgery or chemotherapy, including minimal invasion, low systematic toxicity and the ability to enhance the immunogenicity of cancer cells with the expression Hsp70 which serves as Toll-like receptors-4 (TLR-4 agonist). However, Hsp70 as a molecular chaperone can protect cells from heat induced apoptosis and therefore compromise the tumor killing effect of hyperthermia. In this study, to solve this problem, a combined hyperthermia therapy was employed to treat thyroid cancer. We prepared a probe with the tumor targeting agent AG to monitor thyroid tumor issue and generate heat to kill tumor cells in vivo. At the same time Quercetin (inhibitor of HSP70) and lipopolysaccharide (LPS) (agonist of TLR-4) were used for the combined hyperthermia therapy. The results showed that compared with free IR820, AG modification facilitated much enhanced cellular uptake and greatly pronounced tumor targeting ability. The combined therapy exhibited the most remarkable tumor inhibition compared with the single treatments both in vitro and in vivo. These findings verified that the new therapeutic combination could significantly improve the effect of hyperthermia and shed light on a novel clinical strategy in thyroid cancer treatment.
关键词： IR820,amino-glucose,near infrared hyperthermia,tumor targeting,heat shock protein 70
更新于2025-09-09 09:28:46
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[Institution of Engineering and Technology 12th European Conference on Antennas and Propagation (EuCAP 2018) - London, UK (9-13 April 2018)] 12th European Conference on Antennas and Propagation (EuCAP 2018) - Convex Lenses Horn Antenna Microwave Hyperthermia Scheme
摘要： This paper presents a new preclinical microwave hyperthermia system based on the combination among horn antenna and convex lenses. The horn antenna is designed to resonate at 3 GHz which is reported for hyperthermia therapy. Two convex lenses are designed and incorporated with the designed horn antenna and the reported breast phantom. The proposed system aims to heat up the tumor region above 42oC while keeping the surrounding area temperature unchanged as possible to protect them from damage. Specific Absorption Rate (SAR) and breast phantom thermal distribution are studied with and without using lenses at different inclination angles. The proposed system has the advantage of heating up different zones separately while keeping other regions temperature unchanged. Simulation results show the breast temperature can be elevated by 10o C above the normal body temperature.
关键词： Convex lens,Horn antenna,Microwave hyperthermia,Tumor,Specific absorption rate
更新于2025-09-04 15:30:14
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Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
摘要： Silica–gold nanoshell (SGNS), which is a silica core surrounded by a gold layer, was synthesized by seed-mediated coalescence of gold clusters in an electroless plating solution. SGNS variations with different surface coverage of gold clusters were prepared by adjusting the amounts of gold salts in the presence of formaldehyde-reducing agents. Fully covered SGNS (f-SGNS) with connected gold clusters exhibited stronger intensity and more redshift of plasmon bands located around 820 nm than those of partially covered SGNS (p-SGNS) with disconnected gold clusters. Upon irradiation with near-infrared light (30 W/cm2, 700–800 nm), f-SGNS caused a larger hyperthermia effect, generating a large temperature change (?T =42°C), as compared to the relatively small temperature change (?T =24°C) caused by p-SGNS. The therapeutic antibody, Erbitux? (ERB), was further conjugated to SGNS for specific tumor cell targeting. The f-ERB-SGNS showed excellent therapeutic efficacy based on the combined effect of both the therapeutic antibody and the full hyperthermia dose under near-infrared irradiation. Thus, SGNS with well-controlled surface morphology of gold shells may be applicable for near-infrared-induced hyperthermia therapy with tunable optical properties.
关键词： gold nanoshell,plasmon resonance,human epithelial cancer,Erbitux,hyperthermia
更新于2025-09-04 15:30:14