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Systematic Review and Meta-Analysis of Method Comparison Studies of Masimo Pulse Co-Oximeters (Radical-7 <sup>?</sup> or Pronto-7 <sup>?</sup> ) and HemoCue? Absorption Spectrometers (B-Hemoglobin or 201+) with Laboratory Haemoglobin Estimation
摘要： We assessed agreement in haemoglobin measurement between Masimo pulse co-oximeters (Rad-7? and Pronto-7?) and HemoCue? photometers (201+ or B-Hemoglobin) with laboratory-based determination and identified 39 relevant studies (2915 patients in Masimo group and 3084 patients in HemoCue group). In the Masimo group, the overall mean difference was -0.03 g/dl (95% prediction interval -0.30 to 0.23) and 95% limits of agreement -3.0 to 2.9 g/dl compared to 0.08 g/dl (95% prediction interval -0.04 to 0.20) and 95% limits of agreement -1.3 to 1.4 g/dl in the HemoCue group. Only B-Hemoglobin exhibited bias (0.53, 95% prediction interval 0.27 to 0.78). The overall standard deviation of difference was larger (1.42 g/dl versus 0.64 g/dl) for Masimo pulse co-oximeters compared to HemoCue photometers. Masimo devices and HemoCue 201+ both provide an unbiased, pooled estimate of laboratory haemoglobin. However, Masimo devices have lower precision and wider 95% limits of agreement than HemoCue devices. Clinicians should carefully consider these limits of agreement before basing transfusion or other clinical decisions on these point-of-care measurements alone.
关键词： oximetry,haemoglobin
更新于2025-09-19 17:15:36
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[IEEE 2019 IEEE 46th Photovoltaic Specialists Conference (PVSC) - Chicago, IL, USA (2019.6.16-2019.6.21)] 2019 IEEE 46th Photovoltaic Specialists Conference (PVSC) - Elevating Low-Quality Silicon Wafers For High-Efficiency Silicon Heterojunction Solar Cell Applications
摘要： This paper relates to a genuine wrist pulse oximeter, which is a noninvasive medical device that can measure the pulse rate and oxygen saturation level in a person’s blood. The device is novel due to its innovative design. It is a new type of re?ective oximeter, which has a concave structure for housing the optical source and sensor. The neo-re?ective sensor module of the device is designed to send the sensor data to a nearby intelligent mobile phone using wireless data transmission. The pulse oximeter has been developed and calibrated, and the calibration curve was analyzed. The innovative design of this pulse oximeter would enable the user to wear the low-cost device on one wrist continuously throughout the day, without the inconvenience of a conventional ?nger pulse oximeter.
关键词： wrist oximeter,Biomedical sensor,blood oxygen saturation,re?ective oximetry,pulse oximetry
更新于2025-09-19 17:13:59
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Organic Multi-Channel Optoelectronic Sensors for Wearable Health Monitoring
摘要： Recent progress in printed optoelectronics and their integration in wearable sensors have created new avenues for research in reflectance photoplethysmography (PPG) and oximetry. The reflection-mode sensor, which consists of light emitters and detectors, is a vital component of reflectance oximeters. Here, we report a systematic study of the reflectance oximeter sensor design in terms of component geometry, light emitter and detector spacing, and the use of an optical barrier between the emitter and the detector to maximize sensor performance. Printed red and near-infrared (NIR) organic light-emitting diodes (OLEDs) and organic photodiodes (OPDs) are used to design three sensor geometries: (1) Rectangular geometry, where square OLEDs are placed at each side of the OPD; (2) Bracket geometry, where the OLEDs are shaped as brackets and placed around the square OPD; (3) Circular geometry, where the OLEDs are shaped as block arcs and placed around the circular OPD. Utilizing the bracket geometry, we observe 39.7% and 18.2% improvement in PPG signal magnitude in the red and NIR channels compared to the rectangular geometry, respectively. Using the circular geometry, we observe 48.6% and 9.2% improvements in the red and NIR channels compared to the rectangular geometry. Furthermore, a wearable two-channel PPG sensor is utilized to add redundancy to the measurement. Finally, inverse-variance weighting and template matching algorithms are implemented to improve the detection of heart rate from the multi-channel PPG signals.
关键词： flexible electronics,printed electronics,pulse oximetry,organic optoelectronics,Reflection photoplethysmography sensor,wearable sensors
更新于2025-09-11 14:15:04
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MULTISPECTRAL IMAGING SYSTEM FOR QUANTITATIVE ASSESSMENT OF TRANSCUTANEOUS BLOOD OXYGEN SATURATION
摘要： This paper presents the use of Extended Modified Lambert Beer (EMLB) model for quantification of transcutaneous blood oxygen saturation (StO2) via a noninvasive approach. Continuous wave (CW) reflectance spectroscopy system is employed for measurement of intensity reflected from left index finger of an Asian nonsmoking volunteer at resting condition. Multispectral images captured in the wavelength range of 520 ? 600 nm at an interval of 10 nm are mathematically analyzed and fitted using the developed fitting algorithm to give the best estimation of StO2. The result from this preliminary study revealed a mean StO2 value of 75 ± 5% for the participating individual, which value agreed considerably well with that presented in previous works. This work concluded that the developed spectroscopy system and quantification technique can potentially be used as an alternative means to clinical assessment of wound healing progress.
关键词： Transcutaneous blood oxygen saturation,reflectance spectroscopy,Extended Modified Lambert Beer model,skin oximetry
更新于2025-09-11 14:15:04
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Pulse Oximetry Screening for Detection of Critical Congenital Heart Defects: Why to Bother?
摘要： Congenital heart defects (CHD) are the commonest form of congenital malformations affecting 6-8 infants per 1,000 live births. Although congenital heart disease remains an important cause of death in infancy, not all forms of major congenital heart disease will be evident at birth or in the early neonatal period. The current screening tools for detection of CHD are: fetal anomaly screening ultrasound and routine examination of newborn prior to discharge from the hospital. Both of these screening tools have a low detection rate and the studies report that up a third of infants with moderate to severe CHD may be discharged home undiagnosed. Critical congenital heart defects (CCHD) are the most serious form of CHD and defined as conditions requiring surgery or intervention within the first 28 days after birth or result in death. The incidence of CCHD is 2-3 per 1,000 live births. Infants with a CCHD are at risk of sudden deterioration following closure of the ductus arteriosus and can result in cardiovascular collapse, acidosis and death. Early diagnosis of such babies would improve survival, as well as reducing the morbidity associated with circulatory collapse prior to recognition of a problem and administration of appropriate treatment. The infants with CCHD remain well while in-utero because of the fetal circulation. However, majority of infants with CCHD are likely to have some degree of hypoxaemia soon after birth. The infants with moderate or severe hypoxia can be detected clinically, but hypoxia in infants with CCHD is often mild soon after birth making it difficult to detect clinically. Interestingly this can be detected by a very simple test – pulse oximetry. Pulse oximetry is a well-established, simple, visible, fast, accurate and non-invasive method of detecting hypoxaemia. This can objectively quantify the degree of hypoxaemia in asymptomatic infants. Pulse oximetry screening has been well-studied in over 230,000 infants enrolled in many well designed research studies and randomised controlled trials. In 2012, a systematic review and meta-analysis published reported that pulse oximetry screening has a high specificity, moderate sensitivity and a low false-positive rate. This meta-analysis identified 13 studies, of over quarter of a million babies, investigating the use of pulse oximetry screening in detection of CCHDs. The overall sensitivity for pulse oximetry screening was 76.5%, the specificity 99.9% and false positive rate 0.14%. This review concluded that pulse oximetry meets criteria for universal screening for detection of CCHDs6. The addition of pulse oximetry screening to exiting screening tools may increase detection rates for CCHD to over 90%. Other studies have established its cost-effectiveness, acceptability to parents and staff and feasibility of implementing screening outside the research context. In addition, the detection of non-critical CHDs and significant non-cardiac conditions such as respiratory problems or early-onset sepsis is reported as an additional benefit of pulse oximetry screening if performed early. These clinically important conditions contributed to up to two third of the reported false positive groups which reduces the clinically non-significant false positivity to half. In 2011, the United States Health and Human Services recommended adding pulse oximetry screening to the uniform newborn panel and since then pulse oximetry screening is being established as a national US government policy. In recent years, pulse oximetry screening has been recommended by several European countries including Switzerland, Ireland and Poland. The UK national Screening Committee (UK NSC) has recently completed a pilot study on feasibility and implications of pulse oximetry screening. However, it is noteworthy to understand that not all CCHDs are likely to be detected on pulse oximetry screening. In summary, pulse oximetry screening is feasible, cost-effective, and acceptable to staff and parents. It qualifies the criteria for universal screening programme for detection of CCHD, and recently has been recommended by many countries to include in their national screening programme. Adding pulse oximetry screening as an adjunct to the existing screening tools can help in detecting up to 90% CCHDs. However, parents and health care professionals need to aware that not infants with CCHD can be detected with pulse oximetry screening and this test has its own limitations.
关键词： Screening,Critical congenital heart defects,Hypoxaemia,Pulse oximetry,CCHD
更新于2025-09-10 09:29:36
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Arterial Oxygen Saturation, Pulse Oximetry, and Cerebral and Tissue Oximetry in Hypobaric Hypoxia
摘要： Clinical accuracy of pulse oximeters (giving Spo2) is routinely tested down to an Sao2 of 70%, but lower oxygen saturations are often experienced during hypobaric hypoxia. Cerebral (Sco2) and peripheral tissue (Sto2) oxygen saturations can be measured using near infra-red spectroscopy. In a project simulating oxygen system failure during high altitude-high opening parachuting (HAHO), Sao2, Spo2, Sco2, and forearm Sto2 were measured. The aim of the present analysis was to explore the agreement between Sao2 and the three noninvasive measurements of hypoxemia (Spo2, Sco2, and Sto2).
关键词： blood gas analysis,hypoxia,atmospheric pressure,oximetry
更新于2025-09-10 09:29:36
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Identification of return of spontaneous circulation during cardiopulmonary resuscitation via pulse oximetry in a porcine animal cardiac arrest model
摘要： In this prospective study we investigated whether the pulse oximetry plethysmographic waveform (POP) could be used to identify return of spontaneous circulation (ROSC) during cardio-pulmonary resuscitation (CPR). Tweleve pigs (28 ± 2 kg) were randomly assigned to two groups: Group I (non-arrested with compressions) (n = 6); Group II (arrested with CPR and defibrillation) (n = 6). Hemodynamic parameters and POP were collected and analyzed. POP was analyzed using both a time domain method and a frequency domain method. In Group I, when compressions were carried out on subjects with a spontaneous circulation, a hybrid fluctuation or “envelope” phenomenon appeared in the time domain method and a “double” or “fusion” peak appeared in the frequency domain method. In Group II, after the period of ventricular fibrillation was induced, the POP waveform disappeared. With compressions, POP showed a regular compression wave. After defibrillation, ROSC, and continued compressions, a hybrid fluctuation or “envelope” phenomenon appeared in the time domain method and a “double” or “fusion” peak appeared in the frequency domain method, similar to Group I. Analysis of POP using the time and frequency domain methods could be used to identify ROSC during CPR.
关键词： Cardiopulmonary resuscitation,Cardiac arrest,Pulse oximetry plethysmographic waveform,Identification,Return of spontaneous circulation
更新于2025-09-10 09:29:36
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Comparison of oxygen saturation measured by pulse oximetry and arterial blood gas analysis in neonates
摘要： Background Arterial blood gas is usually beneficial to discern the nature of gas exchange disturbances, the effectiveness of compensation, and is required for adequate management. Although PaO2 is the standard measurement of blood oxygenation, oxygen saturation measured by pulse oximetry (SapO2) is now a customary noninvasive assessment of blood oxygenation in newborn infants. Objective To compare oxygen saturation measured by pulse oximetry (SapO2) and arterial blood gas (SaO2), its correlation with other variables, and to predict arterial partial pressure of oxygen (PaO2) based on SapO2 values. Methods A cross sectional study was conducted on all neonates admitted to Pediatric Intensive Care Unit (PICU) during February 2001 to May 2002. Neonates were excluded if they had impaired peripheral perfusion and/or congenital heart defects. Paired t-test was used to compare SapO2 with SaO2. Correlation between two quantitative data was performed using Pearson’s correlation. Regression analysis was used to predict PaO2 based on SapO2 values. Results Thirty neonates were included in this study. The difference between SaO2 and SapO2 was significant. There were significant positive correlations between heart rate /pulse rate and TCO2, HCO3; respiratory rate and TCO2, HCO3, base excess (BE); core temperature and HCO3, BE; surface temperature and pH, TCO2, HCO3, BE; SapO2 and pH, PaO2; and significant negative correlation between SapO2 and PaCO2; the correlations were weak. The linear regression equation to predict PaO2 based on SapO2 values was PaO2 = -79.828 + 1.912 SapO2. Conclusion Pulse oximetry could not be used in place of arterial blood gas analysis available for clinical purpose [Paediatr Indones 2003;43:211-215].
关键词： arterial oxygen saturation,pulse oximetry,arterial blood gas analysis,neonates
更新于2025-09-10 09:29:36
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The use of pulse oximeter in hemodynamic assessment
摘要： Objective: Identify and analyze the scientific literature on pulse oximeter with plethysmograph for assessing hemodynamic perfusion. Method: this is an integrative literature review, conducted in January and February 2012 on the Virtual Health Library. Studies published from 2000 to 2011 were selected. Results: after evaluating titles, 24 articles were selected for reading of the abstracts; 17 articles were excluded for not addressing the issue at stake, something which resulted in the inclusion of 7 articles in the sample. Conclusion: nursing care and multidisciplinary team care for the patient using pulse oximeter with plethysmograph may associate non-invasive parameters for hemodynamic assessment of perfusion in everyday clinical practice. Descriptors: Oximetry, Perfusion, Hemodynamics, Nursing.
关键词： Oximetry,Perfusion,Nursing,Hemodynamics
更新于2025-09-10 09:29:36
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Retinal metabolic and structural alterations in response to aflibercept treatment in neovascular age‐related macular degeneration
摘要： Purpose: Non-invasive retinal markers of disease activity could pave the way for individualized treatment in neovascular age-related macular degeneration (nAMD). We aimed to evaluate if retinal vascular oxygen saturation and calibres could predict the initial treatment response after a loading phase of intravitreal a?ibercept in nAMD. Method: A total of 149 eyes were included (nAMD, n = 76; dry AMD, n = 30; normal eyes n = 43). Of these, 57 treatment-na€?ve eyes with nAMD received three monthly injections with 2.0 mg a?ibercept and were subsequently strati?ed according to functional and structural response according to development in best-corrected visual acuity and macular retinal thickness. The retinal vascular oxygen saturation and calibres were measured prior to treatment and 1 month after the third injection. Results: Patients with nAMD and dry AMD had higher retinal arteriolar oxygen saturation as compared to normal eyes (94.3% versus 95.2% versus 92.6%, p = 0.04). Thirty-nine (68.4%) and 12 (21.1%) eyes with nAMD were functional and structural responders. After the loading phase, structural nonresponders developed a higher retinal arteriolar (95.3% versus 93.3%, p = 0.03) and venular (64.7% versus 59.4%, p = 0.02) oxygen saturation, and responders developed a lower retinal arteriolar calibre (118.0 versus 114.3 lm, p < 0.01). In a multiple logistic regression model, increasing retinal venular oxygen saturation associated with a negative structural treatment outcome (odds ratio 1.17 for each 1% increment after the loading phase, 95% con?dence interval 1.01–1.36, p = 0.03). Conclusion: Changes in the retinal venular oxygen saturation associate independently with initial treatment response in nAMD, but functional and structural retinal measurements prior to treatment could not predict the treatment response.
关键词： a?ibercept,retinal vascular calibre,disease activity,neovascular age-related macular degeneration,retinal oximetry,choroidal neovascularization
更新于2025-09-09 09:28:46