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A novel “turn-on” mitochondria-targeting near-infrared fluorescent probe for determination and bioimaging cellular hydrogen sulfide
摘要： Hydrogen sulfide (H2S) has been regarded as an important gas transmitter playing vital role in cytoprotective processes and redox signaling. It is very meaningful to monitor and analyze it in biosystem for obtaining important physiological and pathological information. Despite numerous fluorescent probes for cellular H2S have been reported in past decades, only a few have capability to detect mitochondrial H2S with near-infrared (NIR) emission. Therefore, a new mitochondria-targeting NIR fluorescent probe (Mito-NSH) for detection of cellular H2S was developed by introducing 2,4-dinitrophenyl ether into a novel dye (Mito-NOH). A large "turn-on" NIR fluorescence response was obtained due to thiolysis of ether to hydroxyl group when Mito-NSH was treated with NaHS. Moreover, Mito-NSH could quantitatively detect H2S at concentration ranging from 0 to 30 μM with a detection limit of 68.2 nM, and it exerts some superior optical properties, such as large stokes shift (107 nm), highly selectively mitochondria location, fast response and high selectivity to H2S. More impressively, it was successfully applied to imaging exogenous and endogenously generated H2S in living HeLa cells via confocal fluorescence microscopy.
关键词： Fast response,NIR fluorescent probe,"Turn-on" response,Hydrogen sulfide,Mitochondria-targeting
更新于2025-09-23 15:23:52
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A rhodamine-deoxylactam based fluorescent probe for fast and selective detection of nitric oxide in living cells
摘要： Nitric oxide (NO) plays vital roles in many physiological process and is closely related to many diseases. So far, a number of fluorescent probes have been constructed for the detection of NO successfully. However, the probes still suffer from long-time reaction and limited selectivity. Herein, a fluorescent probe named dRB-OPD is synthesized and used to recognize NO. The probe contains a deoxy-rhodamine B as fluorophore and o-phenylenediamino as reaction site. dRB-OPD shows fast response to NO within 40 seconds with 170-fold fluorescence enhancement. Moreover, the probe shows high selectivity towards NO over dehydroascorbic acid (DHA), ascorbic acid (AA), and methylglyoxal (MGO). Particularly, the probe can avoid the serious interference from cysteine (Cys) found in the rhodamine lactam-based fluorescent NO probes (RB-OPD). In addition, the probe is applied for the detection of exogenous and endogenous NO in the HepG2 and RAW 264.7 cells with satisfactory results.
关键词： Cell imaging,Fluorescent probe,Nitric oxide,High selectivity,Fast response
更新于2025-09-23 15:22:29
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Low-Power-Operating 3C-SiC Ultraviolet Photodetector fora?￡Elevated Temperature Applications
摘要： This work demonstrates the systematic investigation of the effects of high temperature on key performance parameters including speed, sensitivity, stability, and repeatability of a 3C-SiC/Si ultraviolet (UV) photodetector (PD) at various operating temperatures ranging from 50°C to 200°C. The device with very low dark current (≈ 0.08 pA) exhibited high sensitivity of 4466 and fast rise and decay times of 0.34 s and 0.30 s at 50°C to exposure of 254 nm UV light at a bias voltage of 20 V. Additionally, the device showed very good performance at a low operating voltage of 0.5 V and high temperature of 200°C, with a rise time of 2.68 s and decay time of 1.44 s, while maintaining good stability and repeatability. The slight decrease in performance (sensitivity from 4466 to 932) at 200°C was attributed to the increase in lattice scattering at elevated temperatures, leading to a decrease in carrier mobility. Moreover, the device was fabricated using a very cost-effective process flow. Consequently, this study can contribute to the development of low-power, fast, highly sensitive, and cost-effective 3C-SiC UVPDs for use in high-temperature photonic applications.
关键词： fast response,high sensitivity,High-temperature UVPD,low-voltage operation,3C-SiC
更新于2025-09-23 15:21:01
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Faceta??Dependent, Fast Response, and Broadband Photodetector Based on Highly Stable Alla??Inorganic CsCu <sub/>2</sub> I <sub/>3</sub> Single Crystal with 1D Electronic Structure
摘要： Low-dimensional metal halides at molecular level, which feature strong quantum confinement effects from intrinsic structure, are emerging as ideal candidates in optoelectronic fields. However, developing stable and nontoxic metal halides still remains a great challenge. Herein, for the first time, high-crystalline and highly stable CsCu2I3 single crystal, which is acquired by a low-cost antisolvent vapor assisted method, is successfully developed to construct high-speed (trise/tdecay = 0.19 ms/14.7 ms) and UV-to-visible broadband (300–700 nm) photodetector, outperforming most reported photodetectors based on individual all-inorganic lead-free metal halides. Intriguingly, facet-dependent photoresponse is observed for CsCu2I3 single crystal, whose morphology consists of {010}, {110}, and {021} crystal planes. The on–off ratio of {010} crystal plane is higher than that of {110} crystal plane, mainly owing to lower dark current. Furthermore, photogenerated electrons are localized in twofold chains created by [CuI4] tetrahedra, leading to relatively small effective mass and fast transport mobility along the 1D transport pathway. Anisotropic carrier transport characteristic is related to stronger confinement and higher electron density for {110} crystal planes. This work not only demonstrates the great potential of CsCu2I3 single crystal in high-performance optoelectronics, but also gives insights into 1D electronic structure associated with fast photoresponse and high anisotropy.
关键词： photodetectors,facet-dependent photoresponse,1D electronic structures,highly stable,fast response
更新于2025-09-23 15:21:01
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Fast response fluorogenic probe for visualizing hypochlorite in living cells and Zebrafishes
摘要： A novel fast response and visible fluorogenic probe (D1) for monitoring hypochlorite (ClO?) has been developed based on specific ClO? removal of a C=N bond. The response of the probe to ClO? showed increases linearly, and the fluorescence intensity heighten about 25 times. D1 responses to ClO? were observed with high selectivity and sensitivity within 10 s by naked eyes. D1 can not only detect the level of hypochlorite in vitro such as urine, but also monitoring hypochlorite content in extremely cold condition as low as -78oC. Meanwhile, the good biocompatibility guaranteed the use of D1 to detect intracellular ClO? under confocal microscopy. Moreover, D1 has been successfully applied to monitor the exogenous and endogenous ClO? in Zebrafishes with fluorescence imaging.
关键词： Zebrafishes,live cell imaging,hypochlorite,fast response,fluorogenic probe
更新于2025-09-23 15:21:01
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Fast-Response and Self-Powered Cu <sub/>2</sub> O/ZnO Nanorods Heterojunction UV-Visible (570 nm) Photodetectors
摘要： A fast, self-powered photodetector (PD) capable of UV to visible (570 nm) sensing based on the p-Cu2O/n-ZnO nanorods (NRs) heterostructure is reported. The PD shows a spectral response range from 380 nm to 570 nm, which is suitable for ambient light sensing applications. The PD exhibits good rectifying characteristics with a low leakage current and a low turn-on voltage of ～0.3 V. The responsivities of the self-powered PD are 0.24 A W?1 and 0.06 A W?1 at 380 and 450 nm, respectively. The rise/recovery time of the PD are 0.02/0.03 s and 0.01/0.02 s for UV (370 nm) and visible light (450 nm), respectively. Upon UV light illumination, the long, persistent photocurrent (or recovery time) caused by ZnO NRs can be eliminated using the self-powered mode.
关键词： fast-response,p-Cu2O/n-ZnO nanorods heterostructure,self-powered photodetector,UV-Visible sensing
更新于2025-09-23 15:19:57
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Highly sensitive, broadband, fast response organic photodetectors based on semi-tandem structure
摘要： Solution-processed organic photodetectors (OPDs) simultaneously integrating high performance by solution-processability. The semi-tandem structure directly superimposes two active layers with complementary absorption spectra, achieving a broad spectral response of 300-1000 nm. It provides a detection covering from ultraviolet to near-infrared range, while the external quantum efficiency in the spectral range of 550 nm to 950 nm retains 70 %. The high electron and hole injection barriers enable a dark current density as low as 6.51×10-5 mA cm-2 at -0.1 V, resulting in a noise current of 3.91×10-13 A Hz-1/2 at 70 Hz, which is nearly three times lower than single-junction photodetectors. Encouragingly, the device response speed is improved by suppressing the resistance-capacitance time constant of the device employing semi-tandem structure induced capacitance decreasing. The state-of-the-art OPDs contribute to the response time of 26.27 ns, which is the fastest one in OPDs to the best of our knowledge. We believe that the semi-tandem structures provide a new approach to achieving high-performance photodetectors integrating fast, sensitive and broadband response.
关键词： broadband,ultra-fast response,Organic photodetectors,semi-tandem structure
更新于2025-09-23 15:19:57
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Growth of monolayer and bilayer MoS2 through the solution precursor for high-performance photodetectors
摘要： Various studies suggest that the performances of TMDs are largely thickness dependent. In this paper, we develop a chemical vapor deposition method to synthesis monolayer and bilayer MoS2 flakes with a solution precursor. The MoS2 phototransistors were prepared to investigate their optoelectronic performance. The MoS2 photodetectors exhibit high detectivity of 2.44×1011 and a fast response/recovery time of 97 ms/291 ms. The photoresponsivity of bilayer MoS2 flakes was found up to 7160 A W?1. Our research will pave a pathway to control the layer numbers of other TMDs nanostructures, expand the application of high performance 2D materials.
关键词： Fast response/recovery time,Chemical vapor deposition,H8MoN2O4,Liquid precursor,Control of the layer numbers,High detectivity
更新于2025-09-23 15:19:57
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SbSI microrod based flexible photodetectors
摘要： In this paper, SbSI microrods is prepared by using a simple hydrothermal method via sulfur powder as sulfur source. The as-synthesized SbSI microrods with sulfur as sulfur powder source has better flexibility than that of SbSI with thiourea as sulfur source due to decreasing force constant between Sb and S atom. SbSI microrod based flexible photodetectors exhibit higher specific detectivity of up to 5.43×1010 Jones, fast response speed (rise time and fall time of 61 ms and 128 ms, respectively) and also show low dark current less than 50 pA. Especially, the photoresponse performance of the SbSI microrod based flexible photodetectors are almost unchanged after different bending curvatures and bending times more than 2000 times.
关键词： higher specific detectivity,fast response speed,SbSI microrods,flexible photodetector
更新于2025-09-23 15:19:57
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Asymmetric Contact Induced Self-Powered 2D In2S3 Photodetector towards High-Sensitivity and Fast-Response
摘要： Self-powered photodetectors have triggered extensive attention in recent years due to the advantages of high sensitivity, fast response, low power consumption, high level of integration and wireless operation. To date, most self-powered photodetectors are implemented through the construction of either heterostructures or asymmetric electrode material contact, which are complex to process and costly to produce. Herein, for the first time, we achieve self-powered operation by adopting geometrical asymmetry in the device architecture, where a triangular non-layered 2D In2S3 flake with asymmetric contact is combined with traditional photogating effect. Importantly, the device achieves excellent photoresponsivity (740 mA/W), high detectivity (1.56 × 1010 Jones), and fast response time (9/10 ms) under zero bias. Furthermore, the asymmetric In2S3/Si photodetector manifests long-term stability. Even after 1000 cycles of operation, the asymmetric In2S3/Si device displays negligible performance degradation. In sum, the above results highlight a novel route towards self-powered photodetectors with high performance, simple processing and structure in the future.
关键词： high sensitivity,fast response,asymmetric contact,Self-powered photodetectors,2D In2S3,photogating effect
更新于2025-09-19 17:13:59