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Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis
摘要： Introduction: Optic disc hypoplasia is a common feature in fetal alcohol syndrome. Thus, we aimed to evaluate the optic disc morphology changes and the peripapillary retinal nerve fiber layer thickness in these patients. Material and Methods: We performed spectral-domain optical coherence tomography in a cohort of 11 patients (22 eyes) with fetal alcohol syndrome and in an age-matched control group. We evaluated optic nerve head parameters (optic disc area and diameter, rim area, cup/disc horizontal and vertical ratios) and peripapillary retinal nerve fiber layer thickness. Results: Mean optic disc area, rim area and optic disc diameter were, respectively, in fetal alcohol syndrome patients and control subjects: 1.540 ± 0.268 and 1.748 ± 0.326 mm2; 1.205 ± 0.286 and 1.461 ± 0.314 mm2; 1.417 ± 0.124 and 1.501 ± 0.148 mm (p < 0.05). We found no significant differences between groups for cup/disc ratios. Mean retinal nerve fiber layer thickness was significantly lower in fetal alcohol syndrome patients (90.500 ± 9.344 μm) as compared to controls (111.000 ± 7.855 μm) (p < 0.0001). Analysis showed a significant decrease in retinal nerve fiber layer thickness for the superior, inferior and nasal quadrants (p < 0.005). The temporal quadrant showed no significant differences. Discussion: Optic disc area, rim area and optic disc diameters were significantly reduced in fetal alcohol syndrome patients. Although mean peripapillary retinal nerve fiber layer thickness was decreased, the temporal quadrant was spared. Conclusion: In addition to a smaller optic disc area/ diameter and rim area, we found a heterogeneous peripapillary retinal nerve fiber layer thickness loss in fetal alcohol syndrome patients with sparing of the temporal quadrant. Spectral-domain optical coherence tomography may be useful to determine the presence of fetal alcohol syndrome status.
关键词： Retina,Fetal Alcohol Spectrum Disorders,Optic Nerve Diseases,Nerve Fibers
更新于2025-09-23 15:23:52
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Patterns of Subsequent Progression of Localized Retinal Nerve Fiber Layer Defects on Red-free Fundus Photographs in Normal-tension Glaucoma
摘要： Purpose: To investigate patterns of subsequent progression of localized retinal nerve fiber layer (RNFL) defects and to quantify the extent of progression in normal-tension glaucoma (NTG) patients. Methods: Thirty-three eyes of 33 consecutive NTG patients who had shown continuous progression of localized RNFL defect on serial red-free fundus photographs were selected for the study. Patterns of subsequent progression of localized RNFL defects were categorized, and extents of progression were quantified. Serial evaluations of disc stereophotographs and visual fields were also performed to detect progression. Results: The most common pattern was continuous widening of the defect towards the macula (n = 11, 33.3%) followed by sharpening of the defect border after widening of the defect towards the macula (n = 5, 15.2%), continuous widening of the defect away from the macula (n = 2, 6.1%), and deepening of the defect after appearance of a new defect (n = 2, 6.1%). Four eyes (12.1%) simultaneously showed two patterns of subsequent progression. In 13 eyes that showed continuous widening of the defect, subsequent angular widening towards the macula and away from the macula were 9.2 ± 6.0° (range, 1.1° to 24.4°; n = 11) and 5.2 ± 4.9° (range, 0.3° to 11.3°; n = 2), respectively. Thirty-two eyes showed no progression of optic disc cupping. Out of the 21 eyes in which Humphrey central 30-2 threshold visual field tests were performed after progression of RNFL defects, 15 eyes showed no deterioration in the visual field. Conclusions: There were nine patterns of subsequent progression of localized RNFL defects. Among them, continuous RNFL loss proceeding temporally was the most common one. Initial progression of the defect proceeded temporally, especially in the defect located at the inferior fundus, might be at a risk of further RNFL loss temporally.
关键词： Nerve fibers,Low tension glaucoma,Progression
更新于2025-09-23 15:22:29
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[IEEE 2018 IEEE International Systems Engineering Symposium (ISSE) - Rome, Italy (2018.10.1-2018.10.3)] 2018 IEEE International Systems Engineering Symposium (ISSE) - Implementation of support tools for the presumptive diagnosis of Glaucoma through identification and processing of medical images of the human eye
摘要： In medicine, the diagnosis of diseases by means of image processing has had great acceptability and credibility, which is why it has been able to explore in depth the theme, taking advantage of mainly which is a non-invasive method within the clinical study. Glaucoma is considered as a group of diseases that damages the optic nerve to the point of causing blindness in the eye, with the disadvantage of in most cases do not exhibit early symptoms. Through this work, the processing biomedical images to locate the parameters considered most relevant within images obtained from the back of the eye to make the determination of the existence or not of Glaucoma, a disease that mainly affects physically the dimensions and proportions of the cup and the optical disc. It gets the value of the reason cup/disc and is additional to the characteristics of the rule ISNT, both parameters considered of great importance in the diagnosis of glaucoma. The results obtained serve as a tool to support the specialist in ophthalmology and optometry in conjunction with a presumptive diagnosis of glaucoma, this way it looks for the early detection and prevention of this disease.
关键词： ISNT,visual field,cup-disc,Glaucoma,nerve fibers,image processing,optic nerve
更新于2025-09-09 09:28:46
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Effectiveness of Glaucoma Diagnostic Parameters from Spectral Domain-Optical Coherence Tomography of Myopic Patients
摘要： 目的：目前频域光学相干成像（SD?OCT）可作为青光眼诊断的新工具。因此本文评价了SD?OCT所提供的青光眼诊断参数在不同屈光度近视患者中的诊断能力。 方法：横断面研究。共有248例受试者（248眼）入选。包括早期开角型青光眼组51，正常人组79例（±0.50D之内），低度近视组47例（?0.50 D to ?3.00 D（不包括）），中度近视组43例（?3.00 D to ?6.00 D（不包括）），高度近视组28例（≤?6.00 D）。所有受试者均行眼科常规检查及Humphrey 视野计、SD?OCT检查，将OCT检查所获得的视网膜神经纤维层(RNFL)和节细胞复合体（GCC））的相关参数进行统计学分析，分别绘制受试者操作曲线（ROC）并计算曲线下面积（AUC）。 结果：AUC结果如下：正常人、低度近视眼组的AUC最佳参数均为下方、颞下方RNFL厚度（AUC均﹥0.94），而中度近视、高度近视组的最佳参数均为颞下方参数（AUC分别为0.926，0.896），而中度近视组下方参数的AUC较?。?.864）排在所有RNFL参数的第15位。对文献中公认的诊断青光眼能力强的参数（下方、颞下方、颞上方）进行进一步分析，当灵敏度为85%时，这些参数在正视眼、低度近视眼组的特异度较高，均大于80%，而在中度近视、高度近视组特异度均较低，约在20%～60%。根据机器数据库所得绿色部分在高度近视组也较其他组少（P < 0.05）。 结论：SD?OCT的青光眼诊断参数在应用于中高度近视眼时的诊断能力较弱，特异度明显偏低，对中高度近视者进行青光眼的诊断时需综合分析。同时建议SD?OCT的正常人数据库应针对不同屈光度进行补充完善。
关键词： Glaucoma,Retina,Myopia,Nerve Fibers,Open Angle
更新于2025-09-04 15:30:14