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Blue LED light-driven photoelectrocatalytic removal of naproxen from water: Kinetics and primary by-products
摘要： Here, we demonstrate the viability of a ZnO/TiO2/Ag2Se thin-film composite synthesized on FTO to degrade the drug naproxen in aqueous solutions by visible-light photoelectrocatalysis (PEC). The experiments were made with 100 mL of solutions containing 5 mg L-1 drug and 50 mM Na2SO4 at natural pH, using a cell equipped with a Pt wire as cathode and the composite as photoanode exposed to a 36 W blue LED lamp. Total degradation was achieved after 210 min of electrolysis at anodic potential of +1.0 V/Ag|AgCl. This resulted from the oxidative action of hydroxyl radicals formed via direct anodic water discharge and through mediated water oxidation by photogenerated holes. The degradation rate decreased at higher naproxen concentration, but the treatment efficiency became higher due the deceleration of the parasitic reactions involving hydroxyl radicals. In chloride medium, the photoanode showed a large ability to produce active chlorine, which contributed to the oxidation of the target molecule. LC-QToF-MS analysis of treated solutions revealed the generation of four primary naphthalenic by-products, from which the initial degradation route of naproxen is proposed.
关键词： Photoelectrocatalysis,Water treatment,Oxidation by-products,Blue LED light,Pharmaceutical residue
更新于2025-09-23 15:21:01
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The Strong Inhibitory Effect of Combining Anti-Cancer Drugs AT406 and Rocaglamide with Blue LED Irradiation on Colorectal Cancer Cells
摘要： There is still no satisfying method to treat colorectal cancer (CRC) currently. Inspired by cocktail therapy, the combination of 465 nm blue LED irradiation and two multi-target anticancer agents AT406 and Rocaglamide has been investigated for a revolutionary way to treat colorectal cancer cells in vitro. It showed a strong inhibitory effect on colorectal cancer cells, and its side effects on human normal cells are negligible. When applied to HCT116 cells, it can achieve an apoptotic rate up to 95%. It is also seen to significantly inhibit proliferation of HT29 cells. Furthermore, little to no cell inhibition or damage of normal MRC-5 cells were seen after treatment. The combination of blue LED irradiation and two anti-cancer drugs causes apoptosis of colorectal cancer cells by activating the apoptotic pathway, inhibiting autophagy and proliferation pathways as well as the production of reactive oxygen species (ROS).
关键词： Multi-targeted anticancer drugs,Colorectal cancer,Inhibitory effect,Blue LED irradiation
更新于2025-09-23 15:21:01
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AIP Conference Proceedings [AIP Publishing 3RD INTERNATIONAL CONFERENCE ON CONDENSED MATTER AND APPLIED PHYSICS (ICC-2019) - Bikaner, India (14a??15 October 2019)] 3RD INTERNATIONAL CONFERENCE ON CONDENSED MATTER AND APPLIED PHYSICS (ICC-2019) - Effect of polarization field and Auger recombination on internal quantum efficiency of InGaN/GaN blue LED
摘要： InxGa1-x N/GaN blue LEDs faces significant efficiency droop issue. The causes of efficiency droop are Shockley Read Hall recombination (SRH), Auger recombination (AR), carrier delocalization and electron leakage. The SRH, Auger and electron leakage are functions of carrier concentration and temperature. InGaN/GaN superlattice has polarization electric field at interface. In this work we explore effect of polarization electric field on efficiency droop. It is shown that polarization field enhances Auger coefficient resulting in more droop in internal quantum efficiency of blue LED. Thus, for improvement in efficiency, polarization field required to be minimized which requires growth of the material in m- plane instead of c-plane.
关键词： efficiency droop,polarization electric field,Auger recombination,blue LED,InGaN/GaN
更新于2025-09-23 15:21:01
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Bumblebees land remarkably well in red-blue greenhouse LED light conditions
摘要： Red-blue emitting LEDs have recently been introduced in greenhouses to optimize plant growth. However, this spectrum may negatively affect the performance of bumblebees used for pollination, because the visual system of bumblebees is more sensitive to green light than to red-blue light. We used high-speed stereoscopic videography to 3D track and compare landing manoeuvres of Bombus terrestris bumblebees in red-blue light and in regular, broad-spectrum white light. In both conditions, the landing approaches were interspersed by one or several hover phases, finally followed by leg extension and touchdown. The time between leg extension and touchdown was 25% (0.05 s) longer in red-blue light than in white light, caused by a more tortuous flight path in red-blue light. However, the total landing duration, specified as the time between the first hover phase and touchdown, did not differ between the light conditions. This suggests that the negative effects of red-blue light on the landing manoeuvre are confined to the final phase of the landing.
关键词： landing,red-blue LED light,pollination,bumblebees,greenhouse
更新于2025-09-23 15:21:01
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Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells
摘要： Exposure to blue light from light-emitting diodes (LEDs) is a source of damage for human eyes in today’s modern life. Although it is well known that blue light can cause cellular damage and death, the molecular mechanism underlying this is still not fully understood. Here, we demonstrated that exposure to blue LED light increased lysosome levels and perinuclear cluster formation in 661W murine photoreceptor-derived cells. Irradiation with blue LED light promoted the nuclear transport of transcription factor EB (TFEB) and a subsequent increase in lysosomal-related gene expression. Moreover, blue LED light induced morphological changes in lysosomal structure and lysosomal membrane permeabilization (LMP). These effects were suppressed by an antioxidant, N-acetylcysteine (NAC). Finally, a calcium ion chelator, BAPTA-AM, attenuated blue LED light-induced lysosomal biogenesis and cell death. Taken together, these findings suggest that oxidative stress under blue LED light increases lysosome levels via the TFEB pathway in a calcium-dependent manner, resulting in the accumulation of damaged lysosomes and subsequently lysosomal cell death. Our results imply that lysosomal homeostasis plays a key role in the maintenance of eye function and the progression of retinal diseases.
关键词： TFEB,Blue LED light,Calcium,Lysosome biogenesis,Oxidative stress,Lysosomal membrane permeabilization
更新于2025-09-23 15:21:01
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Diverse autophagy and apoptosis in myeloid leukemia cells induced by 20(s)-GRh2 and blue LED irradiation
摘要： Autophagy is an important mechanism for cell death regulation. To improve the anticancer effect during the treatment of leukemia and promote the apoptosis of leukemic cells, it is important to define the relationship between autophagy and apoptosis. A key bioactive compound in traditional Chinese medicine, 20(s)-Ginsenoside (GRh2), demonstrated an advancement in leukemia treatment. Blue LED therapy (BL) is a physical treatment method that can induce leukemic cell death. In this study, we tested the effect of 20(s)-GRh2, BL, and their combination (BL–GRh2) on the activation of leukemic cell apoptosis and autophagy. Both treatments, whether used individually or simultaneously, induce apoptosis through the induction of reactive oxygen species (ROS), disrupted mitochondrial membrane potential (MMP) and regulated the expression of apoptosis-related genes and proteins. Furthermore, using western blotting to analyze the autophagy markers LC3B and P62, we detected the activation of autophagy. In cells treated with autophagy inhibitor 3-MA, both autophagy and apoptosis were inhibited, either by BL alone or by BL–GRh2. However, apoptosis in 20(s)-GRh2-treated cells was enhanced. In cells treated with apoptosis suppressor Z-VAD-FMK, autophagy was inhibited in the BL and BL–GRh2-treated cells, although it was enhanced in cells treated with 20(s)-GRh2 alone. Moreover, we observed a stronger induction of apoptosis by BL–GRh2 in myeloid leukemia cells. Our data indicate that autophagy induced by different factors can play diverse roles on the same cells. Our results also indicate that the combination of traditional Chinese medicine with physical therapy may be a new strategy for anti-cancer therapy.
关键词： 20(s)-GRh2,apoptosis,autophagy,leukemia,blue LED therapy
更新于2025-09-16 10:30:52
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Carbon Dots as Promising Green Photocatalyst for Free Radical and ATRP-Based Radical?Photopolymerization with Blue LEDs
摘要： This contribution reports for the first time about the use of carbon dots (CDs) as sensitizer to initiate and activate free radical and controlled radical polymerization based on an ATRP protocol with blue LEDs, respectively. Consideration of diverse heteroatom-doped CDs indicated well-functioning of N-doped CDs as effective photocatalyst and photosensitizer in combination with LEDs emitting either at 405 nm or 470 nm. Initiation of free radical polymerization occurred by combining the CDs with an iodonium or sulfonium salt in tri(propylene glycol) diacrylate. Polymerization of methyl methacrylate (MMA) by photo-induced ATRP was achieved with CDs and ethyl a-bromophenylacetate using Cu(II) as catalyst in the ppm range. The polymers obtained showed temporal control, narrower dispersity ?1.5, and chain-end fidelity. The first order obtained from kinetic slope and ON/OFF experiments additionally approved constant concentration of polymer radicals. No remarkable cytotoxic activity was observed of the CDs underlining their biocompatibility.
关键词： blue LED,free radical photopolymerization,photo-ATRP,cytotoxicity,Carbon dot
更新于2025-09-12 10:27:22
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Carbon Dots as Promising Green Photocatalyst for Free Radical and ATRP‐Based Radical?Photopolymerization with Blue LEDs
摘要： This contribution reports for the first time about the use of carbon dots (CDs) as sensitizer to initiate and activate free radical and controlled radical polymerization based on an ATRP protocol with blue LEDs, respectively. Consideration of diverse heteroatom-doped CDs indicated well-functioning of N-doped CDs as effective photocatalyst and photosensitizer in combination with LEDs emitting either at 405 nm or 470 nm. Initiation of free radical polymerization occurred by combining the CDs with an iodonium or sulfonium salt in tri(propylene glycol) diacrylate. Polymerization of methyl methacrylate (MMA) by photo-induced ATRP was achieved with CDs and ethyl a-bromophenylacetate using Cu(II) as catalyst in the ppm range. The polymers obtained showed temporal control, narrower dispersity ?1.5, and chain-end fidelity. The first order obtained from kinetic slope and ON/OFF experiments additionally approved constant concentration of polymer radicals. No remarkable cytotoxic activity was observed of the CDs underlining their biocompatibility.
关键词： blue LED,free radical photopolymerization,photo-ATRP,cytotoxicity,Carbon dot
更新于2025-09-12 10:27:22
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<i>Candida albicans</i> Sterilization Using a Light-Emitting Diode and Methylene Blue
摘要： Background and aims: Conventional fungal treatment using external medication requires considerable time and effort. We herein examined the basic effect of methylene blue (MB) with sodium bicarbonate (NaHCO3) on Candida albicans sterilization using photodynamic antimicrobial chemotherapy (PACT). Materials and methods: NaHCO3 was added to MB to establish a basic pH. Then, C. albicans was smeared on a medium with basic MB followed by irradiation using a red light-emitting diode (LED) with a wavelength of 660 nm. The applied energy fluencies were 5, 10, 15, and 20 J/cm2. After 48 h of culture, the effects of the intervention were determined according to the fungal growth area. Results: The basic effect appeared at a pH range of 8.6 to 8.9 and at 10 and 15 J/cm2, while the NaHCO3 concentration was between 1% and 2%. Conclusions: Our results suggested that PACT using basic MB was effective for C. albicans sterilization.
关键词： C. albicans,basic effect,methylene blue,LED,PACT,sodium bicarbonate
更新于2025-09-11 14:15:04
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Copper‐Phosphine Supported Fe <sub/>3</sub> O <sub/>4</sub> @SiO <sub/>2</sub> as a Novel Reusable Nanocatalyst‐Catalyzed Tandem Reaction of Indole and Alcohols to Bis(indolyl)methanes under Blue LED Light
摘要： Nano Fe3O4@SiO2@TPP(cid:0) Cu as a novel heterogeneous nano-catalyst was prepared and authenticated by usual analytical and spectroscopic techniques. The prepared Fe3O4@SiO2@TPP(cid:0) Cu was applied to preparation of bis(indolyl) methane derivatives via a three-component reaction of aromatic alcohols with indoles under blue led lights. The advantages of this method are the selective oxidation of alcohols under mild conditions. The recycling studies revealed that catalyst could be easily recovered using an external magnet and reused for five times without significant loss of its catalytic activity.
关键词： Nano Fe3O4@SiO2@TPP(cid:0) Cu,Superparamagnetic nanocatalyst,Oxidation alcohols,Blue LED Light,Bis(indolyl)methanes
更新于2025-09-11 14:15:04