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Fiber-Optic Magnetic Field Sensing Based on Microfiber Knot Resonator with Magnetic Fluid Cladding
摘要： A kind of all-fiber magnetic field sensing structure is proposed and demonstrated here. The sensing element includes a microfiber knot resonator (MKR) cladded with magnetic fluid (MF). The low-index MgF2 slab is adopted as the substrate. The sensitivity increases with the decrease of the MKR ring diameter. The achieved maximum magnetic field sensitivity is 277 pm/mT. The results of this work have the potential to promote the development of magnetically controllable optical devices and the design of ultra-compact cost-effective magnetic field sensors.
关键词： quality factor,finesse,magnetic fluid,microfiber knot resonator
更新于2025-11-28 14:24:03
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Targeting fluorescent nanodiamonds to vascular endothelial growth factor receptors in tumor
摘要： The increased expression of vascular endothelial growth factor (VEGF) and its receptors is associated with angiogenesis in a growing tumor, presenting potential targets for tumor-selective imaging by way of targeted tracers. Though fluorescent tracers are used for targeted in vivo imaging, the lack of photostability and biocompatibility of many current fluorophores hinder their use in several applications involving long-term, continuous imaging. To address these problems, fluorescent nanodiamonds (FNDs), which exhibit infinite photostability and excellent biocompatibility, were explored as fluorophores in tracers for targeting VEGF receptors in growing tumors. To explore FND utility for imaging tumor VEGF receptors, we used click-chemistry to conjugate multiple copies of an engineered single-chain version of VEGF site-specifically derivatized with trans-cyclooctene (scVEGF-TCO) to 140 nm FND. The resulting targeting conjugates, FND-scVEGF, were then tested for functional activity of the scVEGF moieties through biochemical and tissue culture experiments and for selective tumor uptake in Balb/c mice with induced 4T1 carcinoma. We found that FND-scVEGF conjugates retain high affinity to VEGF receptors in cell culture experiments and observed preferential accumulation of FND-scVEGF in tumors relative to untargeted FND. Microspectroscopy provided unambiguous determination of FND within tissue by way of the unique spectral shape of nitrogen-vacancy induced fluorescence. These results validate and invite the use of targeted FND for diagnostic imaging and encourage further optimization of FND for fluorescence brightness.
关键词： Vascular Endothelial Growth Factor,Oncology,Targeted Fluorescence Imaging,Nanodiamond,Angiogenesis
更新于2025-11-21 11:24:58
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Zwitterionic near-infrared fluorophore-conjugated epidermal growth factor for fast, real-time, and target-cell-specific cancer imaging
摘要： Epidermal growth factor receptor (EGFR) is overexpressed in many types of cancers, which is associated with metastatic potential and poor prognosis in cancer patients. Therefore, development of EGFR-targeted sensitive imaging probes has been a challenge in tumor targeting, image-guided cancer surgery, patient-selective anti-EGFR therapy, and efficient targeted therapies. Methods: We synthesized a zwitterionic near-infrared fluorophore (ATTO655)-conjugated epidermal growth factor (EGF) as a novel activatable molecular probe. Fluorescence OFF/ON property and EGFR-targeting specificity of EGF-ATTO655 as well as its utility in real-time near-infrared (NIR) fluorescence imaging of EGFR-positive cancers were evaluated using in vitro and in vivo studies. Results: When conjugated to EGF, the fluorescence of ATTO655 quenched efficiently by photo-induced electron transfer (PET) mechanism between the conjugated dyes and nearby amino acid quenchers (tryptophan/tyrosine residues), which was stably maintained at physiological pH and in the presence of serum for at least 17 h. The fluorescence of EGF-ATTO655 turned on by receptor-mediated endocytosis and subsequent disintegration of EGF in EGFR-positive A431 cancer cells, thereby enabling specific and real-time fluorescence imaging of EGFR-positive cancer cells. Consequently, EGFR-positive tumors could be clearly visualized 3 h post-injection with a significantly high tumor-to-background ratio (TBR = 6.37). Conclusion: This PET mechanism-based OFF/ON type of EGF probe showed great potential for rapid, real-time, and target-cell-specific imaging of EGFR-overexpressing cancers in vitro and in vivo.
关键词： photo-induced electron transfer,Epidermal growth factor,real-time cancer imaging,tumor-specific targeting
更新于2025-11-21 11:24:58
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Translating chemometric analysis into physiological insights from in vivo confocal Raman spectroscopy of the human stratum corneum
摘要： The superficial layer of the skin, the stratum corneum (SC), consists of corneocytes surrounded by lipid regions and acts as a protective barrier for the body against water loss, toxic agents and microorganisms. As most substances permeate the stratum corneum through the lipid regions, lipid organization is considered crucial for the skin barrier function. Here, we investigate the potential of in vivo confocal Raman spectroscopy to describe the composition and organization of the SC. Confocal Raman spectroscopy is finding increasing use in the characterization of skin in biomedical, pharmaceutical and cosmetic applications. In this work, we analyze the spectra using chemometric methods and obtain principal components that correspond to the primary skin constituents: protein (keratin), natural moisturizing factor (NMF), water and lipid contributions in both ordered (orthorhombic) and disordered structural organization. By identifying these important components of the SC, these results highlight the utility of this in vivo, non-invasive, and depth resolved tool at the forefront of skin research.
关键词： Skin barrier,Natural moisturizing factor,Multivariate curve resolution,Keratin,Lipid organization
更新于2025-11-14 15:16:37
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Evaluation of solar factor using spectral analysis for CdTe photovoltaic glazing
摘要： Solar and luminous light transmission control using Cadmium Telluride (CdTe) based PV glazing systems (15cm × 15 cm × 0.6 cm) were evaluated in this work. Indoor spectral characterisation showed that average solar transmission for investigated three different CdTe glazing systems were 5.77% (CdTe1), 9.54% (CdTe2) and 12.34% (CdTe3). Spectral behaviour of reflections in the range of solar and visible wavelengths was similar for these three different transparent CdTe glazing. Near infrared (NIR) reflection was higher compared to luminous reflection after 1500 nm for all three glazing systems. Solar factor (SF) for CdTe1, CdTe2 and CdTe3 glazing were 0.23, 0.28, 0.26. CdTe3 is the best candidate for glazing application as it has 113% higher luminous transmission while SF only increases by 21% compared to CdTe1.
关键词： transmission,reflection,solar factor,glazing,Cadmium Telluride (CdTe),thin film solar cell
更新于2025-10-22 19:40:53
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Investigation of semi- transparent dye-sensitized solar cells for fenestration integration
摘要： For any particular location glazing transmission varies with season and time of day. Thus, glazing transmission angular behaviour is more crucial than single glazing transmittance value for building energy simulation and design. In this work, the spectral behaviour of the dye-sensitized solar cell (DSSC) glazing with three different transparencies are studied. Transmittance of the devices are measured after 2 years to understand the effects of device stability on DSSC glazing applications. The solar factor for the devices is calculated for different light incident angles for a whole year at a particular location. The correlation between clearness index and DSSC transmittance is also studied. Finally, glare analysis is performed for all the devices on a sunny day, intermittent day and overcast day, and is also compared with double glazing. It is found that the 37% transparent DSSC glazing leads to a greater reduction in disturbing glare by 21% compared to double glazing on a clear sunny day. All the above results suggest that DSSC glazings could be productively used for fenestration integration in buildings.
关键词： DSSC,clearness index,daylight glare,glazing,solar factor,angular transmission
更新于2025-10-22 19:40:53
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[IEEE 2018 Seventh Balkan Conference on Lighting (BalkanLight) - Varna (2018.9.20-2018.9.22)] 2018 Seventh Balkan Conference on Lighting (BalkanLight) - Comparison of Experimental and Simulation Data for Daylighting
摘要： The paper detailed information about experimental results, obtained for the Daylight Factor (DF) of an educational facility. The experimental data obtained is compared to computational results, given by different software products for lighting calculations. The correlation between the measured and the simulated data is estimated.
关键词： daylight factor,daylighting,simulation software,daylight factor profile
更新于2025-09-23 15:23:52
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High Breakdown Strength Schottky Diodes Made from Electrodeposited ZnO for Power Electronics Applications
摘要： The synthesis of ZnO films by optimized electrodeposition led to the achievement of a critical electric field of 800 kV/cm. This value, which is 2 to 3 times higher than in monocrystalline silicon, was derived from a vertical Schottky diode application of columnar-structured ZnO films electrodeposited on platinum. The device exhibited a free carrier concentration of 2.5 × 10^15 cm^-3, a rectification ratio of 3 × 10^8 and an ideality factor of 1.10, a value uncommonly obtained in solution-processed ZnO. High breakdown strength and high thickness capability make this environment-friendly process a serious option for power electronics and energy-harvesting.
关键词： breakdown voltage,electrodeposition,zinc oxide,critical electric field,solution-processed,Schottky diode,power diode,ideality factor
更新于2025-09-23 15:23:52
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Metasurface for Constructing a Stable High- <i>Q</i> Plano-Planar Open Cavity
摘要： Traditional open cavities are constructed by planar or concave mirrors. A Fabry–Pérot (FP) cavity is convenient to integrate and fabricate, but highly sensitive to the parallelism of the end mirrors. In contrast, a concave cavity is more stable and possesses a lower leaky rate, but the curved geometry brings inconvenience. Here, it is suggested that a planar meta-cavity can simultaneously possess the advantages of both of the above open cavities by using a metasurface to create a planar meta-mirror that mimics the behavior of a concave mirror. For demonstration, a microwave meta-cavity is constructed, whose meta-mirror consists of subwavelength ceramic blocks on a metal substrate. Compared to an FP cavity, the meta-cavity is more robust against the alignment error of the end mirrors, and 15-fold enhancement of the quality factor is observed numerically. Experimental results are in good agreement with the simulated results. The suggested method may be extended to work in high frequency ranges. This work would support the planarization and miniaturization of an open cavity and may also increase the functionality.
关键词： open cavities,cavity stability,high quality factor,metasurfaces
更新于2025-09-23 15:23:52
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Low-phase noise 8.22 GHz GaN HEMT oscillator using a feedback multi-path transformer
摘要： This article designs a low-phase noise 8.22 GHz GaN high electron-mobility transistor (HEMT) oscillator in the WIN 0.25 μm GaN HEMT process. The oscillator uses a HEMT amplifier with a transformer as the feedback network. The transformer uses a 3-path secondary inductor and a single-path primary inductor. The GaN oscillator consumes the power 4.328 mW and generates a signal at 8.22 GHz with an output power ?11.35 dBm. At 1 MHz frequency offset from the carrier at 8.22 GHz the phase noise is ?120.82 dBc/Hz, the figure of merit of the proposed oscillator is ?192.76 dBc/Hz. The oscillator chip occupies an area of 2 × 1 mm2.
关键词： phase noise,3-path transformer,figure of merit,Q-factor,8.22 GHz GaN HEMT oscillator
更新于2025-09-23 15:23:52