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MicroRNA-9 inhibits retinal neovascularization in rats with diabetic retinopathy by targeting vascular endothelial growth factor A
摘要： Diabetic retinopathy (DR) is a leading cause of adult visual impairment and loss. This study aims to explore the effects of microRNA‐9 (miR‐9) on retinal neovascularization during DR by targeting the vascular endothelial growth factor A (VEGFA). DR rat models were successfully established. Retinal microvascular endothelial cells (RMECs) of DR rats were isolated and treated with miR‐9 mimic, miR‐9 inhibitor or small interfering RNA (siRNA)‐VEGFA. The expressions of miR‐9, VEGFA, and cluster of differentiation 31 (CD31) of the rats’ tissues and cells were examined. The targeting relationship between miR‐9 and VEGFA was testified. The tubule formation, the cell proliferation and the periodic distribution and apoptosis were evaluated after transfection. In the retinal tissues of DR rats, miR‐9 expression decreased while the expression of VEGFA and CD31 increased. Notably, miR‐9 targeted and inhibited VEGFA expression. In response to the treatment of miR‐9 mimic and siRNA‐VEGFA, a reduction was identified in CD31 expression, tubule formation, and proliferation of RMECs and cell ratio in the S phase, but an increase was observed in apoptosis rate of RMECs. The treatment of miR‐9 inhibitor reversed the manifestations. Our study demonstrated that miR‐9 could inhibit retinal neovascularization of DR and tubule formation, and promote apoptosis in RMECs by targeting VEGFA.
关键词： retinal microvascular endothelial cells,diabetic retinopathy,vascular endothelial growth factor A,microRNA‐9,retinal neovascularization
更新于2025-09-23 15:21:21
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[IEEE 2018 VII. Lighting Conference of the Visegrad Countries (Lumen V4) - Trebic, Czech Republic (2018.9.18-2018.9.20)] 2018 VII. Lighting Conference of the Visegrad Countries (Lumen V4) - Factors Having a Crutial Impact on Energy Efficiency of Floodlighitng
摘要： Floodlighting designs have only been analysed in terms of visual and aesthetic beauty up to now. Research in the field of floodlighting has also focused on other aspects of this type of lighting in recent years. The energy efficiency issue and the impact on light pollution are the most crucial aspects. These issues have not yet been properly explored in the literature. Significant factors which affect the issue of the engineering aspect of floodlighting have to be determined and studied carefully because of their high importance. The main aim of this paper is to present the key factors which have a crucial impact on energy efficiency and light pollution in the field of floodlighting. These factors are: the direction and location of the lighting equipment, luminous intensity distribution, light output ratio, the method of floodlighting and the spectral power distribution of a light source, as well as the spectral distribution of the reflectance from the illuminated surface. Each of these factors are precisely commented on. These are presented by means of a calculation, a measurement or a visualization example, which clearly allow the crux of the problem to be analysed in the easiest way. The research shows that the problem of improving floodlighting design in respect of energy efficiency and light pollution is a complex and exacting problem for a lighting designer. It definitely requires the creation of an individual and unified system of assessment. It ought to take into account all the crucial factors and be simple, understandable and easy to use. Development of such a system is underway at the Lighting Technology Division of Warsaw University of Technology. It will soon be finalized in the form of a doctoral dissertation by one of the authors of this paper.
关键词： energy efficiency,lighting technology,floodlighting utilization factor,light pollution,floodlighting
更新于2025-09-23 15:21:21
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[IEEE 2018 VII. Lighting Conference of the Visegrad Countries (Lumen V4) - Trebic, Czech Republic (2018.9.18-2018.9.20)] 2018 VII. Lighting Conference of the Visegrad Countries (Lumen V4) - Directions of Research and Standardization in the Field of Outdoor Lighting
摘要： This paper aims to highlight current trends in research and standardization in light and lighting with focus on the outdoor lighting. Activities of the International Commission on Illumination (CIE) are briefly presented and detailed in selected topics picked up from the list of research priorities. The highlighted topics comprise adaptive lighting, tailored lighting, new lighting metrics, maintenance factor and obtrusive light issues in particular. Outlook for standardization items, priorities and strategy is outlined in the paper.
关键词： obtrusive light,smart lighting,research,outdoor lighting,maintenance factor,standardization,tailored lighting,light and lighting,adaptive lighting
更新于2025-09-23 15:21:21
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[IEEE 2018 VII. Lighting Conference of the Visegrad Countries (Lumen V4) - Trebic, Czech Republic (2018.9.18-2018.9.20)] 2018 VII. Lighting Conference of the Visegrad Countries (Lumen V4) - Evaluation of Selected Parameters of Non-Directional Household Lamps
摘要： Currently, in place of traditional incandescent lamps, the user of home lighting has the option of using halogen lamps. The lamps, compact fluorescent commercial offer is very wide and diverse, both as to the types of lamps and their prices. Usually, when buying a lamp, the user is guided by the price and parameters given on the packaging. Unfortunately, all parameters on the product packaging only constitute the manufacturer's declaration and do not always correspond to actual parameters. The basic requirements for non-directional lamps for home use are contained in the regulations of the Commission of the European Community. However, only the initial parameters are usually verified. Due to the long duration of measurements, operational parameters are not controlled each time. The article presents the results of tests and analysis of lumen maintenance factor of selected non-directional lamps for home use after a defined period of operation. The quality of the tested lamps was assessed.
关键词： selected non-directional lamps for home use,lamp lumen maintenance factor,initial parameter of lamp
更新于2025-09-23 15:21:21
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[IEEE 2018 VII. Lighting Conference of the Visegrad Countries (Lumen V4) - Trebic, Czech Republic (2018.9.18-2018.9.20)] 2018 VII. Lighting Conference of the Visegrad Countries (Lumen V4) - Electrical Parameters of Dimmable Luminaire
摘要： Lighting systems are currently one of the main uses of electricity. The most popular option for reducing of electricity consumption is the use of dimming. Dimming is a type of regulation in which we can regulate luminous flux of a lamps and luminaires. This system of regulation is used in the road lighting industry, but also in households. Dimming allows adaptation of the lighting system according to specific requirements and various ambient conditions such as traffic density, daylight, etc. The regulation of the luminous flux depending on the dimming system can affect the electrical parameters of the luminaires such as the power factor. The article deals with the electrical parameters of luminaires with various lamps at different types of dimming.
关键词： LED,total harmonic distortion,Power factor
更新于2025-09-23 15:21:21
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EFFECT OF SIZE ON SINGLE AND DOUBLE OPTICAL MICROBOTTLE RESONATOR HUMIDITY SENSORS
摘要： An experimental study on the effect of whispering gallery mode (WGMs) on micro-bottle resonator (MBR) and its application on humidity sensing is presented. Different transmission mode spectra observed when the diameter of MBR (Db) change from 130μm to 190μm. The Q-factor for single and double MBRs ware observed > 104 for all cases. The size and number of MBRs effecting Q-factor value which are high Q-factor value for smallest size Db = 130μm for single MBR and Pair-4 (combination of two biggest MBRs Db = 190μm) for double MBRs. Application of single and double MBRs in humidity sensing received various sensing performance. With the highest sensitivity value, linearity >90% and P-value > 10-13 make MBR with diameter 130μm to be the best performance as humidity sensor for all cases. Both single and double MBRs are stable over 60 seconds. Overall, the size of the MBR has been shown to be more important than the quantity of MBRs for humidity sensing. Indeed, double MBRs actually perform worse than single MBRs as humidity sensors.
关键词： Q-factor,Sensitivity,Humidity sensor,Whispering gallery mode,Micro-bottle resonator
更新于2025-09-23 15:21:21
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[IEEE 2019 IEEE International Conference on Telecommunications and Photonics (ICTP) - Dhaka, Bangladesh (2019.12.28-2019.12.30)] 2019 IEEE International Conference on Telecommunications and Photonics (ICTP) - Sensitivity Enhanced Surface Plasmon Resonance (SPR) Sensors with MoS <sub/>2</sub> /Graphene Hybrid Overlayer
摘要： A performance enhanced surface plasmon resonance sensor has been designed with a molybdenum disulfide (MoS2)/graphene hybrid overlayer. Atomically thin transition metal dichalcogenide (TMDC) nanomaterials like MoS2 have exhibited better optical and electronic properties in the two-dimensional (2D) scale. The MoS2/graphene hybrid overlayer protects the metal layer of the SPR sensor from undesired oxidation and retains higher sensitivity. As they have large surface to volume ratio and adjustable biocompatibility, the sensor performance increases several times than only graphene based configuration. The proposed SPR sensor includes a titanium (Ti) layer which enhances the adherence level between silver and prism glass. Sensitivity factor (SF), sensor merit (SM), full-width at half-maximum (FWHM) and combined sensitivity factor (CSF) have been used to measure the performance of the proposed sensor. The proposed sensor has the SF of 71.260/RIU and CSF of 372.72 RIU-1, which are much higher than the existing sensor configuration without MoS2 overlayer.
关键词： combined sensitivity factor,SPR sensor,MoS2 / graphene hybrid overlayer,sensitivity factor
更新于2025-09-23 15:21:01
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High-Speed Neuromorphic Reservoir Computing Based on a Semiconductor Nanolaser with Optical Feedback Under Electrical Modulation
摘要： A high-speed neuromorphic reservoir computing system based on a semiconductor nanolaser with optical feedback (SNL-based RC) under electrical modulation is proposed for the first time and demonstrated numerically. A Santa-Fe chaotic time series prediction task is employed to quantify the prediction performance of the SNL-based RC system. The effects of the Purcell cavity-enhanced spontaneous emission factor F and the spontaneous emission coupling factor β on the proposed RC system are analyzed extensively. It is found that, in general, increased F and β extend the range of good prediction performance of the SNL-based RC system. Moreover, the influences of bias current and feedback phase are also considered. Due to the ultra-short photon lifetime in SNL, the information processing rate of the SNL-based RC system reaches 10Gpbs. The proposed high-speed SNL-based RC system in this paper provides theoretical guidelines for the design of RC-based integrated neuromorphic photonic systems.
关键词： spontaneous emission coupling factor,Purcell factor,reservoir computing,Semiconductor nanolaser,delay systems
更新于2025-09-23 15:21:01
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Non-Lorentzian Local Density of States in Coupled Photonic Crystal Cavities Probed by Near- and Far-Field Emission
摘要： Recent theories proposed a deep revision of the well-known expression for the Purcell factor, with counterintuitive effects, such as complex modal volumes and non-Lorentzian local density of states. We experimentally demonstrate these predictions in tailored coupled cavities on photonic crystal slabs with relatively low optical losses. Near-field hyperspectral imaging of quantum dot photoluminescence is proved to be a direct tool for measuring the line shape of the local density of states. The experimental results clearly evidence non-Lorentzian character, in perfect agreement with numerical and theoretical predictions. Spatial maps with deep subwavelength resolution of the real and imaginary parts of the complex mode volumes are presented. The generality of these results is confirmed by an additional set of far-field and time-resolved experiments in cavities with larger modal volume and higher quality factors.
关键词： non-Lorentzian local density of states,Purcell factor,quantum dot photoluminescence,photonic crystal cavities,near-field hyperspectral imaging
更新于2025-09-23 15:21:01
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[IEEE 2020 IEEE Texas Power and Energy Conference (TPEC) - College Station, TX, USA (2020.2.6-2020.2.7)] 2020 IEEE Texas Power and Energy Conference (TPEC) - A Simplified DC Capacitor Active Voltage-Balance Algorithm with Common-Mode Voltage Reduction using Active-Zero SVPWM for Three-Level Photovoltaic Grid-Tie Inverter Application
摘要： This paper introduces a digitally controlled single-phase rectifier with power factor correction (PFC) based on a modified three-level boost converter topology. In comparison with the conventional boost-based systems, the new PFC rectifier has about three times smaller inductor and significantly lower switching losses. The improvements are achieved by replacing the output capacitor of the boost converter with a nonsymmetric active capacitive divider, with a 3:1 division ratio, and by utilizing the downstream converter stage for the capacitive divider’s center-tap voltage regulation. The nonsymmetric voltage divider and applied switching sequence effectively provide four-level converter behavior using the same number of components as three-level converters. As a result, a 66% reduction of the inductor compared to the conventional boost-based PFC and a 33% compared to the standard three-level solutions operating at the same effective switching frequencies are also achieved. Experimental results obtained with a 400 W, 200 kHz, universal input voltage (85 Vrms –265 Vrms) PFC prototype demonstrate three times smaller inductor current ripple than that of the conventional boost converter allowing for the same inductor reduction. Efficiency improvements of up to a 6% are also demonstrated.
关键词： boost converter,power factor correction (PFC),multilevel converters,AC-DC converters
更新于2025-09-23 15:21:01