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BODIPY derivatives bearing borneol moieties: Enhancing cell membrane permeability for living cell imaging
摘要： Three novel boron-dipyrromethene (BODIPY) dyes bearing borneol moieties have been designed, synthesized and characterized. The single-crystal structure of the compound 3 was also elucidated for the first time. Their photophysical properties and confocal fluorescence images were investigated by the optical spectroscopy and Confocal fluorescence microscopy. The results indicate that the compounds 2-3 take on high fluorescence quantum yield and cell membrane permeability, which can be utilized as fluorescent visualizers for cell and lysosome fluorescence imaging.
关键词： photophysical properties,borneol,cell imaging,BODIPY,membrane permeability
更新于2025-09-23 15:23:52
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A CSRR-Based Sensor for Full Characterization of Magneto-Dielectric Materials
摘要： In this paper, a novel complementary split-ring resonator (CSRR)-based sensor for full characterization of magneto-dielectric materials is proposed. In general, the operation of microwave resonance-based sensor hinges on the shift in the resonance frequency and the change in the quality factor of the loaded structure. However, both the electric permittivity and the magnetic permeability of the material under test (MUT) have similar effect on the response of the sensor that makes the simultaneous determination of the permittivity and permeability challenging. To remove this difficulty, the main idea behind this paper is to localize the highest intensity of the electric and magnetic fields in two separate zones. By the analysis of the measured resonance frequency and quality factor, the real and imaginary parts of the electric permittivity and the magnetic permeability of the MUT can be determined. Although the characterization of the permittivity and permeability of materials using split-ring resonator and CSRR-based sensors has been widely used, to the best of our knowledge, the full characterization of magneto-dielectric materials using a single sensor has not yet been reported in this paper. As a proof of concept, the sensor was fabricated and used to measure the permittivity and permeability of several materials. Strong agreement between the extracted values and the reference data was achieved.
关键词： sensor,Complementary split ring resonator (CSRR),material characterization,split ring resonator (SRR),magneto-dielectric materials,permittivity and permeability
更新于2025-09-23 15:23:52
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Spectroscopy of Oxygen-Sensitive Material for Measuring Contact Lens Oxygen Transmissibility
摘要： Purpose: Oxygen permeability or transmissibility is a crucial parameter for contact lenses to ensure that extended wear will not induce corneal hypoxia. This work tests a new method of using the oxidation of cysteamine, an oxygen-sensitive chemical, to quantify the oxygen transmissibility of current commercial contact lenses and contact lenses loaded with vitamin E. Methods: 3D printing was used to modify eye drop bottles and quartz cuvettes to create systems that allowed insertion of a contact lens in between the cysteamine solution and air. Both systems were exposed to atmospheric conditions where the only path of entry for oxygen was through the contact lens. The entering oxygen reacted with cysteamine, and the rate of cysteamine oxidation was measured using UV-vis spectrophotometry. The rate was then stoichiometrically related to oxygen transmissibility. Results: The eye drop method predicted transmissibility values within 9% of established, commercial values. The cuvette method predicted values within 10% of established values for silicone hydrogel lenses without any correction factor and within 11% for poly-hydroxyethyl-methacrylate lenses after correcting for oxygen entering the system. Incorporation of 20% (w/w) vitamin E into Acuvue? Oasys? lenses did not have a significant impact on the oxygen transmissibility. Conclusions: Both methods presented in this work can reliably measure oxygen transmissibility of contacts lenses or other materials. Further improvements in manufacturing could lead to improved accuracy and reliability, allowing wider use of this method for quantifying the oxygen transport in contact lenses.
关键词： oxidation,oxygen permeability,spectrophotometry,3D printing,contact lens
更新于2025-09-23 15:23:52
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[IEEE NAECON 2018 - IEEE National Aerospace and Electronics Conference - Dayton, OH, USA (2018.7.23-2018.7.26)] NAECON 2018 - IEEE National Aerospace and Electronics Conference - Impact of dielectric and magnetic losses on the negative index characteristics of a chiral material with first-order sideband dispersion
摘要： Electromagnetic propagation in chiral materials under first-order dispersion is examined for negative indices under non-conductive losses. Three loss scenarios are considered, viz., dielectric (complex permittivity) losses; magnetic (complex permeability) losses; and a combination of both types of losses to investigate the overall impact of the losses on the emergence of negative index bands.
关键词： complex permittivity and permeability,loss compensation,plane wave polarization,material dispersion,negative index bands,Negative refractive index
更新于2025-09-23 15:22:29
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[IEEE 2018 Conference on Precision Electromagnetic Measurements (CPEM 2018) - Paris (2018.7.8-2018.7.13)] 2018 Conference on Precision Electromagnetic Measurements (CPEM 2018) - Conceptual Consequences of the SI
摘要： The SI and its forerunners were largely developed in response to the confusion of multiple electromagnetic unit systems at the start of the 20th century. More than 100 years later, the success of the SI is evidenced by its almost universal acceptance. The adoption of the ampere as the fourth base unit has proved to be a beneficial way of simplifying electromagnetic units. However, an unintended consequence of adopting this system has been the development of several misconceptions regarding the physics of electromagnetic quantities. The anticipated educational activities associated with the upcoming SI redefinition offer an ideal opportunity to resolve this concern.
关键词： CGS,Permeability of Free Space,SI,Ampere,Magnetic Constant,Electrical Units
更新于2025-09-23 15:22:29
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Breathing and Coughing: The Extraordinarily High Degassing of Popocatépetl Volcano Investigated With an SO2 Camera
摘要： How do lava domes release volcanic gases? Studying this problem is crucial to understand, and potentially anticipate, the generation of the sudden and dangerous explosive eruptions that frequently accompany dome extrusions. Since its awakening in 1994, Popocatépetl volcano has produced more than 50 lava domes and has been consistently among the strongest permanent emitters of volcanic gases. In this work, we have characterized the passive and explosive degassing between 2013 and 2016 at a high time resolution using an SO2 camera, to achieve a better understanding of the conduit processes. Our 4-year average SO2 ?ux is 45 kg/s, in line with the long-term average of the whole current eruptive period. We show that Popocatépetl volcano is essentially an open system and that passive degassing, i.e., degassing with no associated emission of lava or ash, dominates >95% of the time. This passive degassing is continuous and sustained, whether the crater contains a lava dome or not. It shows most of the time a strong periodic component, with a pseudo-period of ～5 min, and amplitudes of 30 to 60% of the average value. We could distinguish two types of explosions based on their SO2 ?ux patterns. The ?rst type (E1) occurs in the middle of the normal passive degassing and is followed by a rapid return of the SO2 ?ux down to its pre-explosive level. The second type (E2), which corresponds to the strongest events, is anticipated by a rapid decrease of the SO2 ?ux to abnormally low values and is followed by a return to its normal values. The E2 explosions are probably caused by the accumulation of gas below a rapidly compacting permeable dome. We suggest that transient episodes of gravitational compaction of the usually permeable dome and the upper conduit is the only mechanism that is fast enough to explain the sharp decrease of the SO2 ?ux that anticipates the E2 explosions. Our model is potentially applicable to a large number of andesitic volcanoes that undergo passive degassing interspersed with short-lived explosions.
关键词： volcanic degassing,Popocatépetl,lava dome,permeability,explosions,SO2 camera
更新于2025-09-23 15:22:29
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Photooxidation of unilamellar vesicles by a lipophilic pterin: Deciphering biomembrane photodamage
摘要： Pterins are natural products that can photosensitize the oxidation of DNA, proteins and phospholipids. Recently, a new series of decyl-chain (i.e., lipophilic) pterins were synthesized and their photophysical properties investigated. These decyl-pterins led to efficient intercalation in large unilamellar vesicles and produce, under UVA irradiation, singlet molecular oxygen, a highly oxidative species that react with polyunsaturated fatty acids (PUFAs) to form hydroperoxides. Here, we demonstrate that the association of 4-(decyloxy)pteridin-2-amine (O-decyl-Ptr) to lipid membranes is key to its ability to trigger phospholipid oxidation in unilamellar vesicles of phosphatidylcholine rich in PUFAs used as model biomembranes. Our results show that O-decyl-Ptr is at least one order of magnitude more efficient photosensitizer of lipids than pterin (Ptr), the unsubstituted derivative of the pterin family, which is more hydrophilic and freely passes across lipid membranes. Lipid peroxidation photosensitized by O-decyl-Ptr was detected by the formation of conjugated dienes and oxidized lipids, such as hydroxy and hydroperoxides derivatives. These primary products undergo a rapid conversion into short-chain secondary products by cleavage of the fatty acid chains some of which are due to subsequent photosensitized reactions. As a consequence, a fast increase in membrane permeability is observed. Therefore, lipid oxidation induced by O-decyl-Ptr could promote cell photodamage due to the biomembrane integrity loss which, in turn, may trigger cell death.
关键词： alkyl-pterins,membrane permeability,lipid peroxidation,photosensitization
更新于2025-09-23 15:21:21
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Increasing Membrane Permeability by Increasing the Polymer Crystallinity: The Unique Case of Polythiophenes
摘要： It is generally accepted in membrane technology that crystalline zones in polymeric membranes do not contribute to transport of liquids or gases. In the current study, poly(3-alkylthiophene)s (P3ATs), i.e., homopolymers and random copolymers, were synthesized to study the influence of the supramolecular organization on membrane gas separations. The monomers were polymerized via KCTCP, and GPC analysis shows that the polymers have a narrow dispersity. DSC analysis of the polymers reveals that the homopolymers, in contrast to the copolymers, crystallized, confirming their higher degree of supramolecular organization. This was supported by UV?vis absorption spectra of the polymer films, where a red-shift and a characteristic shoulder absorption peak around 600 nm were observed for the homopolymers, while absent for the copolymers. More surprisingly, the homopolymers were found to be 2 orders of magnitude more permeable to CO2 than the copolymers and also more selective.
关键词： selectivity,gas separations,permeability,membrane technology,supramolecular organization,poly(3-alkylthiophene)s,crystallinity
更新于2025-09-23 15:21:21
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ANALYSIS OF THE NICOLSON-ROSS-WEIR METHOD FOR CHARACTERIZING THE ELECTROMAGNETIC PROPERTIES OF ENGINEERED MATERIALS
摘要： A method for predicting the behavior of the permittivity and permeability of an engineered material by examining the measured S-parameters of a material sample is devised, assuming that the sample is lossless and symmetric. The S-parameter conditions under which the material parameters extracted using the Nicolson-Ross-Weir method may be associated with a lossless homogeneous material are described. Also, the relationship between the signs of the real and imaginary parts of the permittivity and permeability are determined, both when the extracted material parameters are real and when they are complex. In particular, the conditions under which metamaterials exhibit double-negative properties may be predicted from the S-parameters of a metamaterial sample. The relationships between material characteristics and the S-parameters should prove useful when synthesizing materials to have certain desired properties. Examples, both from experiment and simulation, demonstrate that the relationships may be used to understand the behavior of several di?erent categories of engineered materials, even when the materials have appreciable loss.
关键词： S-parameters,engineered materials,permeability,permittivity,metamaterials,Nicolson-Ross-Weir method
更新于2025-09-23 15:21:21
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Augmented tumor accumulation and photothermal ablation using gold nanoparticles with a particular cellular entry orientation
摘要： Gold nanoparticles with various functionalities have served as potential tools in nanotechnology for tumor ablation. In this work, we seek to design and develop gold nanoparticle with poly(ethylene glycol)-containing dopamine (hereafter termed as AuND), and to synthesize the AuND with one-sided Tat peptide expression (OT@AuND). We demonstrate the tumor cell-targeting ability on the basis of anti-nonspecific cell binding of OT@AuND and determine how the chemically modified gold nanoparticle–based product affects photothermal tumor therapy in vitro and in vivo. The OT@AuND with a particular cellular entry orientation–induced delayed endocytosis, which is advantageous for enhanced permeability and retention effect-based tumor accumulation. This is because the slower cellular interaction of OT@AuND allows it to have the time to be transported to and bind to the tumor site. In tumor cell lines, OT@AuND showed a lower cellular uptake than gold nanoparticles with full-sided Tat peptide expression (FT@AuND) in the early period (after its in vitro and in vivo administration), but the cellular internalization rate of OT@AuND caught up with that of FT@AuND in the late period. Importantly, the delayed cellular internalization feature of OT@AuND resulted in efficient tumor accumulation in tumor-bearing mice, because the time interval provided OT@AuND more chances not to bind to any cells, but to enter tumor cells, leading to selective photothermal tumor ablation. These data suggest that gold nanoparticles with a particular cellular entry orientation can be further explored as a potential photothermal therapeutic agent and as a strategy to treat tumors.
关键词： photothermal tumor ablation,cellular entry orientation,Gold nanoparticles,one-sided Tat peptide,enhanced permeability and retention
更新于2025-09-23 15:21:21