- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
A Case of Advanced Malignant Pleural Mesothelioma Treatment with Chemotherapy and Photodynamic Therapy
摘要： Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant, and generally fatal disease. A 68-year-old male who was diagnosed with MPM at another hospital came to our hospital with dyspnea. We advised him to take combination chemotherapy but he refused to take the treatment. That was because he had already received chemotherapy with supportive care at another hospital but his condition worsened. Thus, we recommended photodynamic therapy (PDT) to deal with the dyspnea and MPM. After PDT, the dyspnea improved and the patient then decided to take the combination chemotherapy. Our patient received chemotherapy using pemetrexed/cisplatin. Afterwards, he received a single PDT treatment and then later took chemotherapy using gemcitabine/cisplatin. The patient showed a survival time of 27 months, which is longer than median survival time in advanced MPM patients. Further research and clinical trials are needed to demonstrate any synergistic effect between the combination chemotherapy and PDT.
关键词： Photodynamic Therapy,Chemotherapy,Pleura,Mesothelioma, Malignant
更新于2025-09-19 17:15:36
-
CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators
摘要： The use of X-rays instead of UV/Vis light to trigger photodynamic therapy, named X-ray inducible photodynamic therapy, holds tremendous promise due to a high penetration capacity in tissues and is worthy of in-depth study. In this study, a novel multifunctional nanoagent based on Merocyanine 540-coupled Gd2(WO4)3:Tb nanoscintillators and the vitalization of its abilities for dual-modal computed tomography and the magnetic-resonance-imaging-guided synergistic radio-/X-ray inducible photodynamic therapy of tumors is reported. Synergistic therapies show a higher tumor growth inhibition efficiency at a lower X-ray dose than radiotherapy alone. Through this proof-of-concept work, a way to tactfully understand and utilize nanoscintillators for cancer theranostics is shown.
关键词： nanoscintillators,radiotherapy,magnetic resonance imaging,computed tomography,X-ray inducible photodynamic therapy
更新于2025-09-19 17:15:36
-
Photodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity
摘要： Photodynamic therapy (PDT) is an established noninvasive tumor treatment. The hydrophobic natural occurring pigment hypericin shows a lot of attractive properties for the application in PDT. Hence, the administration to biological systems or patients requires the formulation in drug carriers enabling sufficient bioavailability. Therefore, free hypericin was encapsulated by the thin film hydration method or a hypericin-hydroxypropyl-b-cyclodextrin inclusion complex (Hyp-HPbCD) was incorporated by dehydration-rehydration vesicle method in either conventional or ultra-stable tetraether lipid (TEL) liposomes. The hydrodynamic diameter of the prepared nanoformulations ranged between 127 and 212 nm. These results were confirmed by atomic force microscopy. All liposomes showed a good stability under physiological conditions. TEL liposomes which tend to build more rigid bilayers, generate higher encapsulation efficiencies than their conventional counterparts. Furthermore, the suitability for intravenous application was confirmed by hemocompatibility studies resulting in a hemolytic potential less than 20% and a coagulation time less than 50 sec. The uptake of liposomal hypericin into human ovarian carcinoma cells (SK-OV-3) was confirmed using confocal microscopy and further characterized by pathway studies. It was demonstrated that the lipid composition and intraliposomal hypericin localization influenced the anti-vascular effect in the chorioallantoic membrane (CAM). While hypericin TEL liposomes exhibit substantial destruction of the microvasculature drug-in-cyclodextrin TEL liposomes showed no effect. Nevertheless, both formulations yielded severe photocytotoxicity in SK-OV-3 cells in a therapeutic dosage range. Conclusively, hypericin TEL liposomes would be perfectly suited for anti-vascular targeting while Hyp-HPbCD TEL liposomes could deliver the photosensitizer to the tumor site in a more protected manner.
关键词： Antitumor,hypericin,antiangiogenic,photodynamic therapy,liposomes
更新于2025-09-19 17:15:36
-
Heavy-atom-free charge transfer photosensitizers: Tuning the efficiency of BODIPY in singlet oxygen generation via intramolecular electron donor-acceptor interaction
摘要： To test the tunability of charge transfer (CT)-based BODIPY photosensitizers in generating singlet oxygen (1D g), twelve meso-phenyl-BODIPY (donor-acceptor) type compounds have been synthesized and fully characterized, in which the phenyl moiety is modified with respective 0, 1, 2 and 3 methoxy groups to increase its electron-donating ability. The UV-Vis absorption spectra, fluorescence emission spectra, fluorescence quantum yield, fluorescence lifetime, excited triplet state formation, and singlet oxygen formation properties are measured. DFT quantum chemical computation is also carried out to explain the experiments. The occurrence of intra-molecular CT is confirmed by UV-Vis absorption, fluorescence properties and quantum chemical computation. The triplet excited state formation is evidenced by laser flash photolysis technique. The quantitative photosensitized singlet oxygen formation is demonstrated by DPBF (diphenylisobenzofuran) chemical trapping method. This type of BODIPY CT photosensitizers show good tunability in generating singlet oxygen (1D g). When the number of methoxy group on the donor is increased (so that CT is enhanced), the efficiency of singlet oxygen generation becomes higher from 0.070 to 0.30. When solvent polarity is increased (CT is also enhanced), the efficiency of singlet oxygen generation is also increased significantly. The increase in singlet oxygen generation is accompanied by the decrease in fluorescence quantum yield and fluorescence lifetime values. These facts show that a higher CT efficiency in a simple phenyl-BODIPY donor-acceptor conjugate can lead to significant higher quantum yield of singlet oxygen generation. These results are useful in designing novel CT-based heavy-atom-free photosensitizers for photodynamic therapy of tumor.
关键词： Charge transfer photosensitizer,singlet oxygen,BODIPY,photodynamic therapy
更新于2025-09-19 17:15:36
-
Novel Hexadeca-Substituted Metal Free and Zinc(II) Phthalocyanines; Design, Synthesis and Photophysicochemical Properties
摘要： The syntheses of a novel 1,4,8,11,15,18,22,25-octahexyloxy-2,3,9,10,16,17,23,24-octa-(4-trifluoromethoxyphenyl) phthalocyanine (3a) and its zinc(II) phthalocyanine derivative (3b) have been described and characterized by elemental analysis, 1H NMR, 13C NMR, 19F NMR, mass, UV-Vis and FT-IR. The newly prepared metal-free phthalocyanine and its zinc(II) counterpart are soluble in most organic solvents. The photophysical and photochemical properties such as aggregation, fluorescence, singlet oxygen generation and photodegradation under light irradiation of these phthalocyanines have been investigated in DMF. The hexadeca-substituted phthalocyanines (3a and 3b) showed longer absorption and emission wavelength values when compared to that of reported phthalocyanine derivatives due to substitution of the all possible positions in the phthalocyanine framework. The zinc(II) phthalocyanine derivative does not only have a good singlet oxygen generation but also has other photophysicochemical properties that enables this phthalocyanine to be useful as a photosensitizer for cancer treatment using photodynamic therapy.
关键词： phthalocyanine,Suzuki-coupling,photodynamic therapy,photochemical,photophysical
更新于2025-09-19 17:15:36
-
Methylene blue loaded Cu-tryptone complex nanoparticles: a new glutathione-reduced enhanced photodynamic therapy nanoplatform
摘要： The concentration of intracellular reactive oxygen species directly determines the effect of photodynamic therapy. Reducing intracellular glutathione (GSH) content can increase ROS level. Therefore, it is extremely important to construct a nano-platform that can promote photodynamic therapy by consuming GSH. In this study, we synthesized Cu-tryptone complex nanoparticles (Cu-Try NPs) by a simple green method and demonstrated their ability to consume GSH to increase intracellular ROS for the first time. Photosensitizer methylene blue was loaded onto Cu-Try NPs (Cu-Try/MB NPs) for enhanced photodynamic therapy. Studies in vitro and in vivo illustrated that enhanced photodynamic therapy based on Cu-Try/MB NPs can kill cancer cells effectively.
关键词： glutathione,Cu-tryptone complex nanoparticles,photodynamic therapy
更新于2025-09-19 17:15:36
-
Modulation of Intracellular Oxygen Pressure by Dual-Drug Nanoparticles to Enhance Photodynamic Therapy
摘要： Oxygen plays an essential role in the photodynamic therapy (PDT) of cancer. However, hypoxia inside tumors severely attenuates the therapeutic effect of PDT. To address this issue, a novel strategy is reported for cutting off the oxygen consumption pathway by using sub-50 nm dual-drug nanoparticles (NPs) to attenuate the hypoxia-induced resistance to PDT and to enhance PDT efficiency. Specifically, dual-drug NPs that encapsulate photosensitizer (PS) verteporfin (VER) and oxygen-regulator atovaquone (ATO) with sub-50 nm diameters can penetrate deep into the interior regions of tumors and effectively deliver dual-drug into tumor tissues. Then, ATO released from NPs efficiently reduce in advance cellular oxygen consumption by inhibition of mitochondria respiratory chain and further heighten VER to generate greater amounts of 1O2 in hypoxic tumor. As a result, accompanied with the upregulated oxygen content in tumor cells and laser irradiation, the dual-drug NPs exhibit powerful and overall antitumor PDT effects both in vitro and in vivo, and even tumor elimination. This study presents a potential appealing clinical strategy in photodynamic eradication of tumors.
关键词： atovaquone,verteporfin,hypoxia,oxygen consumption rate,photodynamic therapy
更新于2025-09-19 17:15:36
-
CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators
摘要： The use of X-rays instead of UV/Vis light to trigger photodynamic therapy, named X-ray inducible photodynamic therapy, holds tremendous promise due to a high penetration capacity in tissues and is worthy of in-depth study. In this study, a novel multifunctional nanoagent based on Merocyanine 540-coupled Gd2(WO4)3:Tb nanoscintillators and the vitalization of its abilities for dual-modal computed tomography and the magnetic-resonance-imaging-guided synergistic radio-/X-ray inducible photodynamic therapy of tumors is reported. Synergistic therapies show a higher tumor growth inhibition efficiency at a lower X-ray dose than radiotherapy alone. Through this proof-of-concept work, a way to tactfully understand and utilize nanoscintillators for cancer theranostics is shown.
关键词： magnetic resonance imaging,nanoscintillators,computed tomography,X-ray inducible photodynamic therapy,radiotherapy
更新于2025-09-19 17:15:36
-
Aggregation-induced emission (AIE)-active molecules bearing singlet oxygen generation activities: the tunable singlet–triplet energy gap matters
摘要： Herein, a series of photosensitizers were constructed of a, b and c-isomers of terpyridine and the corresponding N-methylation derivatives. Benefiting from the tunable singlet–triplet energy gap and aggregation-induced emission characteristics, two-photon active photosensitizers L2b and L2c showed relatively strong intersystem crossing facilitating 1O2 generation and cell apoptosis with near-infrared excitation.
关键词： Aggregation-induced emission,singlet oxygen generation,photodynamic therapy,photosensitizers,two-photon excitation
更新于2025-09-19 17:15:36
-
Present and future perspectives of photodynamic therapy for cutaneous squamous cell carcinoma
摘要： Cutaneous squamous cell carcinoma (SCC) is the second most common skin cancer. Surgery remains the main stay of treatment, but some patients are not eligible for surgery and, more importantly, lesions at critical sites need nonsurgical approaches for tissue preservation. In this context, photodynamic therapy (PDT) has been extensively studied as noninvasive or minimally invasive treatment, and studies have shown promising results in terms of safety, efficacy, and cosmetic outcome. Also, studies have proposed different mechanism for its efficacy. However, human studies demonstrating its efficacy are limited in terms of sample size and tumor depth of invasion. Good results are mainly seen in case reports of microinvasive SCC, which is defined as SCC limited to papillary dermis. This inadequacy is due to inadequate penetration of topically applied photosensitizers through keratinized tumor surfaces. To overcome these hurdles, pretreatment with lasers or microneedles and encapsulation of photosensitizers into nanoparticles have been tried. Hence, the present article will discuss studies that have demonstrated the efficacy and safety of PDT for cutaneous SCC, studies that have postulated the mechanism of action of PDT, agents that have been used as PDT enhancers, and finally, the recent use of adjuvant therapy in combination with PDT.
关键词： mechanism of action,surgery,photodynamic therapy,nanomedicine,cutaneous squamous cell carcinoma
更新于2025-09-19 17:15:36