- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Photodegradable MEH-PPV in a natural rubber matrix: Toward a biocompatible colorimetric film for real-time light dosimetry
摘要： This paper reports an interesting strategy of incorporating a photodegradable polymeric luminophore, the poly [2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] - OC10C6-PPV (MEH-PPV), in an inert natural rubber (Hevea brasiliensisis) - C5H8 (NR) matrix for monitoring and recording the radiation dose administered to patients under phototherapy, particularly in the treatment for jaundice newborns. A time-trend spectro?uorimetric study has been carried out to characterize the luminescent changes of the MEH-PPV/NR luminophore system upon photodegradation by realistic conditions of phototherapy treatment, and the dependence between color and dose was used to determine the dose-response relationships of this color ?lm dosimeter. Cytotoxicity tests (CHO-K1 cell line) have also been conducted on extracts of the OC10C6-PPV/C5H8 before and after photolysis. The experimental results reported here highlight the potential application of photodegradable polymer/natural rubber as a biocompatible skin-mountable patch to monitor light exposure to improve patient care in phototherapy, photodynamic, lasers and radiation therapies.
关键词： Medical-devices,Dosimeter,Printable device,Photooxidation,Organic device,Semiconducting polymer,Radiation oncology
更新于2025-11-14 15:18:02
-
Semiconducting Polymer Dots as Broadband Saturable Absorbers for Q-switched Fiber Lasers
摘要： Semiconducting polymer dots (Pdots) have attracted much attention due to their outstanding optical properties. However, Pdots potential in laser technology is rare. Here, we first report the benzobisthiadiazole (BBT)-based Pdot as a single broadband nonlinear saturable absorber (SA) for passively Q-switched fiber lasers at 1, 1.5, and 2 μm. The Pdots-SA possesses a strong saturable absorption, broadband nonlinear optical response, and large modulation depth. Once the Pdots-SA is integrated into the ytterbium-, erbium-, and thulium-doped fiber laser cavities, stable Q-switched operations are observed at the central wavelengths of 1036, 1561, and 1951 nm. Our results verify that the Pdots are promising nonlinear media for Q-switched pulses generation, and highlight the potential of Pdots for relevant nonlinear optical applications.
关键词： Saturable absorber,Semiconducting polymer dots,Q-switched fiber lasers,Broadband nonlinear optical response
更新于2025-09-23 15:19:57
-
Near-Infrared Afterglow Semiconducting Nano-polycomplexes for Multiplex Differentiation of Cancer Exosomes
摘要： As nanoscaled extracellular vehicles inheriting genetic and protein information from source cells, detection of exosomes is promising for early diagnosis of cancer. However, optical sensors with high specificity and low medium background remain challenging for detection of exosomes. We herein develop the first luminescent nanosensor that bypasses real-time light excitation for multiplex differentiation of cancer exosomes. Such an afterglow luminescent nanosensor is composed of a near-infrared (NIR) semiconducting polyelectrolyte (ASPN) electrostatically complexed with a quencher-tagged aptamer. The afterglow signal of the nanocomplex (ASPNC) is initially quenched due to the efficient electron transfer between ASPN and the quencher. However, the presence of aptamer-targeted exosome increases ASPN/quencher distance, turning on afterglow signal. Because the afterglow detection is conducted after cessation of light excitation, the sample background signal is greatly minimized, affording the limit of detection that is nearly two orders of magnitude lower than fluorescence detection in cell culture medium. More importantly, ASPNC can be easily tailored to detect different exosomal proteins simply by changing the sequence of aptamer. Such a structural versatility of ASPNC enables orthogonal analysis of multiple exosome samples, potentially permitting accurate identification of the cellular origin of exosomes for cancer diagnosis.
关键词： optical imaging,semiconducting polymer,nanomaterials,biosensor,exosome
更新于2025-09-19 17:15:36
-
Controlled polymer crystal/two-dimensional material heterostructures for high-performance photoelectronic applications
摘要： Controlled polymer crystal/two-dimensional material heterostructures for high-performance photoelectronic applications
关键词： epitaxy,epitaxial interaction,semiconducting polymer,graphene,crystal interaction,transition-metal dichalcogenide,ferroelectric polymer,two-dimensional materials
更新于2025-09-19 17:13:59
-
Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence
摘要： Theranostic systems combining fluorescence imaging in the second near infrared window (NIR-II, 1000-1700 nm) and photothermal therapy (PTT) under safe laser fluence have great potential in preclinical research and clinical practice, but the development of such systems with sufficient effective NIR-II brightness and excellent photothermal properties is still challenging. Here we report a theranostic system based on semiconducting polymer nanoparticles (L1057 NPs) for NIR-II fluorescence imaging and PTT under a 980 nm laser irradiation, with low (25 mW/cm2) and high (720 mW/cm2) laser fluence, respectively. Taking into consideration multiple parameters including extinction coefficient, quantum yield and portion of emission in the NIR-II region, L1057 NPs have much higher effective NIR-II brightness than most reported organic NIR-II fluorophores. The high brightness, together with good stability and excellent biocompatibility, allows for real-time visualization of whole-body and brain vessels and detection of cerebral ischemic stroke and tumors with high clarity. The excellent photothermal properties and high maximal permissible exposure (MPE) limit at 980 nm allow L1057 NPs for PTT of tumors under safe laser fluence. This study demonstrates that L1057 NPs behave as an excellent theranostic system for NIR-II imaging and PTT under safe laser fluence and have great potential for a wide range of biomedical applications.
关键词： nanoparticle,effective NIR-II brightness,semiconducting polymer,photothermal therapy,fluorescence imaging
更新于2025-09-19 17:13:59
-
Influence of structural parameters on organic semiconducting polymer lasers with an external holographic grating as feedback layer
摘要： We report on the fabrication and characterization of an organic distributed feedback laser excited from a semiconducting polymer gain layer, poly(2-methoxy-5-(20-ethyl-hexyloxy)-p-phenyl-envinylene) (MEH-PPV). A holographic polymer dispersed liquid crystal grating is fabricated on top of the homogeneous MEH-PPV layer as an external cavity. We established a model to calculate the con?nement factor Γ. With the change of laser structural parameters (the refractive index of the grating layer, the ?lm thickness of the MEH-PPV layer, etc.), the con?nement factor Γ changes accordingly. It was found that a single longitudinal lasing mode could be observed only when the con?nement factor Γ was in a speci?c range. Choosing a reasonable thickness of gain ?lm and prepolymer with higher refractive index can obtain a lower threshold emission laser.
关键词： organic distributed feedback laser,lasing mode,semiconducting polymer,holographic polymer dispersed liquid crystal grating,con?nement factor
更新于2025-09-12 10:27:22
-
Organic semiconducting polymer amphiphile for near-infrared-II light-triggered phototheranostics
摘要： Development of near-infrared-II (NIR-II) light responsive nano-agents with high photothermal stability, high photothermal conversion efficiency (PCE), and excellent biocompatibility for photoacoustic (PA) imaging-guided photothermal therapy (PTT) is of tremendous significance. In spite of the superiority of organic semiconducting polymer nanoparticles (OSPNs) in PA imaging-guided PTT, the limited absorption in the first NIR (NIR-I) window and metastable nanostructure of OSPNs resulting from commonly used preparation methods based on nanoprecipitation or reprecipitation compromise their in vivo phototheranostic performance. Herein we design and synthesize a novel NIR-II absorbing organic semiconducting polymer amphiphile (OSPA) to enhance the structural stability of OSPNs. With prominent optical properties, low toxicity, and a suitable size, OSPA not only efficiently labels and kills cancer cells under NIR-II irradiation but also accumulates at the tumor of living mice upon intravenous injection, allowing efficient NIR-II light-triggered phototheranostics toward tumor. The developed OSPA has promising potential for fabricating multifunctional nanoplatforms to enable multimodal theranostics.
关键词： second near-infrared window,photoacoustic imaging,semiconducting polymer,amphiphile,photothermal therapy
更新于2025-09-12 10:27:22
-
Solution-Processed Phototransistors Combining Organic Absorber and Charge Transporting Oxide for Visible to Infrared Light Detection
摘要： This report demonstrates high-performance infrared phototransistors that uses a broadband absorbing organic bulk heterojunction (BHJ) layer responsive from the visible to the shortwave infrared, from 500 nm to 1400 nm. The device structure is based on a bilayer transistor channel that decouples charge photogeneration and transport, enabling independent optimization of each process. The organic BHJ layer is improved by incorporating camphor, a highly polarizable additive that increases carrier lifetime. An indium zinc oxide transport layer with high electron mobility is employed for rapid charge transport. As a result, the phototransistors achieve a dynamic range of 127 dB and reach a specific detectivity of 5×1012 Jones under low power illumination of 20 nW/cm2, outperforming commercial germanium photodiodes in the spectral range below 1300 nm. The photodetector metrics are measured with respect to the applied voltage, incident light power, and temporal bandwidth, demonstrating operation at the video-frame rate of 50 Hz. In particular, the frequency and light dependence of the phototransistor characteristics are analyzed to understand the change in photoconductive gain under different working conditions.
关键词： shortwave infrared,phototransistor,indium zinc oxide,bulk heterojunction,carrier lifetime,semiconducting polymer,camphor
更新于2025-09-11 14:15:04
-
Ratiometric Fluorescent Detection of Intracellular Singlet Oxygen by Semiconducting Polymer Dots
摘要： Singlet oxygen (1O2) plays important roles in many biological processes. However, it is very difficult to detect 1O2 in the intracellular environment owing to its relatively low concentration and short lifetime. Here, we developed a ratiometric probe based on semiconducting polymer dots (Pdots) that can sensitively detect 1O2 in live cells. An organic dye, singlet oxygen sensor green (SOSG), was doped in polyfluorene Pdots, and excitation energy was efficiently transferred from the polymer to the SOSG dye. Accordingly, the Pdots showed constant blue fluorescence as a reference, and increased green fluorescence upon singlet oxygen generation. The ratiometric response of Pdots was examined in the intracellular environment by in-situ 1O2 generation with a photosensitizer and light irradiation. Both spectroscopic measurements and confocal imaging were performed to monitor intracellular 1O2 generation during photodynamic therapy using the Pdot probe. Our results indicate that the SOSG-doped Pdots are promising for intracellular 1O2 detection.
关键词： Semiconducting polymer dots,Intracellular detection,Singlet oxygen,Photodynamic therapy,Ratiometric probe
更新于2025-09-11 14:15:04
-
pH/NIR-responsive semiconducting polymer nanoparticles for highly effective photoacoustic image guided chemo-photothermal synergistic therapy
摘要： Multifunctional drug delivery nanoplatform (PDPP3T@PSNiAA NPs) based on NIR absorbing semiconducting polymer nanoparticles for pH/NIR light-controllably regulated drug release has been successfully prepared. In this strategy, pH/thermal-sensitive multifunctional polymer polystyrene-b-poly(N-isopropylacrylamide-co-acrylic acid) (PSNiAA) was meticulously designed and synthesized using the reversible addition fragmentation chain transfer (RAFT) polymerization method. Furthermore, PSNiAA was first used to functionalize diketopyrrolopyrrole-based semiconducting polymer (PDPP3T) to combine photothermal capacity and pH/thermo-responsive drug release in one entity. The prepared PDPP3T@PSNiAA NPs exhibited high photothermal conversion e?ciency (η=34.1%) and excellent photoacoustic (PA) brightness. Meanwhile, benefiting from the photothermal effect of PDPP3T and the pH/thermal-responsive properties of PSNiAA, Dox-loaded PDPP3T@PSNiAA NPs (PDPP3T@PSNiAA-Dox NPs) were able to controllably regulate the release of Dox by pH/NIR light, in which the enhanced drug release at acidic condition upon NIR irradiation phenomenon would minimize unnecessary drug release in normal tissues and was highly beneficial for precise synergistic chemo- and photothermal therapy.
关键词： Photoacoustic image,Doxorubicin,Drug release,Chemo-photothermal therapy,pH/NIR-responsive,Semiconducting polymer
更新于2025-09-10 09:29:36