研究目的
To develop a theranostic system based on semiconducting polymer nanoparticles (L1057 NPs) for NIR-II fluorescence imaging and photothermal therapy (PTT) under safe laser fluence, addressing the challenge of insufficient effective NIR-II brightness and excellent photothermal properties in current systems.
研究成果
The study concludes that L1057 NPs are an excellent theranostic system for NIR-II imaging and PTT under safe laser fluence, with high effective NIR-II brightness, good stability, and excellent biocompatibility. The findings suggest that L1057 NPs have great potential for a wide range of biomedical applications.
研究不足
The study acknowledges the challenge of developing biocompatible NIR-II contrast agents with sufficient effective NIR-II brightness for imaging and high photothermal properties for PTT under safe laser fluence. The limitations include the need for further optimization of the L1057 NPs for clinical applications.
1：Experimental Design and Method Selection:
The study involved the synthesis of a semiconducting polymer (PTQ) and its encapsulation into nanoparticles (L1057 NPs) for biomedical applications.
2：Sample Selection and Data Sources:
The study utilized L1057 NPs for in vitro and in vivo experiments, including whole-body imaging, brain angiography, and tumor detection.
3：List of Experimental Equipment and Materials:
Equipment included a Bruker Avance III 400 MHz NMR spectrometer, JEOL JEM-2100 electron microscope, Shimadzu UV-1750 spectrometer, and Edinburgh instruments FLS
4：Materials included PTQ, DSPE-PEG2000, and IR26 dye. Experimental Procedures and Operational Workflow:
9 The study involved the synthesis of PTQ, preparation of L1057 NPs, characterization of their optical properties, and evaluation of their performance in NIR-II imaging and PTT.
5：Data Analysis Methods:
The study employed fluorescence imaging, photothermal imaging, and statistical analysis to evaluate the performance of L1057 NPs.
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