研究目的
To examine the outcome of transfoveal subthreshold micropulse laser treatment (SMPLT) of central serous chorioretinopathy (CSCR) performed at six months or less after disease onset.
研究成果
Patients with acute CSCR may benefit from early treatment with SMPLT. The application of this therapy within the first weeks of the disease promoted better functional improvement in comparison to later treatment.
研究不足
The study is based on a relatively small sample. Further studies involving larger groups of patients are needed, especially involving the evaluation of retinal function beyond BCVA (microperimetry or multi-focal electroretinography). The study presents a case series study, not the randomized controlled trial. Longer follow up could also provide information about the recurrence rate after SMPLT.
1：Experimental Design and Method Selection:
The study included 32 cases of CSCR lasting between three weeks and six months. All patients had transfoveal SMPLT applied and were followed for at least three months after each session of SMPLT. Two sessions of SMPLT in total were planned in case of an insufficient response to the first instance of treatment.
2：Sample Selection and Data Sources:
The study included patients with CSCR lasting up to 6 months, presence of active disease defined by the presence of SRF on spectral domain optical coherence tomography (SOCT), subfoveal location of SRF and lack of choroidal neovascularization (CNV).
3：List of Experimental Equipment and Materials:
Zeiss Cirrus 4000; Carl Zeiss AG, Oberkochen, Germany for SOCT examination, Zeiss FF-450; Carl Zeiss AG, Oberkochen, Germany for fluorescein angiography (FA) and fundus autofluorescence (FAF), REVO Copernicus; Optopol Technology, Zawiercie, Poland for OCT angiography, Supra Scan 577; Quantel Medical, Cournon d'Auvergne, France for SMPLT.
4：Experimental Procedures and Operational Workflow:
SMPLT was performed with a 577 nm laser. The procedure was carried out according to the SOCT map, in that the whole SRF area was covered with confluent laser foci of 160 μm in diameter. Fixed laser parameters of 250 mW, a duty cycle at 5%, and a
5：2 s duration were employed in each case. Data Analysis Methods:
Statistical analysis was completed with the use of the Statistica 10.0 software (StatSoft, Tulsa, OK, USA). The normalcy of distribution was assessed using the Shapiro–Wilk test. The significance of the results of treatment was evaluated using the Wilcoxon test. Correlations between the duration of symptoms and the results of treatment were assessed by calculations of Spearman rank coefficients.
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