研究目的
To review the use of near-infrared imaging and optical coherence tomography for intraoperative visualization of tumors, focusing on their mechanisms, systems, contrast agents, and applications in veterinary and human surgery.
研究成果
NIR imaging and OCT offer significant advantages for intraoperative tumor visualization, including real-time results and high spatial resolution. Despite some limitations, these technologies have the potential to improve surgical outcomes by enabling complete tumor resections with clear margins. Future developments in imaging agents and systems are expected to enhance their clinical utility.
研究不足
The depth of light penetration for NIR imaging is limited, and the heterogenous expression of target receptors for targeted fluorophores may affect specificity. OCT's depth of imaging is restricted to 2-3 mm in nontransparent tissues. Both techniques require further clinical trials to establish their widespread applicability.
1：Experimental Design and Method Selection:
The review discusses the mechanisms of near-infrared (NIR) imaging and optical coherence tomography (OCT), including the use of fluorescent contrast agents and light sources for tumor visualization.
2：Sample Selection and Data Sources:
Studies involving human and companion animal tumors are reviewed, with a focus on the applicability of NIR and OCT in surgical oncology.
3：List of Experimental Equipment and Materials:
Includes NIR imaging systems, OCT systems, and various fluorescent contrast agents like Indocyanine green (ICG) and 5-Aminolevulinic acid (ALA).
4：Experimental Procedures and Operational Workflow:
Describes the intraoperative use of NIR and OCT for tumor visualization, margin assessment, and sentinel lymph node mapping.
5：Data Analysis Methods:
Reviews the sensitivity and specificity of NIR and OCT in distinguishing tumor from normal tissue, based on histopathological correlation.
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