研究目的
The purpose of this study was to characterize the prevalence, severity, and duration of anterior chamber inflammation (cells and flare) following selective laser trabeculoplasty (SLT) in Afro-Caribbean eyes with primary open-angle glaucoma (POAG).
研究成果
SLT in Afro-Caribbean people with POAG is associated with mild, short-lived and self-limited anterior chamber inflammation. Routine anti-inflammatory therapy to suppress posttreatment inflammation after SLT is unnecessary in this population.
研究不足
The schedule of visits precludes more precise characterization of the time course to onset and resolution of anterior segment inflammation in these eyes. Also, the study was not powered specifically for this analysis.
1：Experimental Design and Method Selection:
A prospective evaluation of the efficacy and safety of monotherapy SLT in an Afro-Caribbean sample of subjects on the islands of Saint Lucia and Dominica.
2：Sample Selection and Data Sources:
A convenience sample of adult subjects with early or moderate open-angle glaucoma by ISGEO criteria was recruited from existing practices in Saint Lucia and Dominica.
3：List of Experimental Equipment and Materials:
Lumenis Selecta II portable slit-lamp mounted laser system.
4：Experimental Procedures and Operational Workflow:
Subjects underwent first-time 360-degree SLT treatment following washout of all topical medications. No anti-inflammatory therapy was used post-SLT. Anterior chamber cells and flare were characterized pre-SLT after medication washout, and 1 week, 6 weeks, and 3, 6, 9 and 12 months post-SLT using the standardized methodology described by the Society for Uveitis Nomenclature (SUN).
5：Data Analysis Methods:
Mean cell and flare values at baseline and each visit through 12 months after initial SLT were determined and changes in cell and flare from baseline were evaluated separately in right and left eyes using paired t tests.
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