研究目的
To differentiate the microvascular function between subjects with cardiometabolic disorders and healthy controls.
研究成果
A novel approach to characterize LDF during PORH was useful to better differentiate between microvascular responses associated with cardiometabolic disorders from healthy subjects. The improvement in the assessment of microvascular dysfunction is needed for both clinical and research purposes.
研究不足
The lack of consensus concerning the parameter selection, along with some methodological issues resulting in high intrasubject variability, have limited the application of LDF coupled to PORH for both clinical and research purposes.
1：Experimental Design and Method Selection:
A cross-sectional study was carried out including data from twenty subjects with history of cardiometabolic disorders (CMD) and twenty healthy controls. LDF was used during post-occlusive reactive hyperemia (PORH) to assess microvascular function.
2：Sample Selection and Data Sources:
Subjects were between 40 and 60 years old, with or without history of CMD. Controls were free from CMD and not smokers.
3：List of Experimental Equipment and Materials:
LDF probe (DRT4, Moor Instruments Ltd), pneumatic cuff, moorVMS-HEAT Skin Heater Unit (Moor Instruments Ltd), software MoorSoft for Windows/DRT4 v
4：2 (Moor Instruments Ltd). Experimental Procedures and Operational Workflow:
Participants were placed in supine position. Baseline microvascular flow was recorded for 3 minutes, followed by arterial occlusion for 3 minutes, and then PORH was recorded over 3 minutes.
5：Data Analysis Methods:
Microvascular reactivity was assessed by referring the Peak Flow (PF) to its Baseline Flow (BF), as the Reactive Hyperemia Flow Index (RHFIx). Additional parameters were calculated to characterize the response.
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