研究目的
Investigating the performance of the surface-enhanced Raman spectroscopy (SERS) substrate based on high-density gold nanostar nanoparticle (GNS) arrays assembled on the gold film and embedded in the human skin tissue as a surrounding medium.
研究成果
The high-density GNSs arrays on the Au film are characterized by a high SERS EF dependent on the interactions of the GNS–Au film, GNS–GNS in the gap regions, and the GNSs at their branches. The proposed SERS substrates possess great potential in intracellular imaging, medical diagnostics, and therapy.
研究不足
The synthesis of GNSs is difficult and for some cases impractical. The study relies on simulation, and practical implementation may face challenges in synthesizing the thinner Au film and controlling the NPs aggregation.
1：Experimental Design and Method Selection:
The study employs a finite difference time domain (FDTD) calculation for the analysis of the optical properties of the structures.
2：Sample Selection and Data Sources:
GNS arrays assembled on the Au film and embedded in the human skin tissue are simulated.
3：List of Experimental Equipment and Materials:
Gold nanostar nanoparticles (GNSs), Au film, 3-aminopropyltriethoxy silane (APTES), and human skin tissue.
4：Experimental Procedures and Operational Workflow:
The GNS arrays are excited by a linearly polarized plane wave of 785-nm wavelength. The interaction between the GNS array and nanostar branches creates a strong local field enhancement in the hot spot inside the gap.
5：Data Analysis Methods:
The SERS enhancement factors (EFs) are calculated based on the electric field distribution.
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