研究目的
Investigating the photothermal conversion efficiency of plasmonic nanoparticles in aqueous dispersions using terahertz radiation for potential applications in nanomedicine and photothermal therapy.
研究成果
The study demonstrated a novel, noncontact, and noninvasive method for quantifying the photothermal conversion efficiency of plasmonic nanoparticles using terahertz radiation. The technique provides accurate measurements of temperature transients and spatial distributions, offering an alternative to conventional invasive methods. The findings have significant implications for the optimization of photothermal therapies in nanomedicine.
研究不足
The method requires nanomaterials that exhibit a temperature-dependent variation of the refractive index in the terahertz regime. The spatial resolution of thermal imaging is limited by the terahertz focusing spot size. The technique may not be suitable for samples with high terahertz absorption.
1：Experimental Design and Method Selection:
The study employed terahertz time-domain spectroscopy (THz-TDS) in reflection geometry to measure the photothermal effect of gold nanorod (GNR) dispersions. The method combines spatial and temporal thermal dynamics to quantify the photothermal conversion efficiency.
2：Sample Selection and Data Sources:
Three types of commercially available water-based gold nanorod (GNR) dispersions with particle diameters of 10 nm, 25 nm, and 50 nm were used. The samples were characterized using UV/VIS/NIR spectroscopy.
3：List of Experimental Equipment and Materials:
The setup included a THz-TDS system based on photoconductive antennas (PCAs), a laser source for NIR illumination, a standard polyethylene (PE) cuvette, and a motorized translation stage for raster-scans.
4：Experimental Procedures and Operational Workflow:
The GNR dispersions were illuminated with a NIR laser to induce plasmonic heating. The temperature changes were monitored using THz-TDS in reflection geometry. Thermal imaging was performed to map the temperature distribution.
5：Data Analysis Methods:
The temperature transients and thermal images were analyzed to extract the photothermal conversion efficiency and molar heating rate (MHR). Theoretical modeling was used to predict the photothermal response based on the nanoparticles' geometry.
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