研究目的
To design and prepare a hollow mesoporous silica drug transport system based on fluorescent carbon quantum dot filling for efficient drug loading and imaging.
研究成果
The prepared drug transport system has a particle size of about 90 nm with a large cavity volume, ensuring efficient drug loading. The system exhibits good fluorescence for imaging and can release drugs effectively under acidic conditions, making it a promising candidate for drug delivery and imaging applications.
研究不足
The study did not explore the potential photothermal effects of carbon quantum dots for controlled drug release in detail. Future research could focus on this aspect.
1：Experimental Design and Method Selection:
The study involved the preparation of hollow mesoporous silica nanospheres (HMSN) filled with carbon quantum dots (CDs) for drug delivery and imaging. The methodology included selective etching for HMSN preparation and hydrothermal method for CDs filling.
2：Sample Selection and Data Sources:
Solid silica nanospheres were prepared as cores, and CTAB was used as a pore-forming agent for mesoporous silica coating.
3：List of Experimental Equipment and Materials:
TEOS, CTAB, sodium carbonate, citric acid, ethylenediamine, and other chemicals were used. Equipment included an oil bath, magnetic stirrer, and high-pressure reactor.
4：Experimental Procedures and Operational Workflow:
The process involved preparation of nSiO2, nSiO2@mSiO2, selective etching, filling with CDs, and surface modification.
5：Data Analysis Methods:
Fluorescence properties, BET surface area, and drug release capacity were analyzed.
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